Results 11 to 20 of about 4,884,808 (294)

Circulating Cells with Macrophage-like Characteristics in Cancer: The Importance of Circulating Neoplastic-Immune Hybrid Cells in Cancer

Cancers, 2022
Cancer remains a significant cause of mortality in developed countries, due in part to difficulties in early detection, understanding disease biology, and assessing treatment response. If effectively harnessed, circulating biomarkers promise to fulfill these needs through non-invasive “liquid” biopsy.
Nicole Giske, Stephen Bowden, Thomas L Sutton   +2 more
exaly   +4 more sources

Circulating Neoplastic-Immune Hybrid Cells Predict Metastatic Progression in Uveal Melanoma

Cancers, 2022
Background: Uveal melanoma is an aggressive cancer with high metastatic risk. Recently, we identified a circulating cancer cell population that co-expresses neoplastic and leukocyte antigens, termed circulating hybrid cells (CHCs). In other cancers, CHCs are more numerous and better predict oncologic outcomes compared to circulating tumor cells (CTCs).
Yuki Chin, Young Hwan Chang, Thomas L Sutton   +2 more
exaly   +4 more sources

Heterogeneity of Circulating Tumor Cell Neoplastic Subpopulations Outlined by Single-Cell Transcriptomics [PDF]

Cancers, 2021
Fatal metastasis occurs when circulating tumor cells (CTCs) disperse through the blood to initiate a new tumor at specific sites distant from the primary tumor. CTCs have been classically defined as nucleated cells positive for epithelial cell adhesion molecule and select cytokeratins (EpCAM/CK/DAPI), while negative for the common lymphocyte marker ...
Yan Guo, Dario Marchetti, Kathryn Brayer   +2 more
exaly   +4 more sources

Label-free enrichment of rare unconventional circulating neoplastic cells using a microfluidic dielectrophoretic sorting device [PDF]

Communications Biology, 2021
Montoya Mira & Sapre et al. design a microfluidic device utilizing dielectrophoresis for the enrichment of circulating neoplastic cells that possess both epithelial and immune-like characteristics. They optimized the device using in vitro models and then
Jose Montoya Mira, Ajay A. Sapre, Brett S. Walker, Jesus Bueno Alvarez, Kyle T. Gustafson, Eugene Tu, Jared M. Fischer, Melissa H. Wong, Sadik Esener, Yu-Jui Chiu   +9 more
doaj   +4 more sources

Neoplastic circulating endothelial cells in multiple myeloma with 13q14 deletion

Blood, 2006
Abstract In multiple myeloma (MM), circulating endothelial cells (CECs) represent a vascular marker of angiogenesis and may reflect tumor mass. In this report, we showed that, in 5 MM patients with 13q14 deletion, CECs carried the same chromosome aberration as the neoplastic plasma cells (11%-32% of CECs with 13q14 deletion). Most of the
RIGOLIN, Gian Matteo, FRAULINI, Chiara, CICCONE, Maria, MAURO, Endri, BUGLI, Anna Maria, DE ANGELI, Cristiano, NEGRINI, Massimo, CUNEO, Antonio, CASTOLDI, Gianluigi   +8 more
openaire   +5 more sources

Skin colonization by circulating neoplastic clones in cutaneous T-cell lymphoma [PDF]

Blood, 2019
Iyer and colleagues used deep sequencing of T-cell receptor genes to demonstrate clonal heterogeneity of mycosis fungoides, with repeated seeding of disparate clones from the blood.
Gane Ka-Shu Wong, Aishwarya Iyer, Dylan Hennessey   +2 more
exaly   +4 more sources

Flow cytometry in the detection of circulating tumor cells in neoplastic effusions

Clinica Chimica Acta
Despite its limitations, the cytology of body fluids is widely used in diagnosing neoplastic cells. Flow cytometry detects and identifies individual cells, enabling the detection of circulating tumor cells and facilitating diagnosis. This study compared the diagnostic utility of flow cytometry and cytology for detecting cancer cells in peritoneal and ...
Jȩdrzej Borowczak, Łukasz Szylberg, Karol Gostomczyk   +2 more
exaly   +3 more sources

Circulating extracellular vesicle-microRNAs (EV-miRNAs) in leukemias and related disorders [PDF]

Frontiers in Medicine
Extracellular vesicles (EVs) are nanoparticles released from all cell types and function as a biological tool for cell-to-cell communication or organs located even in remote parts.
Tsukuru Umemura, Tsukuru Umemura, Tatsuki Shibuta, Yukichi Takada   +3 more
doaj   +2 more sources

Exploratory Analyses of Circulating Neoplastic-Immune Hybrid Cells as Prognostic Biomarkers in Advanced Intrahepatic Cholangiocarcinoma

International Journal of Molecular Sciences
Existing clinical biomarkers do not reliably predict treatment response or disease progression in patients with advanced intrahepatic cholangiocarcinoma (ICC). Circulating neoplastic-immune hybrid cells (CHCs) have great promise as a blood-based biomarker for patients with advanced ICC.
Brett Walker, Young Hwan Chang, Alice Fung   +2 more
exaly   +3 more sources

Current Status and Prospects of Liquid Biopsy for Hepatocellular Carcinoma

The Korean Journal of Gastroenterology, 2023
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths globally. Early detection and treatment response monitoring of HCC are vital for improved outcomes.
Jumi Kang, Soon Sun Kim
doaj   +1 more source