Results 11 to 20 of about 366,991 (303)

Understanding cisplatin resistance using cellular models [PDF]

, 2007
Many mechanisms of cisplatin resistance have been proposed from studies of cellular models of resistance including changes in cellular drug accumulation, detoxification of the drug, inhibition of apoptosis and repair of the DNA adducts.
Davey, Mary W., Stordal, Britta
core   +2 more sources

Assessment of low-dose cisplatin as a model of nausea and emesis in beagle dogs, potential for repeated administration [PDF]

, 2014
Cisplatin is a highly emetogenic cancer chemotherapy agent, which is often used to induce nausea and emesis in animal models. The cytotoxic properties of cisplatin also cause adverse events that negatively impact on animal welfare preventing repeated ...
A Tidholm, BD Rose, CC Horn, CL Limebeer, DC Dale, DM Vail, E Portillo, EM Rock, G Jang, GK Ogilvie, GK Ogilvie, GP Chrousos, GR Morrow, H Imamura, Hannah Kenward, IK Vonderen van, J Ito, J Loor, JD Chen, Jonathan Elliott, K Barabas, K Olsson, KL Koch, L Kelland, LA Parker, LA Parker, Ludovic Pelligand, LX Cubeddu, LX Cubeddu, M Boer-Dennert de, M Fredrikson, M Minami, MK Samson, MS Kim, N Percie du Sert, N Percie du Sert, PL Andrews, PL Andrews, PL Andrews, RD Fisher, S Ina, S Robery, SD Caras, T Bloom, V Napadow, VA Puente-Redondo de la, X Yu   +46 more
core   +3 more sources

Cisplatin liposome and 6-amino nicotinamide combination to overcome drug resistance in ovarian cancer cells [PDF]

, 2018
Ovarian cancer is an aggressive and lethal cancer usually treated by cytoreductive surgery followed by chemotherapy. Unfortunately, after an initial response, many patients relapse owing mainly to the development of resistance against the standard ...
Catanzaro, Daniela, Cocetta, Veronica, Montopoli, Monica, Nicolosi, Silvia, Pagetta, Andrea, Pasut, Gianfranco, Ragazzi, Eugenio, Salvalaio, Marika   +7 more
core   +1 more source

Oxaliplatin induces drug resistance more rapidly than cisplatin in H69 small cell lung cancer cells [PDF]

, 2006
Cisplatin produces good responses in solid tumours including small cell lung cancer (SCLC) but this is limited by the development of resistance. Oxaliplatin is reported to show activity against some cisplatin-resistant cancers but there is little known ...
A Ibrahim, A Rennicke, AB Sandler, AP Jekunen, BA Jansen, BA Teicher, Britta K. Stordal, BS Burns, C Kollmannsberger, C Kollmannsberger, CR Culy, D Pectasides, D Pectasides, DC Marks, G Belvedere, G Lenz, G Tisman, GA Hospers, H Kawai, H Kuroda, HD Preisler, HD Preisler, IS Song, J Liu, JM Woynarowski, JM Woynarowski, K Suzukake, K Yamamoto, KV Grech, L Pendyala, L Poulain, M Abal, M Markman, M Mishima, Mary W. Davey, N Jain, N Savaraj, N Thatcher, O Rixe, P Chollet, P Soulie, PJ Kuppen, PR Twentyman, R Sockalingam, RD Christen, Ross A. Davey, S Hector, S Ohta, SG Chaney, SL Lai, SW Johnson, T Fojo, T Moritaka, T Tashiro, V Dieras, VL Locke, WS Hong, Z El Akawi, Z Wang   +58 more
core   +2 more sources

Epigallocatechin-3-gallate, a prototypic chemopreventative agent for protection against cisplatin-based ototoxicity [PDF]

, 2017
Cisplatin-induced ototoxicity is one of the major factors limiting cisplatin chemotherapy. Ototoxicity results from damage to outer hair cells (OHCs) and other regions of the cochlea.
Bhatta, Puspanjali, Borse, Vikrant, Dhukhwa, Asmita, FH Al Aameri, Raheem, Ghosh, Sumana, Kaur, Tejbeer, Lowy, Michelle, Mukherjea, Debashree, Ramkumar, Vickram, Rybak, Leonard P, Sheehan, Kelly, Sheth, Sandeep, Tupal, Srinivasan   +12 more
core   +2 more sources

Glutamine protects against cisplatin-induced nephrotoxicity by decreasing cisplatin accumulation

Journal of Pharmacological Sciences, 2015
Cisplatin is a chemotherapeutic drug but induces acute kidney injury (AKI). Cisplatin-induced AKI depends on several signaling pathways leading to apoptosis in tubular epithelial cells.
Hyun-Jung Kim, Dong Jun Park, Jin Hyun Kim, Eun Young Jeong, Myeong Hee Jung, Tae-Ho Kim, Jung Ill Yang, Gyeong-Won Lee, Hye Jin Chung, Se-Ho Chang   +9 more
doaj   +1 more source

The endocannabinoid/cannabinoid receptor 2 system protects against cisplatin-induced hearing loss [PDF]

, 2018
Previous studies have demonstrated the presence of cannabinoid 2 receptor (CB2R) in the rat cochlea which was induced by cisplatin. In an organ of Corti-derived cell culture model, it was also shown that an agonist of the CB2R protected these cells ...
Asmita Dhukhwa, Debashree Mukherjea, Kelly Sheehan, Leonard P. Rybak, Leonard P. Rybak, Sandeep Sheth, Sumana Ghosh, Vickram Ramkumar, Vikrant Borse   +8 more
core   +4 more sources

Epigenetic and antitumor effects of platinum(IV)-octanoato conjugates [PDF]

, 2017
We present the anticancer properties of cis, cis, trans-[Pt(IV)(NH3)2Cl2(OA)2] [Pt(IV)diOA] (OA = octanoato), Pt(IV) derivative of cisplatin containing two OA units appended to the axial positions of a six-coordinate Pt(IV) center.
Brabec, Viktor, Gandin, Valentina, Gibson, Dan, Kasparkova, Jana, Marzano, Cristina, Novohradsky, Vojtech, Osella, Domenico, Pracharova, Jitka, Zanellato, Ilaria   +8 more
core   +1 more source

1-Hydroxy-8-methoxy-anthraquinon reverses cisplatin resistance by inhibiting 6PGD in cancer cells

Open Life Sciences, 2019
Targeting 6-phosphogluconate dehydrogenase (6PGD) can inhibit cancer cell proliferation and tumor growth. However, the relationship between 6PGD and cisplatin resistance still needs further study.
Zhang Huamin, Zhang Haowei, Wang Sihui, Ni Zhihai, Wang Tiejun   +4 more
doaj   +1 more source

Time-restricted feeding protects against cisplatin-induced acute kidney injury in mice [PDF]

Kidney Research and Clinical Practice
Background Time-restricted feeding (TRF), devoid of calorie restriction, is acknowledged for promoting metabolic health and mitigating various chronic metabolic diseases.
Kyu Won Jang, Young Suk Kim, Min Jeong Kim, Seo Rin Kim, Dong Won Lee, Soo Bong Lee, Il Young Kim   +6 more
doaj   +1 more source