Results 41 to 50 of about 45,939 (308)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Experimental and Numerical Simulation Investigation of Single-Phase Natural Circulation in a Large Scale Rectangular Loop

Atom Indonesia, 2019
In order to anticipate station blackout, the use of safety system based on passive features is highly considered in advanced nuclear power plant designs, especially after the Fukushima Dai-ichi nuclear power station accident.
A.R. Antariksawan, S. Widodo, M. Juarsa, S. Ismarwanti, D. Saptoadi, M.H. Kusuma, T. Ardiyati, T. M.I. Mahlia   +7 more
doaj   +1 more source

Cerebrospinal fluid dynamics along the optic nerve

Frontiers in Neurology, 2022
The cerebrospinal fluid (CSF) plays an important role in delivering nutrients and eliminating the metabolic wastes of the central nervous system. An interrupted CSF flow could cause disorders of the brain and eyes such as Alzheimer's disease and glaucoma.
Jinqiao Sheng, Jinqiao Sheng, Qi Li, Tingting Liu, Xiaofei Wang   +4 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

A Novel Approach to Investigating Transport of Lost Circulation Materials in Rough Fracture

Energies, 2018
The drilling fluid loss or lost circulation via fractures is one of the critical engineering problems in the development of deep oil and gas resources. The conventional treatment is to introduce granular lost circulation material (LCM) into the drilling ...
Yi Feng, Gao Li, Yingfeng Meng, Boyun Guo   +3 more
doaj   +1 more source

Intermittency of Velocity Circulation in Quantum Turbulence

Physical Review X, 2021
The velocity circulation, a measure of the rotation of a fluid within a closed path, is a fundamental observable in classical and quantum flows. It is indeed a Lagrangian invariant in inviscid classical fluids. In quantum flows, circulation is quantized,
Nicolás P. Müller, Juan Ignacio Polanco, Giorgio Krstulovic   +2 more
doaj   +1 more source

Computational fluid dynamic simulations of a cavopulmonary assist device for failing Fontan circulation [PDF]

The Journal of Thoracic and Cardiovascular Surgery, 2019
Adult patients who have undergone the Fontan procedure are highly vulnerable to gradual, progressive circulatory failure, and options to reverse this situation are few. A cavopulmonary assist device could decongest the venous and lymphatic systems, overcome elevated pulmonary vascular resistance, increase cardiac output, and support some of these ...
Lin, W C Patrick, Doyle, Matthew G, Roche, S Lucy, Honjo, Osami, Forbes, Thomas L, Amon, Cristina H   +5 more
openaire   +3 more sources

Computational fluid dynamics dataset of secondary air modification in a circulating fluidized bed boiler

Data in Brief, 2023
Computer simulation has been proven to provide a good understanding of engineering phenomenon. This work presents numerical simulation results on secondary air jet penetration into a dense phase of a three-dimensional fluidized bed at a commercial scale.
Nurdin Hasananto Teguh, Lilis Yuliati, Eko Siswanto, Djarot B. Darmadi   +3 more
openaire   +3 more sources

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Emergence of decadal linkage between Western Australian coast and Western–central tropical Pacific

Nature Communications
The impact of interbasin linkage on the weather/climate and ecosystems is significantly broader and profounder than that of only appearing in an individual basin. Here, we reveal that a decadal linkage of sea surface temperature (SST) has emerged between
Yuewen Ding, Pengfei Lin, Hailong Liu, Bo Wu, Yuanlong Li, Lin Chen, Lei Zhang, Aixue Hu, Yiming Wang, Yiyun Yao, Bowen Zhao, Wenrong Bai, Weiqing Han   +12 more
doaj   +1 more source