Results 41 to 50 of about 764,845 (266)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Conversión de un rectificador para su empleo como fuente de un horno para la producción de consumibles aplicables a la reparación y mantenimiento en la industria azucarera

Revista Centro Azúcar, 2009
El presente trabajo ofrece una solución que permite utilizar un rectificador de soldadura del tipo BDU-506 04, que se encontraba inhabilitado para el servicio, como fuente de energía para un horno por arco eléctrico, para el procesamiento pirometalúrgico
Alexis Delgado Gómez, Amado Cruz-Crespo, Félix Ramos Morales, Lorenzo Perdomo González, Eduardo Díaz Cedré   +4 more
doaj  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

The Principle of Accessibility of State and Municipal Services: Legal Regulation and Realization

Управленческое консультирование
The purpose of the work is to consider the principle of accessibility in the specialized and scientific literature, an attempt was made to formulate: a definition of the principle of accessibility of state and municipal services; a definition of the ...
S. L. Sergevnin, I. S. Alekhina, A. K. Soloveva   +2 more
doaj   +1 more source

Solubility of Cis, Cis-Muconic Acid in Various Polar Solvents from 298.15 K to 348.15 K [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2017
The present work concerns with an investigation on the solubility of cis,cis-muconic acid dissolution in different polar solvents by characterizing and modeling the dissolution as a function of temperature. Water, ethanol, 2-propanol and acetic acid have
Simone Scelfo, Raffaele Pirone, Nunzio Russo   +2 more
doaj  

Prospects of Cooperation in the Commonwealth of Independent States [PDF]

Современная Европа
The modern world is going through global changes that to some extent affect all nations. The goals, institutions and principles that were considered to be the basis of international relations have turned out to be unstable and often discredited.
Anita S. Rypnevskaya
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Competitiveness of Solar and Wind Power Plants in the Countries of the Commonwealth of Independent States

Известия высших учебных заведений и энергетических объединенний СНГ: Энергетика, 2020
Techno-economic indicators of renewable (solar and wind) and non-renewable energy sources are systematized, taking into account the interval of their uncertainty for the conditions of the countries of the Commonwealth of Independent States (CIS).
O. V. Marchenko, S. V. Solomin
doaj   +1 more source