Results 101 to 110 of about 2,487,415 (296)
Molecular mechanisms of cisplatin resistance in lung cancer
, 2013 Cisplatin is one of the most potent anticancer agents, displaying significant clinical activity against a variety of solid tumours. To date, cisplatin-based combination treatment remains the most effective systemic chemotherapy for non-small cell lung ...
O'Byrne, K., Barr, M.P.
core
Advanced Science, EarlyView.An engineered allosteric biosensor (UUU‐DZ‐tFNA) was developed, in which UDG specifically recognizes and activates a DNAzyme to achieve signal cycle amplification in a sequentially activatable mode. UUU‐DZ‐tFNA achieves in situ UDG detection across multiple biological levels and facilitates risk stratification and drug resistance monitoring of NB ...
Yaqing Lu +10 more
wiley +1 more source
Cancer Management and Research, 2020 Mingzhe Zhu,1,* Lei Yang,2,* Xin Wang3 1Department of Obstetrics and Gynecology, Jilin Medical College Affiliated Hospital, Jilin City, Jilin Province 132011, People’s Republic of China; 2Department of Medical Clinic, Yuhuangding Hospital, Yantai ...
Zhu M, Yang L, Wang X
doaj
一系列對cisplatin具不等程度抗藥性之移型上皮癌細胞株的抗藥性機轉研究
, 2009 We explored the mechanisms of cisplatin resistance in a series of bladder transitional carcinoma cells that are either sensitive or progressively resistant to cisplatin.
侯自銓;陳淳;黃昭淵;官靜儀;呂秀慧;謝長堯;蒲永孝 +1 more
core
Advanced Science, EarlyView.This Review outlines the biological framework of entry, maintenance, and awakening in dormant minimal residual disease across gynecologic cancers. By mapping critical biological dependencies—from metabolic plasticity to microenvironment interactions—it evaluates novel interception concepts and presents a translational framework combining single‐cell ...
Shih‐Hsuan Cheng +7 more
wiley +1 more source
Advanced Science, EarlyView.This study reveals that 5'tiRNA‐Gln interacts with hnRNPC to promote IGF1R liquid‐liquid phase separation, which drives ERK1/2 signaling activation, EMT, and breast cancer bone metastasis. These findings highlight a novel mechanism of breast cancer bone metastasis and potential therapeutic target in metastatic breast cancer.
Bingnan Wang +9 more
wiley +1 more source
Identifying intracellular cisplatin interaction partners and assessing their contribution to cisplatin resistance [PDF]
, 2016 Intracellular binding of cisplatin to non-DNA partners, such as proteins, has received increasing attention as an additional mode of action as well as a mechanism of resistance.
Kullmann, Maximilian
core +1 more source
Background: Cancer cells can alter glucose metabolism and regulate the expression of glucose transporters. Hepatoblastoma patients undergo cisplatin-based chemotherapy; however, 22.3% of patients develop cisplatin resistance and thus face a poor ...
Kondo, Takafumi +5 more
core +1 more source
Advanced Science, EarlyView.This study establishes a novel cisplatin‐induced rat model of PAH/PVOD and identifies a conserved mechanistic axis—FANCL impairment, DNA damage accumulation, and endothelial dysfunction—triggered by cisplatin or mitomycin C across pulmonary arteries, veins, and microvessels.
Shiyun Liu +20 more
wiley +1 more source
Role of Autophagy in Cisplatin Resistance of Retinoblastoma Y79 Cells and Its Mechanism
Zhongliu Fangzhi Yanjiu, 2018 Objective To investigate the role of autophagy in cisplatin resistance of retinoblastoma Y79 cells and its mechanism. Methods The IC50 of cells was detected by CCK-8 assay. Y79 cells were randomly divided into control group, Cisplatin group and cisplatin
LIU Ying, SU Jie, WANG Linhong
doaj +1 more source