Results 91 to 100 of about 147,027 (291)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
UNPREDICTABILITY IN THE LOAN CONTRACT [PDF]
Challenges of the Knowledge Society, 2019 Referring to the conditions of the unpredictability to the substantive elements of the loan agreement, it can be observed that this institution could intervene when the exceptional circumstance of its essence would affect the object of the contract ...
Georgiana COMAN
doaj
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
The Effect of Academic Circumstance on Substance Use and Exercise
, 2015 The present study evaluated academic circumstance as a predictor of exercise and substance use as it is related to grade point average (GPA). Herrman, Schuckit, Hineman, and Pugh (1976) observed the effects of stress on drug use and GPA.
Rivera, Steven +2 more
core +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Exceptional circumstances [PDF]
American Journal of Orthodontics and Dentofacial Orthopedics, 2020 openaire +2 more sources
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Poverty - Fatality or circumstance? The principle of “take-off” from poverty
Annals of Spiru Haret University Economic Series, 2011 Poverty is one of the most challenging issues to be addressed by contemporary society. Although it could be considered as a legacy of previous era and it was addressed by a wide range of experts, a meaningful solution is still to come. The paper looks to
Florina BRAN, Gheorghe MANEA
doaj