Results 41 to 50 of about 908,418 (219)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Российский кардиологический журнал, 2016 Pulmonary hypertension is an increase of pulmonary artery mean pressure for more than 25 mmHg at rest, measured by direct tensometry, and it includes a broad spectrum of diseases.
S. I. Zheleznev +7 more
doaj +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Effects of mesoscale eddies on intraseasonal variability of intermediate water east of Taiwan
Scientific Reports, 2022 The intraseasonal variability of the intermediate water (IW) and its characteristics east of Taiwan are studied utilizing 17 months of long-term, continuous and synchronous measurements of temperature, salinity and current from mooring sites deployed at ...
Qiang Ren +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
ATRIAL FIBRILLATION AFTER CARDIAC SURGERY: PATHOPHYSIOLOGY AND PREVENTION TECHNIQUES
Вестник анестезиологии и реаниматологии, 2017 Atrial fibrillation is one of the most frequent complications occurring after cardiac surgery. Post-operative atrial fibrillation confidently increases the risk of mortality and associated complications.
V. V. Lomivorotov +3 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
MITRAL VALVE PATHOLOGY IN CONNECTIVE TISSUE DYSPLASIA
Российский кардиологический журнал, 2016 Recently, the main cause of mortality and disability in the world are cardiovascular diseases. By the data from autopsies, valve defects have 4-7% prevalence, and most common are mitral valve defects.
A. V. Bogachev-Prokofiev +7 more
doaj +1 more source
Respiratory Research, 2022 Background Our previous study showed that circular RNA-gamma-secretase-activating protein (circGSAP) was down-regulated in pulmonary microvascular endothelial cells (PMECs) in response to hypoxia, and regulated the cell cycle of PMECs via miR-942-5p ...
Yuanyuan Sun +11 more
doaj +1 more source