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Medical Clinics of North America, 2022 Cirrhosis is a chronic condition resulting from inflammation and fibrosis of the liver. Patients with cirrhosis may have a myriad of physical examination findings that reflect the severity of the underlying liver disease. Although many signs and symptoms related to cirrhosis are nonspecific, such as abdominal pain, nausea, and malaise, some findings ...
Rachel, Wilson, Donna M, Williams
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The stratification of cirrhosis [PDF]
Hepatology Research, 2020 Cirrhosis is traditionally seen as an irreversible stage of chronic liver disease although its clinical course may last several years. Overall, the clinical management of patients with cirrhosis is based on the observation of clinical events mostly related to complications of portal hypertension.
Maurice, J, Pinzani, M
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Influence of portal vein occlusion on portal flow and liver elasticity in an animal model [PDF]
NMR in Biomedicine, Wiley, 2021, pp.e4498, 2021 Hepatic fibrosis causes an increase in liver stiffness, a parameter measured by elastography and widely used as a diagnosis method. The concomitant presence of portal vein thrombosis (PVT) implies a change in hepatic portal inflow that could also affect liver elasticity.
arxiv +1 more source
Current Treatment Options in Gastroenterology, 2019 Patients with cirrhosis are at high risk of developing serious infections. Bacterial infections remain the most common cause of morbidity and mortality in these patients. This review is focused on the prevalence of infections in those with cirrhosis, including multidrug-resistant (MDR) pathogens, pathogenesis of infection-related acute-on-chronic liver
K. Rajender Reddy, Sirina Ekpanyapong
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Hyponatraemia and cirrhosis [PDF]
Gastroenterology Report, 2014 Hyponatraemia is a common complication of advanced cirrhosis related to an impairment in the renal capacity for eliminating solute-free water, causing a retention of water that is disproportionate to the retention of sodium, thus leading to a reduction in serum sodium concentration and hypo-osmolality.
Andrés Cárdenas, Robert J. Gianotti
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Hypotension in Cirrhosis [PDF]
Clinical Liver Disease, 2019 Circulatory and cardiac compromise in cirrhosis has been well studied. The primary pathophysiology stems from portal hypertension, which is induced from an increased resistance to flow secondary to distorted sinusoidal architecture and is further sustained from an increase in portal venous flow.1 Portal hypertension induces both progressive splanchnic ...
Ravi Vora, Ram Subramanian
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Exploring novel prognostic biomarkers and biologic processes involved in NASH, cirrhosis and HCC based on survival analysis using systems biology approach [PDF]
arXiv, 2023 There is an unmet need to develop medications or drug combinations which can stop advancement of NASH to liver cirrhosis and HCC. Therefore, identifying key biomarkers based on overall survival and the exploring biological processes involved in the pathogenesis and progression of NASH toward cirrhosis and HCC to improve therapeutic interventions is ...
arxiv
Primary Biliary Cirrhosis [PDF]
New England Journal of Medicine, 1987 No ...
Roblin, Xavier, Bonaz, Bruno
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Learning to diagnose cirrhosis from radiological and histological labels with joint self and weakly-supervised pretraining strategies [PDF]
arXiv, 2023 Identifying cirrhosis is key to correctly assess the health of the liver. However, the gold standard diagnosis of the cirrhosis needs a medical intervention to obtain the histological confirmation, e.g. the METAVIR score, as the radiological presentation can be equivocal.
arxiv
Journal of Clinical and Experimental Hepatology, 2022 Fatigue is a common symptom in patients with liver disease and has a significant impact on the health-related quality of life (HR-QoL). Its pathogenesis is poorly understood and is considered multifactorial. The liver is central in the pathogenesis of fatigue because it uniquely regulates much of the production, storage, and release of substrate for ...
Krishnagopal Bhandari, Dharmesh Kapoor
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