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Tumor heterogeneity and circulating tumor cells
Cancer Letters, 2016In patients with cancer, individualized treatment strategies are generally guided by an analysis of molecular biomarkers. However, genetic instability allows tumor cells to lose monoclonality and acquire genetic heterogeneity, an important characteristic of tumors, during disease progression.
Chufeng Zhang +4 more
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2017
In most solid tumors, it is distant metastases rather than the primary tumor which limit the prognosis. Distant metastases are caused by circulating tumor cells (CTCs) which actively invade the blood stream, attach to the endothelium in the target organ, invade the surrounding parenchyma, and form new tumors.
Sebastián A, García +2 more
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In most solid tumors, it is distant metastases rather than the primary tumor which limit the prognosis. Distant metastases are caused by circulating tumor cells (CTCs) which actively invade the blood stream, attach to the endothelium in the target organ, invade the surrounding parenchyma, and form new tumors.
Sebastián A, García +2 more
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2010
Circulating tumor cells (CTCs) can be separated and characterized from normal hematopoietic cellular constituents by a variety of methods. Different strategies have included separation by physical characteristics, such as size or weight, or by biological characteristics, such as expression of epithelial or cancer-specific markers.
Daniel F, Hayes, Jeffrey B, Smerage
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Circulating tumor cells (CTCs) can be separated and characterized from normal hematopoietic cellular constituents by a variety of methods. Different strategies have included separation by physical characteristics, such as size or weight, or by biological characteristics, such as expression of epithelial or cancer-specific markers.
Daniel F, Hayes, Jeffrey B, Smerage
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2015
Circulating Tumor Cells (CTC) are shed from primary or secondary tumors. Prior studies have demonstrated that enumeration of CTC is a robust independent prognostic factor of progression free and overall survival in patients with early and metastatic breast cancer.
Costanza, Paoletti, Daniel F, Hayes
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Circulating Tumor Cells (CTC) are shed from primary or secondary tumors. Prior studies have demonstrated that enumeration of CTC is a robust independent prognostic factor of progression free and overall survival in patients with early and metastatic breast cancer.
Costanza, Paoletti, Daniel F, Hayes
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Circulating Tumor Cells Revisited
JAMA, 2010DESPITE THE USE OF MODERN HIGH-RESOLUTION imaging technologies, it is not possible to detect tumor cell metastasis at a single cell level. To date, cancer treatment is initiated only after the clinical presentation of disease. This approach generally is unsuccessful and translates into the dogma that metastasis is a terminal process, generally viewed ...
Massimo, Cristofanilli, Stephan, Braun
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Molecular Diagnosis & Therapy, 2012
Circulating tumor cells (CTCs) are cells of presumed epithelial origin, whose prognostic and predictive value in metastatic cancer patients has recently been demonstrated. To date, the count of CTCs through the CellSearch® system represents a valid approach for monitoring disease status in patients with metastatic colorectal, breast, and prostate ...
GAZZANIGA, PAOLA +5 more
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Circulating tumor cells (CTCs) are cells of presumed epithelial origin, whose prognostic and predictive value in metastatic cancer patients has recently been demonstrated. To date, the count of CTCs through the CellSearch® system represents a valid approach for monitoring disease status in patients with metastatic colorectal, breast, and prostate ...
GAZZANIGA, PAOLA +5 more
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Circulating tumor cells in breast cancer
Current Opinion in Obstetrics & Gynecology, 2008To critically review the latest findings concerning the detection and characterization of circulating tumor cells in breast cancer.Various studies have used different methods and markers for circulating tumor cell detection in breast cancer. Data on the prognostic value of circulating tumor cell monitoring by the CellSearch system are now available in ...
Ignatiadis, Michail +2 more
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Circulating tumor cells: the Grand Challenge
Lab on a Chip, 2011Jaap den Toonder, Lab on a Chip Editorial Board Member, discusses how the field of circulating tumour cells defines one of the Grand Challenges for the microfluidics community.
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Circulating tumor DNA in advanced solid tumors: Clinical relevance and future directions
Ca-A Cancer Journal for Clinicians, 2021Michael L Cheng +2 more
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