Results 81 to 90 of about 699,669 (281)

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Siklohekzen ve Siklohekzadienlerden Bromosiklitollerin Sentezi

Journal of Ata-Chem
Siklitoller, önemli biyolojik aktiviteleri nedeniyle yoğun şekilde araştırılan bileşiklerdir. Bu çalışmada, siklohekzen, 1,3-siklohekzadien ve 1,4-siklohekzadien temel alınarak yeni bromosiklitol analoglarının sentezi gerçekleştirildi. cis-Hidroksilleme,
Süleyman Göksu, Hasan Seçen, Hülya Çelik   +2 more
doaj   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Scaling of Level Statistics at the Disorder-Induced Metal-Insulator Transition

, 1995
The distribution of energy level separations for lattices of sizes up to 28$\times$28$\times$28 sites is numerically calculated for the Anderson model. The results show one-parameter scaling.
A. Mac, A.G. Aronov, B. Kramer, B.L. Altshuler, B.L. Altshuler, E. Hofstetter, E.P. Wigner, E.P. Wigner, F.J. Dyson, F.J. Dyson, I. Kh. Zharekeshev, J.K. Cullum, M.L. Mehta, S.N. Evangelou, S.N. Evangelou   +14 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Evaluation of the penetration capacity of bacteria through layers of different face mask types and wearing conditions

Scientific Reports
The aim of this study was to quantify the number of non-airborne bacteria that can passively penetrate the layers of four mask types (surgical mask, community face mask type 1 (CFM1), biocidal CFM1 and CFM2) and to determine the influence of wearing ...
Alice Kheng, Lara Leclerc, Martin Fayolle, Florence Grattard, Paul O. Verhoeven, Jérémie Pourchez   +5 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Thy-1 in Integrin Mediated Mechanotransduction

Frontiers in Cell and Developmental Biology, 2019
The glycosylphosphatidylinositol (GPI) anchored glycoprotein Thy-1 has been prevalently expressed on the surface of various cell types. The biological function of Thy-1 ranges from T cell activation, cell adhesion, neurite growth, differentiation ...
Ping Hu, Thomas H. Barker
doaj   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Correlations between SmCPS1 promoter polymorphism and tanshinone contents in Salvia miltiorrhiza

Czech Journal of Genetics and Plant Breeding, 2018
Copalyl diphosphate synthase 1 (SmCPS1) is the first committed enzyme in tanshinone biosynthesis. The promoter region plays an important role in the transcriptional regulation of genes.
Ying SUN, Xin CHEN, Xiao-Yan GAN, Zhu-Yun YAN, Di-Xiu MU, Qing-Rong WANG   +5 more
doaj   +1 more source