Results 31 to 40 of about 247,318 (300)

Human plasmacytoid dendritic cells and cutaneous melanoma [PDF]

, 2020
The prognosis of metastatic melanoma (MM) patients has remained poor for a long time. However, the recent introduction of effective target therapies (BRAF and MEK inhibitors for BRAFV600-mutated MM) and immunotherapies (anti-CTLA-4 and anti-PD-1) has ...
Bugatti, Mattia, Consoli, Francesca, Monti, Matilde, Vermi, William, Vescovi, Raffaella   +4 more
core   +2 more sources

Circulating neuregulin-1 and galectin-3 can be prognostic markers in breast cancer [PDF]

, 2017
Background: It is important to identify novel plasmatic biomarkers that can contribute to assessing the prognosis and outcome of breast cancer patients.
Cardelli, Patrizia, DE IULIIS, Francesca, Lanza, Rosina, Salerno, Gerardo, Scarpa, Susanna, Taglieri, Ludovica   +5 more
core   +1 more source

Pivotal Role of Pervasive Neoplastic and Stromal Cells Reprogramming in Circulating Tumor Cells Dissemination and Metastatic Colonization [PDF]

Cancer Microenvironment, 2014
Reciprocal interactions between neoplastic cells and their microenvironment are crucial events in carcinogenesis and tumor progression. Pervasive stromal reprogramming and remodeling that transform a normal to a tumorigenic microenvironment modify numerous stromal cells functions, status redox, oxidative stress, pH, ECM stiffness and energy metabolism.
Didier, Meseure, Kinan, Drak Alsibai, Andre, Nicolas   +2 more
openaire   +2 more sources

Sensitivity of canine hematological cancers to BH3 mimetics

Journal of Veterinary Internal Medicine, 2023
Background Inhibition of antiapoptotic B‐cell lymphoma 2 (BCL2) proteins by small molecule Bcl‐2 homology 3 (BH3) mimetics causes rapid induction of apoptosis of human hematological cancers in vitro and in vivo.
Selvi Jegatheeson, Claire Cannon, Caroline Mansfield, Joanne Devlin, Andrew Roberts   +4 more
doaj   +1 more source

Less micrometastatic risk related to circulating tumor cells after endoscopic breast cancer surgery compared to open surgery

BMC Cancer, 2019
Background Increase of circulating tumor cells (CTCs) has been found after surgery for various carcinomas but not confirmed for breast cancer, and whether endoscopic surgery confers identical effect to CTCs as open surgery did is not clear.
Shichao Li, Wenting Yan, Xinhua Yang, Li Chen, Linjun Fan, Haoxi Liu, Kun Liu, Yi Zhang, Jun Jiang   +8 more
doaj   +1 more source

T-lymphocyte-rich thymoma and myasthenia gravis in a Siberian tiger (Panthera tigris altaica) [PDF]

, 2014
A 10-year-old captive male Siberian tiger (Panthera tigris altaica) presented with acute onset collapse, vomiting and dyspnoea, preceded by a 6-month period of progressive muscle wasting.
A. Routh, Allen, Aronsohn, Blaies, Brandes, C. Lamm, Day, Dewey, Ecco, Hadlow, ISIS, Jacobs, K. Allan, K. Berry, Kang, Kenny, King, Kunzel, Marx, N. Masters, Pye, Ramos-Vara, S. Rivers, Schwartz, Scudamore, Shelton, Shelton, Suster, Travis, Valli, Wallace, Walsh   +31 more
core   +1 more source

From Bench to Bedside in Tongue Muscle Cancer Invasion and Back again: Gross Anatomy, Microanatomy, Surgical Treatments and Basic Research

Life, 2020
Tongue squamous cell carcinoma is the most common malignancy in the oral cavity. Despite advances in diagnosis and treatment, the prognosis of advanced states has not significantly improved.
Luca Calabrese, Maria Eleonora Bizzoca, Roberto Grigolato, Fausto Antonio Maffini, Marta Tagliabue, Rosa Negro, Stefania Leuci, Michele Davide Mignogna, Lorenzo Lo Muzio   +8 more
doaj   +1 more source

KITD816V+ systemic mastocytosis associated with KITD816V+ acute erythroid leukaemia: first case report with molecular evidence for same progenitor cell derivation [PDF]

, 2009
Toll-like receptor (TLR)-9 recognizes CpG motifs in microbial DNA. TLR9 signalling stimulates innate antimicrobial immunity and modulates adaptive immune responses including autoimmunity against chromatin, e.g., in systemic lupus erythematosus (SLE ...
H-P Horny, K K Reichard, K Sotlar, M K Foucar, S A McClintock-Treep   +4 more
core   +1 more source

Immunological backbone of uveal melanoma: is there a rationale for immunotherapy? [PDF]

, 2019
No standard treatment has been established for metastatic uveal melanoma (mUM). Immunotherapy is commonly used for this disease even though UM has not been included in phase III clinical trials with checkpoint inhibitors.
Alessandra Cassano, Apte, Bill, Blom, Brigida Anna Maiorano, De Vries, Durie, Emilio Bria, Ericsson, Ernesto Rossi, Giampaolo Tortora, Gianluigi Petrone, Giovanni Schinzari, Guido Rindi, Ilaria Grazia Zizzari, Lagouros, Makitie, Maria Antonietta Blasi, Maria Grazia Sammarco, Marianna Nuti, Monica Maria Pagliara, Shaw, Sohn, Vincenzo Fiorentino, Whelchel   +24 more
core   +1 more source

Prognostic Value of Multiple Reverse Transcription-PCR Tyrosinase Testing for Circulating Neoplastic Cells in Malignant Melanoma [PDF]

Clinical Chemistry, 2003
Abstract Background: The reverse transcription-PCR tyrosinase assay (TYR test) cannot reliably detect malignant melanoma (MM) cells in blood as the cells often circulate at low concentrations. We evaluated the prognostic value of multiple TYR testing, the prognostic significance of individual positive TYR test results (TYR+) in ...
Jolanta, Szenajch, Bogdan, Jasiński, Agnieszka, Synowiec, Jadwiga, Kulik, Małgorzata, Chomicka, Jerzy, Struzyna, Zbigniew, Nowecki, Piotr, Rutkowski, Włodzimierz, Ruka, Witold, Kupść, Janusz A, Siedlecki, Wiesław, Wiktor-Jedrzejczak   +11 more
openaire   +2 more sources