Results 71 to 80 of about 112,964 (206)
Cisplatin resistance and opportunities for precision medicine
Pharmacological Research, 2016 Cisplatin is one of the most commonly used chemotherapy drugs, treating a wide range of cancer types. Unfortunately, many cancers initially respond to platinum treatment but when the tumor returns, drug resistance frequently occurs. Resistance to cisplatin is attributed to three molecular mechanisms: increased DNA repair, altered cellular accumulation,
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New precious metal compounds in cancer therapy
, 2008 Includes abstract.Includes bibliographical references (leaves 139-160).Cisplatin is one of the most effective cancer medications currently available. However, it is seriously limited by patient toxicity and drug resistance.
Peters, Dean Douglas
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, 2016 Platinum−acridine conjugates were prepared from [PtCl2(ethane-1,2-diamine)] and the novel acridinylthioureas MeHNC(S)NMeAcr (6) and MeHNC(S)NMe(CH2CH2)NHAcr (15) by replacing one chloro leaving group in the cisplatin analogue with thiourea sulfur.
Elizabeth T. Martins (3012990) +6 more
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CDKN3 promotes tumor progression and confers cisplatin resistance via RAD51 in esophageal cancer
, 2019 Jiansong Wang,1 Wencheng Che,2 Weimin Wang,1 Gongzhang Su,3 Tianchang Zhen,3 Zhongmin Jiang31Graduate Department, Weifang Medical University, Weifang, Shandong 261031, People’s Republic of China; 2Department of Thoracic Surgery, Zibo Central ...
Jiang Z +5 more
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Molecular mechanisms of cisplatin resistance in lung cancer
, 2013 Cisplatin is one of the most potent anticancer agents, displaying significant clinical activity against a variety of solid tumours. To date, cisplatin-based combination treatment remains the most effective systemic chemotherapy for non-small cell lung ...
O'Byrne, K., Barr, M.P.
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Role of Autophagy in Cisplatin Resistance of Retinoblastoma Y79 Cells and Its Mechanism
Zhongliu Fangzhi Yanjiu, 2018 Objective To investigate the role of autophagy in cisplatin resistance of retinoblastoma Y79 cells and its mechanism. Methods The IC50 of cells was detected by CCK-8 assay. Y79 cells were randomly divided into control group, Cisplatin group and cisplatin
LIU Ying, SU Jie, WANG Linhong
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一系列對cisplatin具不等程度抗藥性之移型上皮癌細胞株的抗藥性機轉研究
, 2009 We explored the mechanisms of cisplatin resistance in a series of bladder transitional carcinoma cells that are either sensitive or progressively resistant to cisplatin.
侯自銓;陳淳;黃昭淵;官靜儀;呂秀慧;謝長堯;蒲永孝 +1 more
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MECHANISM OF APOPTOSIS INHIBITION TO SQUAMOUS CELL CARCINOMA OF ORAL CANCER IN CISPLATIN TREATMENT
Folia Medica Indonesiana, 2017 This study was to approve the increased secretion of Hsp 70, DNA damage, and inhibitor apoptosis protein in cisplatin therapy which influence apoptosis of oral cancer cell and to know mechanism of molecular pathology.
R Marjono Dwi Wibowo +2 more
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miR-133b reverses cisplatin resistance by targeting GSTP1 in cisplatin-resistant lung cancer cells
International Journal of Molecular Medicine, 2018 MicroRNAs play a critical role in chemoresistance and are implicated in various biological and pathological processes of cells. The objective of the present study was to explore the role of miR‑133b and its mechanism in the regulation of cisplatin resistance and tumor progression in cisplatin‑resistant non‑small cell lung cancer (NSCLC) cells.
Lin, Chen +4 more
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The Role of Epigenetics in Resistance to Cisplatin Chemotherapy in Lung Cancer
, 2011 Non-small cell lung cancer (NSCLC) is the most common cause of cancer related death in the world. Cisplatin and carboplatin are the most commonly used cytotoxic chemotherapeutic agents to treat the disease.
O\u27BYRNE, KEN +8 more
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