A novel quantitative method using Indocyanine Green (ICG) fluorescence image for assessing organ viability during hypothermic oxygenated machine perfusion (HOPE), specifically focusing on homogeneous flow distribution analyzed with the gray‐scale level co‐occurrence matrix (GLCM) method, can predict portal vein resistance induced by ischemic ...
Yuga Okazawa +10 more
wiley +1 more source
The role of cardiopulmonary bypass in the management of retrohepatic vena cava injury - A case report and review of the literature [PDF]
Injuries to the retrohepatic vena cava are extremely rare and are associated with an operative mortality of up to 50% even in high volume trauma centres.
Wilson, Colin H. +3 more
core +1 more source
Brain strain: Blood flow and metabolism in environmental extremes
Abstract This narrative review compares and contrasts the most commonly encountered environmental stressors on human cerebrovascular functioning. From high altitude and space, extreme apnoea, heat and cold stress, the impact of these stressors on the regulation of cerebral blood flow (CBF) and oxygen metabolism (CMRO2${\mathrm{CM}}{{\mathrm{R}}_ ...
Dario Vrdoljak +3 more
wiley +1 more source
The feasibility of performing a randomised controlled trial of therapeutic hypothermia for neuroprotection after paediatric cardiac arrest in the UK [PDF]
Cardiac arrest in paediatric patients often results in death or survival with severe brain injury. Therapeutic hypothermia, lowering of core body temperature to 32 to 34⁰C may reduce injury to the brain in the period after circulation has been restored.
Scholefield, Barnaby R.
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European society of intensive care medicine study of therapeutic hypothermia (32-35 °C) for intracranial pressure reduction after traumatic brain injury (the Eurotherm3235Trial). [PDF]
BACKGROUND: Traumatic brain injury is a major cause of death and severe disability worldwide with 1,000,000 hospital admissions per annum throughout the European Union.Therapeutic hypothermia to reduce intracranial hypertension may improve patient ...
Mascia, L +89 more
core +4 more sources
This study provides the first intra‐individual, regional single‐cell comparison of main/lobar versus bifurcate pulmonary endarterectomy (PEA) specimens. It reveals distinct macrophage polarisation, divergent T‐cell compositions and pronounced smooth muscle cell (SMC)‐to‐myofibroblast transition in the bifurcate region. These findings highlight regional
Rui Zhang +12 more
wiley +1 more source
Monocyte inflammation and adaptive immune dysfunction in severe Klebsiella pneumoniae pneumonia
Severe Klebsiella pneumoniae pneumonia combines intense inflammation with failure to control infection, yet the cellular basis is unclear. Using a severity‐focused single‐cell atlas of 708,894 peripheral blood mononuclear cells from 100 individuals, complemented by plasma protein measurements and flow cytometry, we show that disease severity redirects ...
Hongquan Chen +23 more
wiley +1 more source
Current conduct of deep hypothermic circulatory arrest in China.
IntroductionDeep hypothermic circulatory arrest for adult aortic arch repair is still associated with significant mortality and morbidity. Furthermore, there is still significant variation in the conduct of this complex perioperative technique.
Choi, J +5 more
core +1 more source
Cooling down for going up: Could selective ‘brain chilling’ mitigate high‐altitude illness?
Experimental Physiology, EarlyView.
Adnan Haq, Damian M. Bailey
wiley +1 more source
After the development of deep hypothermia and circulatory arrest for cardiothoracic procedures in the late 1950s, this technique was adopted by several neurosurgeons as an aid to complex cranial surgery.
Rothoerl, RD;Brawanski, A
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