Results 91 to 100 of about 112,964 (206)

Study on mechanism of action of β-elemene in inhibiting cisplatin resistance in lung cancer through LncRNA LINC00511

Frontiers in Pharmacology
BackgroundLung cancer is a leading cause of cancer-related deaths, with cisplatin being a cornerstone of treatment. However, resistance to cisplatin presents a significant challenge.
Xiaoli Deng, Chunjie Hu, Lin Li, Guixian Yang, Chikun Li, Wanxun Zhang, Guangyu Cheng   +6 more
doaj   +1 more source

Investigation of the role of LRP in multidrug resistance [PDF]

, 1998
There have been many reports linking the overexpression of the lung resistance-related protein (LRP) with cross-resistance to chemotherapeutic drugs.
Byrne, Daragh
core  

Blocking Oncostatin M receptor abrogates STAT3 mediated integrin signaling and overcomes chemoresistance in ovarian cancer

npj Precision Oncology
Chemotherapy such as cisplatin is widely used to treat ovarian cancer either before or after surgical debulking. However, cancer relapse due to chemotherapy resistance is a major challenge in the treatment of ovarian cancer.
Anjali Geethadevi, Zhiqiang Ku, Shirng-Wern Tsaih, Deepak Parashar, Ishaque P. Kadamberi, Wei Xiong, Hui Deng, Jasmine George, Sudhir Kumar, Sonam Mittal, Ningyan Zhang, Sunila Pradeep, Zhiqiang An, Pradeep Chaluvally-Raghavan   +13 more
doaj   +1 more source

Generation of Cisplatin-Resistant Ovarian Cancer Cell Lines: Cisplatin Resistance in Ovarian Cancer Cell Lines

, 2016
Ovarian cancer is the most lethal gynecological cancer in which cisplatin-based treatment plays a fundamental role as the first line chemotherapy option.
Nastaran Nikounezhad, Farshad H. Shirazi, Maryam Nakhjavani   +2 more
core   +1 more source

Acquisition of Cisplatin-resistance in Malignant Mesothelioma Cells Abrogates Na,K(+),2Cl(-;)-cotransport Activity and Cisplatin-induced Early Membrane Blebbing

, 2008
AIMS: Resistance mechanisms are important limiting factors in the treatment of solid malignancies with cis-diamminedichloroplatinum(II) (cisplatin).
Behnam-Motlagh, Parviz,, Grankvist, Kjell,, Henriksson, Roger,, Janson, Veronica,, Andersson, Britta,, Engström, Karl-Gunnar,   +5 more
core   +1 more source

SH3RF2 contributes to cisplatin resistance in ovarian cancer cells by promoting RBPMS degradation

Communications Biology
Platinum-based chemotherapy remains one of the major choices for treatment of ovarian cancer (OC). However, primary or acquired drug resistance severely impairs their efficiency, thereby causing chemotherapy failure and poor prognosis.
Ting-Ting Gong, Fang-Hua Liu, Qian Xiao, Yi-Zi Li, Yi-Fan Wei, He-Li Xu, Fan Cao, Ming-Li Sun, Feng-Li Jiang, Tao Tao, Qi-Peng Ma, Xue Qin, Yang Song, Song Gao, Lang Wu, Yu-Hong Zhao, Dong-Hui Huang, Qi-Jun Wu   +17 more
doaj   +1 more source

Studies of protein post-translational modifications using high resolution tandem mass spectrometry [PDF]

Electron capture dissociation (ECD) is a powerful and superior tandem mass spectrometry (MS) fragmentation technique in the study of protein post-translational modifications (PTMs) due to its unique features of preserving labile modifications and ...
Li, Huilin
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MKP-1 suppresses PARP-1 degradation to mediate cisplatin resistance

, 2018
Understanding the mechanisms of platinum compound resistance, including cisplatin resistance, has important implications for improving cancer treatments. Previous studies identified a potential role for mitogen-activated protein kinase phosphatase-1 (MKP-
Davis, Roger J, Kho, Dhonghyo, Wu, Gen Sheng, Wang, Juan, Zhou, Jun-Ying   +4 more
core   +1 more source

MiR-21-5p Modulates Cisplatin-Resistance of CD44+ Gastric Cancer Stem Cells Through Regulating the TGF-β2/SMAD Signaling Pathway

Xinyang Nie,1– 3,* Jian Liu,1,2,* Daohan Wang,1,2,* Chuan Li,1,2 Yuxin Teng,1,2 Zhufeng Li,1,2 Yangpu Jia,1,2 Peiyao Wang,1,2 Jingyu Deng,2,3 Weidong Li,1,2 Li Lu1,2 1Department of General Surgery, Tianjin Medical University General Hospital,
Li W, Lu L, Liu J, Li Z, Wang P, Li C, Wang D, Jia Y, Deng J, Teng Y, Nie X   +10 more
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Cisplatin induces protective autophagy through activation of BECN1 in human bladder cancer cells

, 2017
Ji-Fan Lin,1 Yi-Chia Lin,2 Te-Fu Tsai,2,3 Hung-En Chen,2 Kuang-Yu Chou,2,3 Thomas I-Sheng Hwang2–4 1Central Laboratory, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, 2Division of Urology, School of Medicine, Fu-Jen Catholic University, New Taipei,
Lin JF, Lin YC, Tsai TF, Chen HE, Chou KY, Hwang TIS   +5 more
core