Results 151 to 160 of about 1,992,684 (401)

Cell-free circulating tumor DNA in cancer

Chinese Journal of Cancer, 2016
Cancer is a common cause of death worldwide. Despite significant advances in cancer treatments, the morbidity and mortality are still enormous. Tumor heterogeneity, especially intratumoral heterogeneity, is a significant reason underlying difficulties in
Zhen Qin, Vladimir A. Ljubimov, Cuiqi Zhou, Yunguang Tong, Jimin Liang   +4 more
doaj   +1 more source

Circulating Tumor Cells in Melanoma Patients

PLoS ONE, 2012
Circulating tumor cells (CTCs) are of recognized importance for diagnosis and prognosis of cancer patients. With melanoma, most studies do not show any clear relationship between CTC levels and stage of disease. Here, CTCs were enriched (∼400X) from blood of melanoma patients using a simple centrifugation device (OncoQuick), and 4 melanocyte target ...
Rogerio I. Neves, Eric T. Kimchi, Susan D. Patrick, Ping Xin, Kevin F. Staveley-O'Carroll, Ramdane Harouaka, Gary A. Clawson, Siyang Zheng, Diane Thiboutot, Todd D. Schell, Arthur Berg, Paul J. Mosca   +11 more
openaire   +5 more sources

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Better together: circulating tumor cell clustering in metastatic cancer

Trends in Cancer, 2021
Emma J Schuster, Rokana Taftaf, C. Reduzzi, Mary K Albert, I. Romero-Calvo, Huiping Liu   +5 more
semanticscholar   +1 more source

Analytical and Clinical Validation of a Digital Sequencing Panel for Quantitative, Highly Accurate Evaluation of Cell-Free Circulating Tumor DNA

PLoS ONE, 2015
Next-generation sequencing of cell-free circulating solid tumor DNA addresses two challenges in contemporary cancer care. First this method of massively parallel and deep sequencing enables assessment of a comprehensive panel of genomic targets from a ...
R. Lanman, S. Mortimer, Oliver A. Zill, Dragan Sebisanovic, Rene Lopez, S. Blau, E. Collisson, S. Divers, D. Hoon, E. Kopetz, Jeeyun Lee, P. Nikolinakos, A. Baca, B. Kermani, H. Eltoukhy, Amirali Talasaz   +15 more
semanticscholar   +1 more source

Entry effects of droplet in a micro confinement: implications for deformation-based CTC microfiltration

, 2015
Deformation based circulating tumor cell (CTC) microchips are a representative diagnostic device for early cancer detection. This type of device usually involves a process of CTC trapping in a confined microgeometry. Further understanding of the CTC flow
Chen, Xiaolin, Xu, Jie, Zhang, Zhifeng
core   +1 more source

Activated lymphocyte recruitment into the tumor microenvironment following preoperative sipuleucel-T for localized prostate cancer. [PDF]

, 2014
BackgroundSipuleucel-T is a US Food and Drug Administration-approved immunotherapy for asymptomatic or minimally symptomatic metastatic castration-resistant prostate cancer (mCRPC). Its mechanism of action is not fully understood.
Amling, Christopher L, Carroll, Peter, Chan, Stephen, Corman, John, Fong, Lawrence, Frohlich, Mark W, Lewis, Jera, Sheikh, Nadeem A, Simko, Jeffrey, Sims, Robert B, Small, Eric J, Stephenson, Robert A, Weinberg, Vivian   +12 more
core   +2 more sources

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Efficient presentation of tumor idiotype to autologous T cells by CD83+ dendritic cells derived from highly purified circulating CD14+ monocytes in multiple myeloma patients [PDF]

, 2000
Marina Ratta, Antonio Curti, Miriam Fogli, Mirko Pantucci, G.C. Viscomi, Pier Luigi Tazzari, Francesco Fagnoni, Rosanna Vescovini, Paolo Sansoni, S Tura, Roberto M. Lemoli   +10 more
openalex   +1 more source

Functional profiling of circulating tumor cells with an integrated vortex capture and single-cell protease activity assay

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance The current paradigm in liquid biopsies focuses on circulating tumor cell (CTC) count and genomics to provide clinically actionable information.
Manjima Dhar, Jeffrey Nam Lam, Tonya C. Walser, S. Dubinett, M. Rettig, D. Di Carlo   +5 more
semanticscholar   +1 more source