Results 31 to 40 of about 4,739,711 (293)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

"Compensated hyperosmolarity" of cerebrospinal fluid and the development of hydrocephalus [PDF]

, 2013
Acute osmolar loading of cerebrospinal fluid within one lateral ventricle of dogs was examined as a cause of water extraction from the bloodstream and an increase in intracranial pressure.
Vladić, Anton, Klarica, Marijan, Miše, Branko, Radoš, Milan, Orešković, Darko   +4 more
core   +1 more source

A multilevel domain decomposition approach for solving coupled applications in computational fluid dynamics

, 2007
The purpose of this paper is to introduce a flexible and robust multilevel finite element algorithm that can be used to study the behavior of a fully coupled fluid-structure system.
MANSERVISI, SANDRO, P. Seshaiyer, E. Aulisa   +2 more
core   +2 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Higher order dynamic mode decomposition beyond aerospace engineering

Results in Engineering, 2023
It is a well known fact that fluid dynamics play a crucial rule in countless fields in scientific and industrial applications, including nature and medicine (ocean currents, fluid motion around jellyfish, blood circulation...), in energy production (wind
N. Groun, B. Begiashvili, E. Valero, J. Garicano-Mena, S. Le Clainche   +4 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Geothermal Heating and its Influence on the Meridional Overturning Circulation [PDF]

, 2001
The effect of geothermal heating on the meridional overturning circulation is examined using an idealized, coarse-resolution ocean general circulation model.
Jeffery R. Scott, Jochem Marotzke, Alistair Adcroft, Marotzke, J. ; https://orcid.org/, Scott, J., Marotzke, J., Adcroft, A., Scott, J.R.   +7 more
core   +1 more source

Experimental and Numerical Simulation Investigation of Single-Phase Natural Circulation in a Large Scale Rectangular Loop

Atom Indonesia, 2019
In order to anticipate station blackout, the use of safety system based on passive features is highly considered in advanced nuclear power plant designs, especially after the Fukushima Dai-ichi nuclear power station accident.
A.R. Antariksawan, S. Widodo, M. Juarsa, S. Ismarwanti, D. Saptoadi, M.H. Kusuma, T. Ardiyati, T. M.I. Mahlia   +7 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Multisymplectic formulation of fluid dynamics using the inverse map [PDF]

, 2007
13.02.14 KB. Ok to add accepted version to spiral, embargo expired. RS policyWe construct multisymplectic formulations of fluid dynamics using the inverse of the Lagrangian path map.
Cotter, CJ, Hydon, PE, Holm, D D, Holm, DD, Cotter, C J, Hydon, Peter E   +5 more
core   +1 more source