Results 181 to 190 of about 5,339,936 (244)

Tyrosine residues at the substrate binding site in human NQO1 homodimer: Protein conformational dynamics and optimization of substrate binding geometry

The FEBS Journal, Volume 293, Issue 17, Page 5255-5281, September 2026.
Human NAD(P)H:quinone oxidoreductase 1 is a homodimeric flavoenzyme crucial for redox metabolism and linked to significant health issues. Point mutations at Tyr126 and Tyr128 demonstrate their essential roles in optimizing substrate binding geometry for catalysis, as well as in half‐site reactivity and conformational dynamics during the enzyme's ...
Maribel Rivero, Juan Luis Pacheco‐Garcia, Pavla Vankova, Dmitry Loginov, Isabel Quereda‐Moraleda, Jose Manuel Martin‐Garcia, Petr Man, Angel Luis Pey, Milagros Medina   +8 more
wiley   +1 more source

Dissecting Molecular Heterogeneity of Circulating Tumor Cells (CTCs) from Metastatic Breast Cancer Patients through Copy Number Aberration (CNA) and Single Nucleotide Variant (SNV) Single Cell Analysis. [PDF]

Cancers (Basel), 2022
Rossi T, Angeli D, Tebaldi M, Fici P, Rossi E, Rocca A, Palleschi M, Maltoni R, Martinelli G, Fabbri F, Gallerani G.   +10 more
europepmc   +1 more source

Carbon Dots for Cancer Theranostics: Synthesis Strategies, Luminescence Properties, and Advances in Bioimaging‐Guided Diagnosis and Therapy

Chemistry – A European Journal, Volume 32, Issue 30, 13 August 2026.
Lighting up the path to precision oncology: This review comprehensively summarizes the rational design of carbon dots (CDs), elucidating how core size, surface chemistry, and heteroatom doping dictate their luminescence mechanisms. Special emphasis is placed on engineering NIR‐II emissive CDs for deep‐tissue imaging.
Zekun Yan, Yupeng Liu, Jinyun Tan, Songnan Qu   +3 more
wiley   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma-cfDNA of advanced breast cancer patients: A feasibility proof-of-concept study. [PDF]

Mol Oncol
Stergiopoulou D, Markou A, Nicolo E, Serafini MS, Zhang Q, Zhang Y, Gerratana L, Davis AA, Liu H, Gradishar WJ, Reduzzi C, Cristofanilli M, Lianidou E.   +12 more
europepmc   +1 more source

Detyrosinated α-Tubulin, Vimentin and PD-L1 in Circulating Tumor Cells (CTCs) Isolated from Non-Small Cell Lung Cancer (NSCLC) Patients. [PDF]

J Pers Med, 2022
Katsarou SD, Messaritakis I, Voumvouraki A, Kakavogiannis S, Κotsakis A, Alkahtani S, Stournaras C, Martin SS, Georgoulias V, Kallergi G.   +9 more
europepmc   +1 more source

Isolation and Molecular Characterization of Circulating Tumor Cells [electronic resource] /

The past decade has seen remarkable progress in elucidating the clinical relevance of circulating tumor cells (CTCs). Evidence from numerous clinical studies has unequivocally demonstrated the importance of CTCs as harbingers of poor outcome.
Magbanua, Mark Jesus M.editor.edthttp://id.loc.gov/vocabulary/relators/edt, Park, John W.editor.edthttp://id.loc.gov/vocabulary/relators/edt, SpringerLink (Online service)   +2 more
core   +1 more source

Circulating tumor cells (CTCs) enumeration and machine-learning based diagnostic biomarkers for breast cancer detection. [PDF]

BMC Cancer
Liu CY, Lin YH, Tsai YF, Lu PY, Chen JL, Li YH, Huang CC, Lin YS, Chao TC, Feng CJ, Hsu CY, Chiu JH, Chen CM, Tseng LM.   +13 more
europepmc   +1 more source

Circulating tumor cells (CTCs)/circulating tumor endothelial cells (CTECs) and their subtypes in small cell lung cancer: Predictors for response and prognosis. [PDF]

Thorac Cancer, 2021
Zhu HH, Liu YT, Feng Y, Zhang LN, Zhang TM, Dong GL, Xing PY, Wang HY, Shi YK, Hu XS.   +9 more
europepmc   +1 more source

Preoperative Circulating Tumor Cells (CTCs) Positivity is Associated with Lymph Node Metastasis in Patients with Unifocal Papillary Thyroid Microcarcinoma (PTMC). [PDF]

Int J Gen Med
Zhong H, Zeng Q, Wang Y, Chen J.
europepmc   +1 more source

Perioperative Circulating Tumor Cells (CTCs), MCTCs, and CTC-White Blood Cells Detected by a Size-Based Platform Predict Prognosis in Renal Cell Carcinoma. [PDF]

Dis Markers, 2021
Wang Z, Zhang P, Chong Y, Xue Y, Yang X, Li H, Wang L, Zhang Y, Chen Q, Li Z, Xue L, Li H, Chong T.   +12 more
europepmc   +1 more source