Results 1 to 10 of about 217,168 (254)

Label-free enrichment of rare unconventional circulating neoplastic cells using a microfluidic dielectrophoretic sorting device [PDF]

Communications Biology, 2021
Montoya Mira & Sapre et al. design a microfluidic device utilizing dielectrophoresis for the enrichment of circulating neoplastic cells that possess both epithelial and immune-like characteristics. They optimized the device using in vitro models and then
Jose Montoya Mira, Ajay A. Sapre, Brett S. Walker, Jesus Bueno Alvarez, Kyle T. Gustafson, Eugene Tu, Jared M. Fischer, Melissa H. Wong, Sadik Esener, Yu-Jui Chiu   +9 more
doaj   +4 more sources

Circulating extracellular vesicle-microRNAs (EV-miRNAs) in leukemias and related disorders [PDF]

Frontiers in Medicine
Extracellular vesicles (EVs) are nanoparticles released from all cell types and function as a biological tool for cell-to-cell communication or organs located even in remote parts.
Tsukuru Umemura, Tsukuru Umemura, Tatsuki Shibuta, Yukichi Takada   +3 more
doaj   +2 more sources

Circulating hypergranular neoplastic cells: not always leukemic promyelocytes [PDF]

Blood, 2017
![Figure][1] A 39-year-old woman presented with severe low back pain, hepatosplenomegaly, leukocytosis (15.9 × 109/L), anemia (7.3 g/dL), thrombocytopenia (48 × 109/L), and elevated serum tryptase (>200 ng/mL). Coagulation was normal.
Rosario Mª Morales Camacho, Concepción Prats-Martín   +1 more
exaly   +4 more sources

Circulating Neoplastic-Immune Hybrid Cells Predict Metastatic Progression in Uveal Melanoma

Cancers, 2022
Background: Uveal melanoma is an aggressive cancer with high metastatic risk. Recently, we identified a circulating cancer cell population that co-expresses neoplastic and leukocyte antigens, termed circulating hybrid cells (CHCs). In other cancers, CHCs are more numerous and better predict oncologic outcomes compared to circulating tumor cells (CTCs).
Yuki Chin, Young Hwan Chang, Thomas L Sutton   +2 more
exaly   +3 more sources

Detection of circulating hybrid cells and circulating tumor cells in cerebrospinal fluid for leptomeningeal metastasis diagnosis and therapeutic prediction [PDF]

Frontiers in Cell and Developmental Biology
PurposeLeptomeningeal metastasis (LM) represents a serious complication of advanced malignancies with poor prognosis. Conventional diagnostic approaches, such as MRI and cerebrospinal fluid (CSF) cytology lack sufficient sensitivity—particularly in early-
Yanting Liu, Jiaxin Liang, Min Zhang, Nianhua Cao, Jie Xue, Xiaodi Zhang, YongXu Jia, Zhiwei Chang, Guodong Zhang, Yan Li, Hongyan Hui, Ruijuan Fan, Kelei Zhao, Zongbin Liu, Guifang Zhang, Ping Lu, Yinghua Ji   +16 more
doaj   +2 more sources

Circulating angiogenic cells in glioblastoma: toward defining crucial functional differences in CAC-induced neoplastic versus reactive neovascularization [PDF]

Neuro-Oncology Advances, 2020
AbstractBackgroundIn order to identify suitable therapeutic targets for glioma anti-angiogenic therapy, the process of neovascularization mediated by circulating angiogenic cells (CACs) needs to be scrutinized.MethodsIn the present study, we compared the expression of neovascularization-related genes by 3 circulating CAC subsets (hematopoietic ...
Peter J Van Der Spek, Johan Kros, Dana Mustafa   +2 more
exaly   +5 more sources

Neoplastic circulating endothelial cells in multiple myeloma with 13q14 deletion

Blood, 2006
Abstract In multiple myeloma (MM), circulating endothelial cells (CECs) represent a vascular marker of angiogenesis and may reflect tumor mass. In this report, we showed that, in 5 MM patients with 13q14 deletion, CECs carried the same chromosome aberration as the neoplastic plasma cells (11%-32% of CECs with 13q14 deletion). Most of the
Massimo Negrini, Gian Matteo Rigolin, Mauro Endri   +2 more
exaly   +5 more sources

Flow cytometry in the detection of circulating tumor cells in neoplastic effusions

Clinica Chimica Acta
Despite its limitations, the cytology of body fluids is widely used in diagnosing neoplastic cells. Flow cytometry detects and identifies individual cells, enabling the detection of circulating tumor cells and facilitating diagnosis. This study compared the diagnostic utility of flow cytometry and cytology for detecting cancer cells in peritoneal and ...
Magdalena Bodnar, Karol Gostomczyk
exaly   +3 more sources

Exploratory Analyses of Circulating Neoplastic-Immune Hybrid Cells as Prognostic Biomarkers in Advanced Intrahepatic Cholangiocarcinoma

International Journal of Molecular Sciences
Existing clinical biomarkers do not reliably predict treatment response or disease progression in patients with advanced intrahepatic cholangiocarcinoma (ICC). Circulating neoplastic-immune hybrid cells (CHCs) have great promise as a blood-based biomarker for patients with advanced ICC.
Brett Walker, Young Hwan Chang, Charles Lopez   +2 more
exaly   +3 more sources

Circulating Neoplastic-Immune Hybrid Cells Are Biomarkers of Occult Metastasis and Treatment Response in Pancreatic Cancer

Cancers
Background/Objectives: Pancreatic ductal adenocarcinoma (PDAC) presents significant diagnostic and prognostic challenges, as current biomarkers frequently fail to accurately stage disease, predict rapid metastatic recurrence (rPDAC), or assess response to neoadjuvant therapy (NAT).
Summer Gibbs, Young Hwan Chang, Charles Lopez   +2 more
exaly   +3 more sources