Results 51 to 60 of about 1,526,491 (315)

Effects of mesoscale eddies on intraseasonal variability of intermediate water east of Taiwan

Scientific Reports, 2022
The intraseasonal variability of the intermediate water (IW) and its characteristics east of Taiwan are studied utilizing 17 months of long-term, continuous and synchronous measurements of temperature, salinity and current from mooring sites deployed at ...
Qiang Ren, Fei Yu, Feng Nan, Yuanlong Li, Jianfeng Wang, Yansong Liu, Zifei Chen   +6 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

MITRAL VALVE PATHOLOGY IN CONNECTIVE TISSUE DYSPLASIA

Российский кардиологический журнал, 2016
Recently, the main cause of mortality and disability in the world are cardiovascular diseases. By the data from autopsies, valve defects have 4-7% prevalence, and most common are mitral valve defects.
A. V. Bogachev-Prokofiev, A. V. Afanasiev, I. Yu. Zhuravleva, D. P. Demidov, S. I. Zheleznev, O. Yu. Malakhova, Ya. V. Syrtseva, A. M. Karaskov   +7 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

CHOICE OF THE IMPLANTABLE SUPPORT RINGS IN CONNECTIVE TISSUE DYSPLASIA AND SEVERE MITRAL REGURGITATION

Российский кардиологический журнал, 2016
Aim. To analyze the results of valve-securing surgery on mitral valve in connective tissue dysplasia.Material and methods. From 2011 to 2014 y., totally 171 patient included, with isolated mitral regurgitation. Patients were randomized to 2 groups.
A. V. Afanasiev, S. I. Zheleznev, A. V. Bogachev-Prokofiev, V. M. Nazarov, I. I. Demin, D. A. Astapov, A. M. Karaskov   +6 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

The General Circulation of the Tropical Atmosphere and Climate Changes [PDF]

, 2012
I examine the general circulation of the tropical atmosphere and climate changes. First, the response of the zonal surface temperature gradients and zonally asymmetric tropical overturning circulations (Walker circulations) to substantial changes in the ...
Merlis, Timothy Moore
core   +1 more source

ROBOTIC INTERVENTIONS IN THORACIC TUMORS (EXPERIENCE OF 30 PRIMARY OPERATIONS)

Вестник хирургии имени И.И. Грекова, 2017
OBJECTIVE. The research evaluated the data of robotic thoracoscopic interventions. MATERIALS AND METHODS. The article presents the results of robotic surgery in 30 patients aged 41 to 78 years with lung tumors of various localization and tumors of ...
A. S. Kudryavtsev, S. V. Yarmoshchuk, A. A. Zheravin, E. A. Drobyazgin, Yu. V. Chikinev   +4 more
doaj   +1 more source

CircGSAP alleviates pulmonary microvascular endothelial cells dysfunction in pulmonary hypertension via regulating miR-27a-3p/BMPR2 axis

Respiratory Research, 2022
Background Our previous study showed that circular RNA-gamma-secretase-activating protein (circGSAP) was down-regulated in pulmonary microvascular endothelial cells (PMECs) in response to hypoxia, and regulated the cell cycle of PMECs via miR-942-5p ...
Yuanyuan Sun, Rong Jiang, Xiaoyi Hu, Sugang Gong, Lan Wang, Wenhui Wu, Jinling Li, Xinyang Kang, Shijin Xia, Jinming Liu, Qinhua Zhao, Ping Yuan   +11 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source