Results 61 to 70 of about 112,964 (206)

Inhibition of 6-phosphogluconate Dehydrogenase Reverses Cisplatin Resistance in Ovarian and Lung Cancer

Frontiers in Pharmacology, 2017
Cisplatin (DDP) is currently one of the most commonly used chemotherapeutic drugs for treating ovarian and lung cancer. However, resistance to cisplatin is common and it often leads to therapy failure.
Wujian Zheng, Qi Feng, Jiao Liu, Yanke Guo, Lvfen Gao, Ruiman Li, Meng Xu, Guizhen Yan, Zhinan Yin, Shuai Zhang, Shuangping Liu, Changliang Shan   +11 more
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Active Efflux System for Cisplatin in Cisplatin‐resistant Human KB Cells [PDF]

Japanese Journal of Cancer Research, 1994
Mutants, KCP‐4 and PC‐5, resistant to an anticancer agent, cisplatin, were selected in multiple steps from human epidermoid KB carcinoma cells and human prostate PC‐3 carcinoma cells, respectively. KCP‐4 and PC‐5 were 63 and 10 fold more resistant to cisplatin than the parental cells, respectively.
Fujii, Ryu‐ichi, Mutoh, Masato, Niwa, Kiyoshi, Yamada, Kazutaka, Aikou, Takashi, Nakagawa, Masayuki, Kuwano, Michihiko, Akiyama, Shin‐ichi   +7 more
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Inflammatory meditated mechanisms of cisplatin resistance in non-small cell lung cancer

, 2016
Free to read on publisher's website\ud \ud The majority of non-small cell lung cancer (NSCLC) patients present with advanced stage disease, where chemotherapy is usually the most common treatment option.
Gray, S.G., O'Byrne, K., Davies, A., Heavey, S., Barr, M.P., Baird, A.-M., Umezawa, K., Richard, D., Gately, K., Ryan, S-L   +9 more
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Unusual DNA binding modes for metal anticancer complexes [PDF]

, 2009
DNA is believed to be the primary target for many metal-based drugs. For example, platinum-based anticancer drugs can form specific lesions on DNA that induce apoptosis.
Pizarro, Ana M., Sadler, P. J.
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New extracellular resistance mechanism for cisplatin

Journal of Inorganic Biochemistry, 2008
The HSQC NMR spectrum of 15N-cisplatin in cell growth media shows resonances corresponding to the monocarbonato complex, cis-[Pt(NH3)2(CO3)Cl](-), 4, and the dicarbonato complex, cis-[Pt(NH3)2(CO3)2](-2), 5, in addition to cisplatin itself, cis-[Pt(NH3)2Cl2], 1. The presence of Jurkat cells reduces the amount of detectable carbonato species by (2.8+/-0.
Centerwall, Corey R, Kerwood, Deborah J, Goodisman, Jerry, Toms, Bonnie B, Dabrowiak, James C   +4 more
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Single-cell transcriptome analysis reveals the association between histone lactylation and cisplatin resistance in bladder cancer

Patients with bladder cancer (BCa) frequently acquires resistance to platinum-based chemotherapy, particularly cisplatin. This study centered on the mechanism of cisplatin resistance in BCa and highlighted the pivotal role of lactylation in driving this ...
Chen, Shijun, Cao, Chun, Huang, Zehai, Hou, Lina, Tan, Wanlong, Xie, Kunfeng, Fan, Qin, Zhang, Henghui, Chen, Haiyong, Zheng, Zaosong, Deng, Fan, Li, Dongqing, Wang, Qiong, Li, Fei, Huang, Yuan, Zhao, Xinlei, Deng, Xiaolin   +16 more
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Lactate promoted cisplatin resistance in NSCLC by modulating the m6A modification-mediated FOXO3/MAGI1-IT1/miR-664b-3p/IL-6R axis

Neoplasia: An International Journal for Oncology Research
Background: Cisplatin resistance is one of the major obstacles in non-small cell lung cancer (NSCLC) treatment. Intriguingly, elevated lactate levels were observed in cisplatin-resistant cells, which spurred further investigation into their underlying ...
Wei Bo, Ning Yu, Xiaokai Wang, Chun Wang, Chunying Liu   +4 more
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Putative cancer stem cells in malignant pleural mesothelioma show resistance to cisplatin and pemetrexed

, 2010
Malignant pleural mesothelioma (MPM) is a lethal cancer of the mesothelium with high chemotherapeutic resistance via unknown mechanisms. A prevailing hypothesis states that cancer stem cells (CSCs) persist in tumors causing relapse after chemotherapy ...
Carboni, Giovanni L, Karoubi, Golnaz, Schmid, Ralph A, Cortes-Dericks, Lourdes   +3 more
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Autophagy facilitates lung adenocarcinoma resistance to cisplatin treatment by activation of AMPK/mTOR signaling pathway

, 2015
Tao Wu,1 Min-Cong Wang,1 Li Jing,1 Zhi-Yan Liu,2 Hui Guo,1 Ying Liu,3 Yi-Yang Bai,1 Yang-Zi Cheng,1 Ke-Jun Nan,1 Xuan Liang1 1Department of Medical Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, 2Department of Respiratory ...
Bai YY, Liu Y, Wang MC, Jing L, Cheng YZ, Liang X, Guo H, Nan KJ, Liu ZY, Wu T   +9 more
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NEAT1 Knockdown Suppresses the Cisplatin Resistance in Ovarian Cancer by Regulating miR-770-5p/PARP1 Axis

Cancer Management and Research, 2020
Mingzhe Zhu,1,* Lei Yang,2,* Xin Wang3 1Department of Obstetrics and Gynecology, Jilin Medical College Affiliated Hospital, Jilin City, Jilin Province 132011, People’s Republic of China; 2Department of Medical Clinic, Yuhuangding Hospital, Yantai ...
Zhu M, Yang L, Wang X
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