Results 31 to 40 of about 426,371 (334)

Targeting nitrative stress for attenuating cisplatin-induced downregulation of cochlear LIM domain only 4 and ototoxicity

Redox Biology, 2016
Cisplatin-induced ototoxicity remains a primary dose-limiting adverse effect of this highly effective anticancer drug. The clinical utility of cisplatin could be enhanced if the signaling pathways that regulate the toxic side-effects are delineated.
Samson Jamesdaniel, Rajamani Rathinam, William L. Neumann   +2 more
doaj   +1 more source

Valproic acid treatment attenuates cisplatin‐induced kidney injury by suppressing proximal tubular cell damage

Clinical and Translational Science, 2023
Cisplatin treatment is effective against several types of carcinomas. However, it frequently leads to kidney injury, which warrants effective prevention methods.
Toshihiko Yoshioka, Mitsuhiro Goda, Masaya Kanda, Sayuri Itobayashi, Yugo Sugimoto, Yuki Izawa‐Ishizawa, Kenta Yagi, Fuka Aizawa, Koji Miyata, Takahiro Niimura, Hirofumi Hamano, Takumi Sakurada, Yoshito Zamami, Keisuke Ishizawa   +13 more
doaj   +1 more source

Cisplatin-induced emesis: systematic review and meta-analysis of the ferret model and the effects of 5-HT3 receptor antagonists [PDF]

, 2010
PURPOSE: The ferret cisplatin emesis model has been used for ~30 years and enabled identification of clinically used anti-emetics. We provide an objective assessment of this model including efficacy of 5-HT(3) receptor antagonists to assess its ...
A Fink-Jensen, A Lehmann, A Ozaki, AG King, AH Lau, AL Harris, AM Holmes, AP Florczyk, AP Florczyk, B Costall, B Costall, B Costall, B Costall, B Costall, B Costall, B Lasheras, C Bountra, C. C. Apfel, CJ Gardner, CJ Gardner, CJ Gardner, CL Gooch, D Moher, D Spina, D Tattersall, D Tattersall, DG Altman, DJ Reynolds, DR Gandara, E Blum, E Chevalier, F Roila, FD Tattersall, FD Tattersall, FD Tattersall, GA Higgins, GJ Hollingworth, H Nakayama, H Yamakuni, H Yamakuni, HE Marr, HE Marr, HE Marr, HL Borison, I Angel, I Monkovic, IT Jantunen, J Bermudez, J Hawthorn, J Horn, J Horn, J. A. Rudd, JA Gylys, JA Rudd, JA Rudd, JA Rudd, JA Rudd, JA Rudd, JA Rudd, JA Rudd, JA Rudd, JA Rudd, JA Rudd, JA Rudd, JA Rudd, JA Rudd, JE Schurig, JH Kim, JJ Hale, JJ Hale, JM Barnes, JN Matthews, JW Watson, K Haga, K Haga, L Singh, LE McCarthy, LR Fitzpatrick, LX Cubeddu, M Martin, M Marty, M Minami, M Minami, M Minami, M Ohta, M Tsuchiya, MD Sickle Van, MG Kris, MG Kris, MR Macleod, MR Macleod, MR Macleod, MT Price, N Fukunaka, N Percie du Sert, N Yoshida, N Yoshida, N Yoshida, N Yoshida, N. Percie du Sert, NM Barnes, NM Barnes, NM Rupniak, P Bhandari, P Delagrange, P Pound, P Preziosi, P Ruff, P. L. R. Andrews, PJ Hesketh, PJ Hesketh, PLR Andrews, PLR Andrews, PR Blower, R DerSimonian, R Hargreaves, R Stables, RA Matthews, RC Miller, RD Clark, RD Youssefyeh, RD Youssefyeh, RM Eglen, RM Eglen, RM Eglen, RM Navari, S Bingham, S Gonsalves, S Taniguchi, T Endo, T Endo, T Endo, T Endo, T Endo, T Ito, T Kamato, T Kamato, T Matsui, T Yoshikawa, T Yoshikawa, T Yoshikawa, TM Dando, TS Sam, TS Sam, TS Sam, V Bebarta, WD Miner, WD Miner, WD Miner, Y Kubota, Y Shiroshita, Y Shiroshita, Y Watanabe, YL Liu   +153 more
core   +2 more sources

PERBANDINGAN KEJADIAN LEUKOPENIA DAN TROMBOSITOPENIA PADA PENDERTIA KARSINOMA NASOFARING YANG MENDAPATKAN KEMOTERAPI PACLITAXEL CISPLATIN DAN CISPLATIN 5-FLUOROURACIL (5-FU)

Jurnal Kedokteran Diponegoro, 2019
Latar Belakang : Karsinoma Nasofaring (KNF) merupakan karsinoma yang muncul pada daerah nasofaring. Kemoterapi adalah segolongan obat-obatan yang dapat menghambat pertumbuhan kanker atau bahkan membunuh sel kanker.
Nadya Tara Audina, Willy Yusmawan, Zulfikar Naftali, Suprihati Suprihati   +3 more
doaj   +1 more source

Controlling platinum, ruthenium, and osmium reactivity for anticancer drug design [PDF]

, 2009
The main task of the medicinal chemist is to design molecules that interact specifically with derailed or degenerating processes in a diseased organism, translating the available knowledge of pathobiochemical and physiological data into chemically ...
Bruijnincx, Pieter C. A., Sadler, P. J.
core   +1 more source

MutS homologue hMSH5: role in cisplatin-induced DNA damage response

Molecular Cancer, 2012
Background Cisplatin (cis-diamminedichloroplatinum (II), CDDP) and its analogues constitute an important class of anticancer drugs in the treatment of various malignancies; however, its effectiveness is frequently affected by mutations in genes involved ...
Tompkins Joshua D, Wu Xiling, Her Chengtao   +2 more
doaj   +1 more source

Are serial CA 19-9 kinetics helpful in predicting survival in patients with advanced or metastatic pancreatic cancer treated with gemcitabine and cisplatin? [PDF]

, 2003
Background: Serial kinetics of serum CA 19-9 levels have been reported to reflect response and survival in patients with pancreatic cancer undergoing surgery, radiotherapy, and chemotherapy.
Garbrecht, M., Heinemann, Volker, Helmberger, T., Lamerz, Rolf, Niebler, K., Schalhorn, A., Schermuly, M. M., Stemmler, J., Stieber, P., Stoffregen, C., Szymala, A. M., Wilkowski, R.   +11 more
core   +1 more source

Cisplatin-Based Chemotherapy for Pulmonary Metastasized Germ Cell Tumors of the Testis - Be Aware of Acute Respiratory Distress Syndrome [PDF]

, 2009
Background: Cisplatin-based combination chemotherapy is regarded as standard of care for patients with advanced germ cell tumors. In patients with lung metastases and a high tumor load, an association between induction chemotherapy and the development of
Baumann, Anja, Boeck, Stefan, Gallmeier, Eike, Hausmann, Andreas, Metzeler, Klaus H., Parhofer, Klaus G., Stemmler, Hans-Joachim   +6 more
core   +1 more source

PD‐0332991 combined with cisplatin inhibits nonsmall cell lung cancer and reversal of cisplatin resistance

Thoracic Cancer, 2021
Background: Acquired resistance of chemotherapy, especially cisplatin, is a major challenge in lung cancer treatment. We conducted this study to examine whether a cyclin D kinase 4/6 (CDK4/6) inhibitor, PD 0332991, could reverse cisplatin resistance in ...
Minghui Liu, Liyuan Cui, Xin Li, Chunqiu Xia, Yongwen Li, Rui Wang, Fan Ren, Hongyu Liu, Jun Chen   +8 more
doaj   +1 more source

Association of ABCB1, 5-HT3B receptor and CYP2D6 genetic polymorphisms with ondansetron and metoclopramide antiemetic response in Indonesian cancer patients treated with highly emetogenic chemotherapy. [PDF]

, 2011
Our study shows that in Indonesian cancer patients treated with highly cytostatic emetogenic, carriership of the CTG haplotype of the ABCB1 gene is related to an increased risk of delayed chemotherapy-induced nausea and ...
Baak-Pablo, Renee F, Gelderblom, Hans, Guchelaar, Henk-Jan, Hakimi, Mohammad, Mustofa, Mustofa, Nortier, Johann W R, Perwitasari, Dyah A, van der Straaten, Robert J H M, Wessels, Judith A M   +8 more
core   +2 more sources