Circulating Cell-Free DNA in Dogs with Mammary Tumors: Short and Long Fragments and Integrity Index. [PDF]
PLoS ONE, 2017 Circulating cell-free DNA (cfDNA) has been considered an interesting diagnostic/prognostic plasma biomarker in tumor-bearing subjects. In cancer patients, cfDNA can hypothetically derive from tumor necrosis/apoptosis, lysed circulating cells, and some ...
Giorgia Beffagna +14 more
doaj +13 more sources
Label-free enrichment of rare unconventional circulating neoplastic cells using a microfluidic dielectrophoretic sorting device [PDF]
Communications Biology, 2021 Montoya Mira & Sapre et al. design a microfluidic device utilizing dielectrophoresis for the enrichment of circulating neoplastic cells that possess both epithelial and immune-like characteristics. They optimized the device using in vitro models and then
Jose Montoya Mira +9 more
doaj +4 more sources
Detection of circulating hybrid cells and circulating tumor cells in cerebrospinal fluid for leptomeningeal metastasis diagnosis and therapeutic prediction [PDF]
Frontiers in Cell and Developmental BiologyPurposeLeptomeningeal metastasis (LM) represents a serious complication of advanced malignancies with poor prognosis. Conventional diagnostic approaches, such as MRI and cerebrospinal fluid (CSF) cytology lack sufficient sensitivity—particularly in early-
Yanting Liu +16 more
doaj +2 more sources
B-cell chronic lymphocytic leukaemia in an African lion (Panthera leo) [PDF]
Veterinární Medicína, 2018 A 15-year-old female African lion (Panthera leo) maintained at the Zoological Garden of Pistoia, Tuscany (Italy), showed signs of malaise, dyspnoea, tremors, pale mucous membranes and ataxia for two days prior to death.
R. Meoli +6 more
doaj +3 more sources
Heterogeneity of Circulating Tumor Cell Neoplastic Subpopulations Outlined by Single-Cell Transcriptomics [PDF]
Cancers, 2021 Fatal metastasis occurs when circulating tumor cells (CTCs) disperse through the blood to initiate a new tumor at specific sites distant from the primary tumor. CTCs have been classically defined as nucleated cells positive for epithelial cell adhesion molecule and select cytokeratins (EpCAM/CK/DAPI), while negative for the common lymphocyte marker ...
Christine M. Pauken +5 more
openaire +3 more sources
Current Status and Prospects of Liquid Biopsy for Hepatocellular Carcinoma
The Korean Journal of Gastroenterology, 2023 Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths globally. Early detection and treatment response monitoring of HCC are vital for improved outcomes.
Jumi Kang, Soon Sun Kim
doaj +1 more source
In vitro assessment of antiproliferative action selectivity of dietary isothiocyanates for tumor versus normal human cells [PDF]
Vojnosanitetski Pregled, 2016 Background/Aim. Numerous epidemiological studies have shown beneficial effects of cruciferous vegetables consumption in cancer chemoprevention.
Konić-Ristić Aleksandra +6 more
doaj +1 more source
Circulating hypergranular neoplastic cells: not always leukemic promyelocytes [PDF]
Blood, 2017 ![Figure][1] A 39-year-old woman presented with severe low back pain, hepatosplenomegaly, leukocytosis (15.9 × 109/L), anemia (7.3 g/dL), thrombocytopenia (48 × 109/L), and elevated serum tryptase (>200 ng/mL). Coagulation was normal.
Concepción Prats-Martín +1 more
openaire +3 more sources
Frontiers in Veterinary Science, 2021 Epithelial cell adhesion molecule (EpCAM) is a transmembrane protein expressed at intercellular junctions in epithelial cells. As an epithelial biomarker, it used for immunologic-based capture of epithelial-derived circulating tumor cells (CTCs) in human
Christa Y. Heyward +4 more
doaj +1 more source
Relevance of circulating hybrid cells as a non-invasive biomarker for myriad solid tumors
Scientific Reports, 2021 Metastatic progression defines the final stages of tumor evolution and underlies the majority of cancer-related deaths. The heterogeneity in disseminated tumor cell populations capable of seeding and growing in distant organ sites contributes to the ...
Matthew S. Dietz +33 more
doaj +1 more source