Results 71 to 80 of about 699,669 (281)

Effects of short- and long-chain fatty acids on the expression of stearoyl-CoA desaturase and other lipogenic genes in bovine mammary epithelial cells

Animal, 2013
Stearoyl-CoA desaturase (SCD) in the bovine mammary gland introduces a cis-double bond at the Δ9 position in a wide range of fatty acids (FA). Several long-chain polyunsaturated fatty acids (PUFA) inhibit expression of SCD, but information on the effect ...
A.A.A. Jacobs, J. Dijkstra, J.S. Liesman, M.J. VandeHaar, A.L. Lock, A.M. van Vuuren, W.H. Hendriks, J. van Baal   +7 more
doaj   +1 more source

cis-6-Methoxycarbonyl-2,10-dioxa-1-phosphabicyclo[4.4.0]decane 1-Oxide [PDF]

, 1995
The crystal structure of the title compound, C9H1505P, is described. The molecule consists of two cis-fused six-membered rings, both in the chair conformation.
Bennett, Dennis W., Cremer, Sheldon E., Lane, Thomas M., Rodriguez, Oscar P, Sommese, Anthony Gerard   +4 more
core   +1 more source

Excited States of Proton-bound DNA/RNA Base Homo-dimers: Pyrimidines [PDF]

, 2014
We are presenting the electronic photo fragment spectra of the protonated pyrimidine DNA bases homo-dimers. Only the thymine dimer exhibits a well structured vibrational progression, while protonated monomer shows broad vibrational bands. This shows that
Adesokan A. a, Ahlrichs R., Alata I., Alata I., Alata I., Alata I., Andersen L. H., Bakker J. M., Berdakin M., Berdakin M., Bouchoux G., Boyarkin O. V., Brøndsted Nielsen S., Chakraborty S., Christophe Jouvet, Claude Dedonder-Lardeux, Delchev V. B., Dopfer O., Duncan M. A., Fonseca Guerra C., Fridgen T. D., Féraud G., Féraud G., Gehring K., Grégoire G., Gustavo A. Pino, Géraldine Féraud, Góra R. W., Hattig C., Kamrath M. Z., Kamrath M. Z., Kang H., Kang H., Kang H., Kleinermanns K., Le Barbu-Debus K., Lepere V., Lieblein A. L., Marian C., Matias Berdakin, Mercier S. R., Patzer A., Pino G. A., Rajabi K., Saigusa H., Salpin J.-Y., Schermann J.-P., Schirmer J., Scuderi D., Scuderi D., Sobolewski A. L., Solcà N., Wang X. B., Yang B., Yang B., Škríba A.   +55 more
core   +5 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Altered expressions of Notch-1 signaling proteins and beta-catenin in progression of carcinoma in situ into squamous carcinoma of uterine cervix

Indian Journal of Pathology and Microbiology, 2017
Background: Activation of Notch-1 signaling pathway and loss of membranous beta-catenin have been known to play key roles in the progression of uterine cervix cancer and thus this study focused any alteration in the expression patterns for Notch-1, p53 ...
Na-Hye Myong
doaj   +1 more source

Site-specific DNA oxidation by a dinuclear copper complex containing a photoisomerizable azobenzene ligand [PDF]

, 2013
A dinuclear copper complex possessing an azobenzene backbone (Cu^[II]_[2]1) was synthesized and its affinity towards DNA was investigated and found to be dependent on the trans–cis isomeric forms. Upon exposure to UV light at 365 nm the trans form of the
Akamatsu, Kanako, Ito, Takeo, Nishimoto, Sei-ichi, Satani, Manami, Takeuchi, Kouhei, Tanabe, Kazuhito   +5 more
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

cis-2-(4-Methoxyphenyl)-4-methyl-1,2-dihydronaphthalen-1-ol

Acta Crystallographica Section E, 2014
The stereochemistry and regiochemistry of the title compound, C18H18O2, were determined by the X-ray analysis. There are two independent molecules in the asymmetric unit in which the dihedral angles between the benzene rings are 88.31 (4) and 86.27 (4)°.
Alan J. Lough, Mohammed-Abdul Raheem, William Tam   +2 more
doaj   +1 more source

Modelling the overdiagnosis of breast cancer due to mammography screening in women aged 40 to 49 in the United Kingdom [PDF]

, 2012
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, andreproduction in any medium, provided the original work ...
AH Olsen, BN Hellquist, C Biesheuvel, CT Brekelmans, D Puliti, E Paci, H Weedon-Fekjaer, HJ de Koning, HP Sinn, KJ Jørgensen, L Tabár, MF Yen, Montserrat Garcia-Closas, Necdet B Gunsoy, Office for National Statistics, Office for National Statistics, PA Carney, R de Gelder, S Moss, S Moss, S Moss, Sue M Moss, SW Duffy, SW Duffy, SW Duffy, SW Duffy, TC Prevost   +26 more
core   +2 more sources