Results 221 to 230 of about 115,123 (247)

MG53 Coordinates Macrophage Polarization and Neuroimmune Coupling to Promote Corneal Nerve Regeneration via the MPEG1–MVP–STAT6 Axis

Advanced Science, EarlyView.
Corneal nerve regeneration is critical to corneal wound healing processes. The current study reveals a novel role of MG53 in promoting corneal nerve regeneration after alkali induced injury. Mechanistically, MG53 enters macrophages via its receptor, MPEG1, promotes MVP K63 ubiquitination, and triggers STAT6 induced repair‐related genes expression ...
Peng Chen, Zhentao Zhang, Lilian Sakai, Yanping Xu, Luxi Zhang, Han Ye, William Sollenberger, Takahide Ikeda, Zhiyu Yan, Keerthika Sathish, Usman Alizai, Haitao Wen, Timothy M. Pawlik, Heather L. Chandler, Hua Zhu   +14 more
wiley   +1 more source

The Genetic Diversity and Drug Resistance Patterns of HIV-1 Pol Gene in East Africa. [PDF]

Adv Virol
Kavuraya AN, Mselle T, Mpenda FN.
europepmc   +1 more source

A Nanobody‐LNP Platform for Targeting and Relicensing Dendritic Cells for Potent Cancer Immunotherapy

Advanced Science, EarlyView.
Plastin‐2 (PLS2) is identified as a dual‐function receptor on DCs that mediates both nanoparticle uptake and immunomodulation. A nanobody‐LNP platform is engineered to integrate antigen delivery with relicensing DCs. The therapeutic strategy elicits potent anti‐tumor T cell responses and leads to significant inhibition of established tumors in vivo ...
Shugang Qin, Zhiying Huang, Hai Huang, Yupei Zhang, Yuting Chen, Xi He, Zhenyi Niu, Zhongzheng Xiang, Chaoyu Zou, Xiangrong Song   +9 more
wiley   +1 more source

An Assessment of Regional Genetic Diversity of HIV-1. [PDF]

Viruses
Antonova A, Kuznetsova AV, Kuznetsova AI, Mazus A, Loifman E, Grigoreva L, Kleimenov D, Bykonia E, Shcheblyakov D, Favorskaya I, Pochtovyi A, Tsyganova E, Kulikova I, Plutnitskii A, Gushchin V, Gintsburg A.   +15 more
europepmc   +1 more source

A Rational Optimization Approach for the Development of a Multiplexed Lateral Flow Immunoassay: Detection of Nonepithelial Ovarian Cancer Markers in Human Serum

Advanced Science, EarlyView.
This study outlines the developmental pipeline of a multiplexed nanozyme‐based lateral flow immunoassay for the purpose of ovarian germ cell tumor detection. It demonstrates the application of a design of experiments optimization approach for nanozyme probe conjugate development.
Aida Abdelwahed, Carl E. Eskildsen, Luca Panariello, André Shamsabadi, Christy J. Sadler, Edmund H. Wilkes, Federico Galvanin, Yuxi Cheng, Sara Carvalho, Srdjan Saso, Molly M. Stevens   +10 more
wiley   +1 more source

Extracellular vesicles carrying surface-anchored adiponectin prevent obesity-related metabolic complications by enhancing insulin sensitivity. [PDF]

Mol Metab
Blandin A, Voisin M, Froger J, Lachat M, Hilairet G, Polak K, Magusto J, Meslier L, Croyal M, Gourdel M, Massiquot Q, Chaigneau J, Carpentier M, Fizanne L, Prieur X, Le May C, Boursier J, Cariou B, Mamoun R, Trentin B, Le Lay S.   +20 more
europepmc   +1 more source

Efficacy of dolutegravir-based therapy in achieving virological suppression in PLHIV in low- and middle-income countries: real-world evidence from a large clinical cohort in Cameroon. [PDF]

BMC Infect Dis
Tadenfok C, Fokam J, Semengue ENJ, Mossiang L, Oyie S, Noumo P, Ngia J, Beloumou GA, Djupsa Ndjeyep SC, Nka AD, Chenwi Ambe C, Ka'e AC, Takou D, Ngwese DTA, Anim-Keng TT, Forgwei L, Kengne A, Yagai B, Elong Lobe E, Feukeng A, Awoh RA, Bissek AZ, Vouking M, Ndjolo A, Ndembi N, Perno CF, Kouanfack C, Nkenfou C.   +27 more
europepmc   +1 more source

Hemophilia and hereditary angioedema: parallel therapeutic advances in genetic diseases of serine protease pathways. [PDF]

Res Pract Thromb Haemost
Cugno M, Mannucci PM.
europepmc   +1 more source

Angiopoietin-like 3 monomers are abundant in human plasma but are unable to inhibit endothelial lipase. [PDF]

JCI Insight
Walker SG, Chen YQ, Sylvers-Davie KL, Dou A, Zhen EY, Qian Y, Wen Y, Ehsani M, Smith S, Thapa R, Mercer MJ, Langmack L, Bhattarai BR, Ploug M, Konrad RJ, Davies BS.   +15 more
europepmc   +1 more source