Results 21 to 30 of about 508,130 (309)

Neoplastic circulating endothelial-like cells in patients with acute myeloid leukaemia

European Journal of Haematology, 2007
Accumulating evidence suggests that angiogenesis may play a key role in the pathogenesis of leukaemic disorders. Several studies have shown that bone marrow-derived endothelial cells (EC) may contribute to tumour angiogenesis and that in the peripheral ...
FRAULINI, Chiara, CUNEO, Antonio, MAURO, Endri, RIGOLIN, Gian Matteo, SOFRITTI, Olga, CICCONE, Maria, CASTOLDI, Gianluigi   +6 more
core   +4 more sources

Circulating Neoplastic-Immune Hybrid Cells Are Biomarkers of Occult Metastasis and Treatment Response in Pancreatic Cancer

Cancers
Background/Objectives: Pancreatic ductal adenocarcinoma (PDAC) presents significant diagnostic and prognostic challenges, as current biomarkers frequently fail to accurately stage disease, predict rapid metastatic recurrence (rPDAC), or assess response ...
Ranish K Patel, Michael S Parappilly, Byung S Park   +2 more
exaly   +4 more sources

Relevance of circulating hybrid cells as a non-invasive biomarker for myriad solid tumors

Scientific Reports, 2021
Metastatic progression defines the final stages of tumor evolution and underlies the majority of cancer-related deaths. The heterogeneity in disseminated tumor cell populations capable of seeding and growing in distant organ sites contributes to the ...
Matthew S. Dietz, Thomas L. Sutton, Brett S. Walker, Charles E. Gast, Luai Zarour, Sidharth K. Sengupta, John R. Swain, Jennifer Eng, Michael Parappilly, Kristen Limbach, Ariana Sattler, Erik Burlingame, Yuki Chin, Austin Gower, Jose L. Montoya Mira, Ajay Sapre, Yu-Jui Chiu, Daniel R. Clayburgh, SuEllen J. Pommier, Jeremy P. Cetnar, Jared M. Fischer, Jerry J. Jaboin, Rodney F. Pommier, Brett C. Sheppard, V. Liana Tsikitis, Alison H. Skalet, Skye C. Mayo, Charles D. Lopez, Joe W. Gray, Gordon B. Mills, Zahi Mitri, Young Hwan Chang, Koei Chin, Melissa H. Wong   +33 more
doaj   +2 more sources

Circulating senescent myeloid cells infiltrate the brain and cause neurodegeneration in histiocytic disorders

Immunity, 2023
Neurodegenerative diseases (ND) are characterized by progressive loss of neuronal function. Mechanisms of ND pathogenesis are incompletely understood, hampering the development of effective therapies.
McClain, Kenneth L; https://orcid.org/, Silvin, Aymeric, Manz, Markus G; https://orcid.org/, Cathomas, Flurin; https://orcid.org/, Aubry, Antonio, Picarsic, Jennifer L; https://orcid.org/, Park, Matthew D, Allen, Carl E; https://orcid.org/, Bigenwald, Camille; https://orcid.org/, Scull, Brooks P, Dangoor, Diana, Hamon, Pauline; https://orcid.org/, Crary, John F, Wilk, C Matthias; https://orcid.org/, Merad Taouli, Elias, Kofler, Julia K, Ginhoux, Florent; https://orcid.org/, Le Berichel, Jessica, Yue, Zhenyu; https://orcid.org/, Li, Long, Lira, Sergio A, Troncoso, Leanna; https://orcid.org/, Török, Orsolya; https://orcid.org/, Merad, Miriam; https://orcid.org/, Heaton, George R, Fleischmann, Ryan, Russo, Scott J, Boettcher, Steffen; https://orcid.org/, Lin, Howard; https://orcid.org/, Belabed, Meriem; https://orcid.org/   +29 more
core   +3 more sources

Circulating extracellular vesicle-microRNAs (EV-miRNAs) in leukemias and related disorders [PDF]

Frontiers in Medicine
Extracellular vesicles (EVs) are nanoparticles released from all cell types and function as a biological tool for cell-to-cell communication or organs located even in remote parts.
Tsukuru Umemura, Tsukuru Umemura, Tatsuki Shibuta, Yukichi Takada   +3 more
doaj   +2 more sources

Circulating hypergranular neoplastic cells: not always leukemic promyelocytes [PDF]

Blood, 2017
![Figure][1] A 39-year-old woman presented with severe low back pain, hepatosplenomegaly, leukocytosis (15.9 × 109/L), anemia (7.3 g/dL), thrombocytopenia (48 × 109/L), and elevated serum tryptase (>200 ng/mL). Coagulation was normal.
Concepción Prats-Martín, Rosario M Morales-Camacho, Prats-Martín Concepción   +2 more
exaly   +4 more sources

Comprehensive Atlas of Circulating Rare Cells Detected by SE-iFISH and Image Scanning Platform in Patients With Various Diseases

Frontiers in Oncology, 2022
ObjectiveCirculating rare cells (CRCs) are known as a crucial nucleated cellular response to pathological conditions, yet the landscape of cell types across a wide variety of diseases lacks comprehensive understanding.
Binjie Hu, Yanping Gong, Yulan Wang, Jianzhu Xie, Jin Cheng, Qian Huang   +5 more
doaj   +2 more sources

Pivotal Role of Pervasive Neoplastic and Stromal Cells Reprogramming in Circulating Tumor Cells Dissemination and Metastatic Colonization [PDF]

Cancer Microenvironment, 2014
Reciprocal interactions between neoplastic cells and their microenvironment are crucial events in carcinogenesis and tumor progression. Pervasive stromal reprogramming and remodeling that transform a normal to a tumorigenic microenvironment modify numerous stromal cells functions, status redox, oxidative stress, pH, ECM stiffness and energy metabolism.
Didier, Meseure, Kinan, Drak Alsibai, Andre, Nicolas   +2 more
openaire   +3 more sources

Prognostic Value of Multiple Reverse Transcription-PCR Tyrosinase Testing for Circulating Neoplastic Cells in Malignant Melanoma [PDF]

Clinical Chemistry, 2003
Abstract Background: The reverse transcription-PCR tyrosinase assay (TYR test) cannot reliably detect malignant melanoma (MM) cells in blood as the cells often circulate at low concentrations. We evaluated the prognostic value of multiple TYR testing, the prognostic significance of individual positive TYR test results (TYR+) in ...
Szenajch, Jolanta, Jasiński, Bogdan, Synowiec, Agnieszka, Kulik, Jadwiga, Chomicka, Małgorzata, Strużyna, Jerzy, Nowecki, Zbigniew, Rutkowski, Piotr, Ruka, Włodzimierz, Kupść, Witold, Siedlecki, Janusz, Wiesław Wiktor Jędrzejczak   +11 more
openaire   +3 more sources

Circulating tumor DNA – from biology to potential clinical applications in diffuse large B-cell lymphomas

Contemporary Oncology
During the last 20 years, significant progress has been made in understanding the biology of cancer cells. Assessment of the molecular profile of neoplastic cells collected by tissue biopsy using next-generation sequencing techniques makes it possible to
Krzysztof Lewandowski, Kinga Gwóźdź-Bąk   +1 more
doaj   +2 more sources