Results 251 to 260 of about 256,231 (309)
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Essays in Biochemistry, 1999
Cisplatin is a widely used anti-cancer drug that is exceptionally effective against testicular cancer. trans-DDP, the geometric isomer of cisplatin, is ineffective as a chemotherapeutic agent. The anti-tumour activity of cisplatin is generally attributed to its formation of DNA adducts, both intrastrand and interstrand crosslinks, which induce ...
E E, Trimmer, J M, Essigmann
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Cisplatin is a widely used anti-cancer drug that is exceptionally effective against testicular cancer. trans-DDP, the geometric isomer of cisplatin, is ineffective as a chemotherapeutic agent. The anti-tumour activity of cisplatin is generally attributed to its formation of DNA adducts, both intrastrand and interstrand crosslinks, which induce ...
E E, Trimmer, J M, Essigmann
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Annals of Internal Medicine, 1988
Excerpt To the editor: Hutchinson and associates (1) reported renal salt wasting in 7 of 70 patients treated with cisplatin.
X, Mariette +5 more
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Excerpt To the editor: Hutchinson and associates (1) reported renal salt wasting in 7 of 70 patients treated with cisplatin.
X, Mariette +5 more
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Toxicology Letters, 1989
Cisplatin is used widely in the treatment of a large number of carcinomas. The clinical use of cisplatin, however, can be complicated by myelotoxicity, ototoxicity and intestinal toxicity; we review briefly cisplatin nephrotoxicity. The principal route of its excretion is via the kidney, and accumulation of cisplatin in the renal cortex has been ...
J P, Fillastre, G, Raguenez-Viotte
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Cisplatin is used widely in the treatment of a large number of carcinomas. The clinical use of cisplatin, however, can be complicated by myelotoxicity, ototoxicity and intestinal toxicity; we review briefly cisplatin nephrotoxicity. The principal route of its excretion is via the kidney, and accumulation of cisplatin in the renal cortex has been ...
J P, Fillastre, G, Raguenez-Viotte
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Liposomal cisplatin: a new cisplatin formulation
Anti-Cancer Drugs, 2010Over the last three decades, cisplatin has been one of the most effective cytotoxic agents, but its administration has been hindered by its nephrotoxicity, neurotoxicity and myelo toxicity. Recently, liposomal cisplatin, lipoplatin, has been formulated and tested thoroughly in preclinical (in vitro) and phase I, II and III trials, as documented in the ...
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International Journal of Andrology, 1987
Ototoxicity is one of the unwanted side effects of cisplatin treatment. The first sign of hearing loss usually appears 3–4 days after the drug administration and occurs primarily in the higher frequencies. One hundred and eighty‐six women treated with a moderate dose of cisplatin (50 mg/m2every 4 weeks) for gynaecological cancer were studied.
G, Laurell +3 more
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Ototoxicity is one of the unwanted side effects of cisplatin treatment. The first sign of hearing loss usually appears 3–4 days after the drug administration and occurs primarily in the higher frequencies. One hundred and eighty‐six women treated with a moderate dose of cisplatin (50 mg/m2every 4 weeks) for gynaecological cancer were studied.
G, Laurell +3 more
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Cancer Treatment Reviews, 1999
Hypomagnesemia is a well known side-effect in patients receiving cisplatin-containing chemotherapy. Cisplatin induces hypomagnesemia through its renal toxicity possibly by a direct injury to mechanisms of magnesium reabsorption in the ascending limb of the loop of Henle as well as the distal tubule.
H, Lajer, G, Daugaard
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Hypomagnesemia is a well known side-effect in patients receiving cisplatin-containing chemotherapy. Cisplatin induces hypomagnesemia through its renal toxicity possibly by a direct injury to mechanisms of magnesium reabsorption in the ascending limb of the loop of Henle as well as the distal tubule.
H, Lajer, G, Daugaard
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Seminars in Nephrology, 2003
Cisplatin remains a major antineoplastic drug for the treatment of solid tumors. Its chief dose-limiting side effect is nephrotoxicity, which evolves slowly and predictably after initial and repeated exposure. The kidney accumulates cisplatin to a higher degree than other organs perhaps via mediated transport.
Istvan, Arany, Robert L, Safirstein
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Cisplatin remains a major antineoplastic drug for the treatment of solid tumors. Its chief dose-limiting side effect is nephrotoxicity, which evolves slowly and predictably after initial and repeated exposure. The kidney accumulates cisplatin to a higher degree than other organs perhaps via mediated transport.
Istvan, Arany, Robert L, Safirstein
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