Results 201 to 210 of about 680,529 (391)

Manganese Neurotoxicity and Familial Disorders of Manganese Transport

open access: yesAnnals of the Child Neurology Society, EarlyView.
ABSTRACT Manganese is the 12th most common element in the Earth's crust and is an essential industrial component. Biologically, this metal plays an important role as a constituent of numerous enzymes. While manganese is required for normal biochemical and physiological processes, manganese excess can lead to significant toxicity, particularly to the ...
Sidney M. Gospe Jr.
wiley   +1 more source

Identification of novel neutralizing determinants for protection against HCV

open access: yesHepatology, EarlyView., 2022
Identification of novel neutralizing determinants for protection against hepatitis C virus. Abstract Background and Aims HCV evasion of neutralizing antibodies (nAb) results in viral persistence and poses challenges to the development of an urgently needed vaccine.
Garazi P. Alzua   +12 more
wiley   +1 more source

Synchronous double primary hepatocellular carcinoma and intrahepatic cholangiocarcinoma in a single patient with chronic hepatitis B: two case reports and literature review

open access: yesFrontiers in Oncology
Simultaneous occurrence of primary hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) is rare. We report two cases of synchronous double primary HCC and ICC (sdpHCC-ICC), both associated with chronic hepatitis B.
Pengcheng Wei   +21 more
doaj   +1 more source

Model‐Informed Drug Development Applications and Opportunities in mRNA‐LNP Therapeutics

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
The utilization of lipid nanoparticles (LNP) for encapsulating mRNA has revolutionized the field of therapeutics, enabling the rapid development of COVID‐19 vaccines and cancer vaccines. However, the clinical development of mRNA‐LNP therapeutics faces numerous challenges due to their complex mechanisms of action and limited clinical experience.
Jiawei Zhou   +6 more
wiley   +1 more source

A shared mucosal gut microbiota signature in primary sclerosing cholangitis before and after liver transplantation

open access: yesHepatology, EarlyView., 2022
In this study of the gut mucosal microbiota in primary sclerosing cholangitis (PSC), we found consistent microbiota features associated with PSC and recurrent PSC, PSC with inflammatory bowel disease and a persistent gut dysbiosis after liver transplantation Abstract Background and Aims Several characteristic features of the fecal microbiota have been ...
Mikal Jacob Hole   +12 more
wiley   +1 more source

The role of atrial natriuretic peptide (ANP) in chronic liver disease. [PDF]

open access: yes, 1993
Almeida   +82 more
core   +1 more source

Late Pleistocene to Holocene sedimentation in the Great Blue Hole (Lighthouse Reef, Belize): Results from a 30 m long core

open access: yesThe Depositional Record, EarlyView.
A 30 m long sedimentary succession at the bottom of the Belize Blue Hole represents terrestrial cenote (12.5–7.2 ka BP), restricted marine swamp (7.2–5.7 ka BP) and fully marine lagoonal phases (5.7–0 ka BP) on Lighthouse Reef carbonate platform. Post‐glacial and Holocene sea‐level rise largely controlled the sedimentological, faunal and floral changes
Eberhard Gischler   +12 more
wiley   +1 more source

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