Results 41 to 50 of about 1,526,491 (315)

Effect of DFPP on Ferroptosis in Peripheral Blood CD14+ Monocytes of Hyperlipidemic Patients Involving the ACSL4/LPCAT3/ALOX5 Pathway

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng, Lan Li, Qingmei Yang, Meipeng Wu   +3 more
wiley   +1 more source

RADIOFREQUENCY DENERVATION OF PULMONARY ARTERY IN SURGERY OF DYSPLASTIC MITRAL VALVE DEFECTS WITH SEVERE PULMONARY HYPERTENSION

Российский кардиологический журнал, 2016
Pulmonary hypertension is an increase of pulmonary artery mean pressure for more than 25 mmHg at rest, measured by direct tensometry, and it includes a broad spectrum of diseases.
S. I. Zheleznev, D. P. Demidov, A. V. Afanasiev, V. M. Nazarov, I. I. Demin, A. V. Bogachev-Prokofiev, D. A. Astapov, A. M. Karaskov   +7 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Impact of geothermal heating on the global ocean circulation [PDF]

, 2001
The response of a global circulation model to a uniform geothermal heat flux of 50 mW m-2 through the sea floor is examined. If the geothermal heat input were transported upward purely by diffusion, the deep ocean would warm by 1.2°C. However, geothermal
Marotzke, J. ; https://orcid.org/, Marotzke, Jochem, Scott, J., Adcroft, A., Adcroft, Alistair, Scott, Jeffery R.   +5 more
core   +2 more sources

Computed tomographic manifestations of celiac ganglia between hypertensive and non‐hypertensive population

The Journal of Clinical Hypertension, 2023
The celiac ganglion (CG) is associated with the sympathetic nervous system (SNS) and plays an important role in the pathogenesis of hypertension. The characteristics of the CG in patients with hypertension remain unknown.
Wenkai Xiao, Xueying Long, Junyu Chen, Yu Tan, Xunjie Cheng, Li Gong, Xueting Qiu, Tianqi Ma, Yongping Bai, Chuanchang Li   +9 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

ATRIAL FIBRILLATION AFTER CARDIAC SURGERY: PATHOPHYSIOLOGY AND PREVENTION TECHNIQUES

Вестник анестезиологии и реаниматологии, 2017
Atrial fibrillation is one of the most frequent complications occurring after cardiac surgery. Post-operative atrial fibrillation confidently increases the risk of mortality and associated complications.
V. V. Lomivorotov, S. M. Efremov, E. A. Pokushalov, V. A. Boboshko   +3 more
doaj   +1 more source