Results 81 to 90 of about 112,964 (206)

Mass spectrometry-based proteomic analysis to characterize cisplatin induced early signaling events in head and neck squamous cell carcinoma

Molecular & Cellular Oncology
Cisplatin is the commonly used chemotherapeutic drug in treatment of various cancers. However, development of resistance towards cisplatin results in tumor recurrence.
Ankit P. Jain, Vivek Ghose, Srijon Munshi, Firdous A. Bhat, Gourav Dey, Vishalakshi Nanjappa   +5 more
doaj   +1 more source

Knockdown of TOP2A reverses cisplatin resistance in ovarian cancer by inhibiting EMT via ferroptosis mediated by the TP53/GPX4/SLC7A11 axis

Frontiers in Immunology
IntroductionCisplatin resistance is a major challenge in ovarian cancer therapy, particularly for high-grade serous ovarian cancer (HGSOC). DNA topoisomerase IIα (TOP2A) relates to cancer drug resistance, yet its role and molecular mechanisms in ovarian ...
Xinyue Liu, Xinyue Liu, Junxia Wang, Yangyu Liu, Yan Han, Zhichao Qin, Yu Wang, Shanxiang Gao, Xinghua Li, Yuping Suo   +9 more
doaj   +1 more source

SGLT2 is upregulated to acquire cisplatin resistance and SGLT2 inhibition reduces cisplatin resistance in hepatoblastoma

Background: Cancer cells can alter glucose metabolism and regulate the expression of glucose transporters. Hepatoblastoma patients undergo cisplatin-based chemotherapy; however, 22.3% of patients develop cisplatin resistance and thus face a poor ...
Kondo, Takafumi, Honda, Shohei, Kobayashi, Nozomi, Fujiyoshi, Sunao, Taketomi, Akinobu, Ara, Momoko   +5 more
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Evaluating the efficacy of DNA repair biomarkers to assess human cell response to chemotherapy using imaging flow cytometry [PDF]

, 2013
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Chemotherapy and radiotherapy are widely accepted as common forms of treatment for cancers. The majority of cancer patients receive chemotherapy alone or in
Zahir, Sheba Adam
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CRISPR-Cas9 screening identifies ATOX1-driven cisplatin resistance mechanisms in liver cancer and evaluates targeted inhibitor efficacy

Communications Biology
Liver cancer treatment with cisplatin is often hindered by drug resistance. This study aimed to identify key genes associated with cisplatin resistance in liver cancer and develop targeted inhibitors.
Chujiao Hu, Huading Tai, Renguang Zhu, Zhengyu Shu, Guanghao Guo, Dan Ma, Shi Zuo, Lei Tang, Zhirui Zeng   +8 more
doaj   +1 more source

Cytotoxicity and resistance mechanisms of cisplatin

, 2021
In recent years, cisplatin has found wide application in different types of cancer. Among the different platinum compounds, cisplatin was found to be able to cross the cell membrane due to its simple chemical structure and, form adducts with DNA, to ...
Ruggiero A., Mastrangelo S.
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Targeting ferroptosis as a potential strategy to overcome the resistance of cisplatin in oral squamous cell carcinoma

Frontiers in Pharmacology
Oral squamous cell carcinoma (OSCC) is a crucial public health problem, accounting for approximately 2% of all cancers globally and 90% of oral malignancies over the world.
Rongkun Chen, Rongkun Chen, Shuyu Zhu, Ruoyu Zhao, Ruoyu Zhao, Wang Liu, Wang Liu, Luxin Jin, Luxin Jin, Xiaobin Ren, Xiaobin Ren, Hongbing He   +11 more
doaj   +1 more source

SRC enhanced cisplatin resistance in bladder cancer by reprogramming glycolysis and pentose phosphate pathway

Communications Biology
The development of cisplatin resistance often results in a grim prognosis in advanced or recurrent bladder cancer. However, effective treatment strategies for cisplatin resistance have not been well established.
Yuwen Gong, Dongyang Gao, Yibo Shi, Guangrui Fan, Xiaoquan Yu, Enguang Yang, Hui Cheng, Junqiang Tian, Hui Ding, Shanhui Liu, Shengjun Fu, Yan Tao, Yuan Shui, Liang Cheng, Lanlan Li, Zhiping Wang   +15 more
doaj   +1 more source

Molecular mechanisms of cisplatin resistance in ovarian cancer

Genes and Diseases
Ovarian cancer is one of the most common malignant tumors of the female reproductive system. The majority of patients with advanced ovarian cancer are mainly treated with cisplatin-based chemotherapy.
Chenying Jiang, Chenjun Shen, Maowei Ni, Lili Huang, Hongtao Hu, Qinhui Dai, Huajun Zhao, Zhihui Zhu   +7 more
doaj   +1 more source

Nuclear EGFR modulation of DNA repair

, 2011
Overexpression of the epidermal growth factor receptor (EGFR) is associated with resistance to chemotherapy and radiotherapy. EGFR involvement, in repair of radiation-induced DNA damage, is mediated by association with the catalytic subunit of DNA ...
Liccardi, G.
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