Results 91 to 100 of about 2,903,919 (287)

Cardiomyocyte overexpression of microRNA-210 mitigates apoptotic cell death induced by doxorubicin

Cardio-Oncology
Background Advancements in cancer diagnostics and treatments have significantly increased patient survival rates. However, these advancements are often accompanied by treatment-induced health issues.
Johan Guthormsen, Mikal Solstad Øiaas, Mido Magdi Allam, Gurdeep Marwarha, Morten Andre Høydal   +4 more
doaj   +1 more source

Purchase, circulation and fuel taxation [PDF]

, 2008
During the last decade, the UK and many other developed nations have reformed existing forms of road transport taxation to address a number of transport policy goals.
Potter, Stephen
core  

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Generative augmentations for improved cardiac ultrasound segmentation using diffusion models

Scientific Reports
One of the main challenges in current research on segmentation in cardiac ultrasound is the lack of large and varied labeled datasets and the differences in annotation conventions between datasets.
Gilles Van De Vyver, Aksel Try Lenz, Erik Smistad, Sindre Hellum Olaisen, Bjørnar Grenne, Espen Holte, Håvard Dalen, Lasse Løvstakken   +7 more
doaj   +1 more source

For Gods\u27 Sake, Copy-edit that Textbook on the Wall [PDF]

, 2014
So, my social streams flooded on Monday with an article from the Denver Business Journal, a weekly Colorado publication with a circulation rate of about 16,000 issues. The internet is an amazingly powerful force for magnification. It can make a rant from
Rudy, John M.
core   +1 more source

Collateral Circulation [PDF]

Stroke, 2003
Background— The collateral circulation plays a pivotal role in the pathophysiology of cerebral ischemia. Current knowledge of the collateral circulation remains sparse, largely because of prior limitations in methods for evaluation of these diminutive routes of cerebral blood flow.
openaire   +2 more sources

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Factors affecting patient outcomes in pulmonary artery thromboendarterectomy under deep hypothermic circulatory arrest and cardiopulmonary bypass support----a single center’s experience

BMC Cardiovascular Disorders
Objective To explore the factors affecting patient outcomes in pulmonary artery thromboendarterectomy (PTE) under deep hypothermic circulatory arrest (DHCA) and cardiopulmonary bypass (CPB) support and to provide a reference for further improving the ...
Ming Guan, Xiaofang Yang, Lin Fu, Xueting Zhao, Feilong Hei   +4 more
doaj   +1 more source

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source