Results 151 to 160 of about 112,964 (206)

Targeting the ANGPTL4/NRP1/ABL1/RAD51 axis reverses cisplatin resistance by impairing DNA damage repair in head and neck cancer. [PDF]

Proc Natl Acad Sci U S A
Asiedu EB, Kumar A, Choi A, Luciano DO, Lo K, Sharma D, Ma T, Rassool F, Sodhi A, Montaner S.   +9 more
europepmc   +1 more source

Targeting ANXA4 to Overcome Cisplatin Resistance in Ovarian Cancer: A Bioinformatics and in Vitro Study. [PDF]

Onco Targets Ther
Wang Y, Xie Q.
europepmc   +1 more source

Biowaste-Archetyped Hierarchical Calcium Carbonate Nanoreactors Induce Tumor Bioenergetic Crisis and Reverse Cisplatin Resistance via Mitochondrial Metabolic Reprogramming. [PDF]

ACS Appl Mater Interfaces
Shi S, Liu H, Peng Q, Nan S, Liu S, Wei L, Wang H, Wang K, Zhong X, Chen X, Gao W.   +10 more
europepmc   +1 more source

Metformin suppressed epithelial-mesenchymal transition, cisplatin resistance and metastatic potential of ovarian cancer via inhibiting TGF-β1/Smads. [PDF]

Transl Cancer Res
Tang H, Han Z, Zhu W, Lin X, Chen J, Li J, He X, Chen M, Yang Y, Yang Z, Li F, Wang J, Meng X, Zhang K.   +13 more
europepmc   +1 more source

Integrated Analyses Identify <i>CDH2</i> as a Hub Gene Associated with Cisplatin Resistance and Prognosis in Ovarian Cancer. [PDF]

Int J Mol Sci
Xu JY, Tian MQ, Yang R, Li ZX, Lin ZH, Wang YF, Chu YH, Sun WN, Wang YM.   +8 more
europepmc   +1 more source

Tumour resistance to cisplatin: a modelling approach

Physics in Medicine and Biology, 2004
Although chemotherapy has revolutionized the treatment of haematological tumours, in many common solid tumours the success has been limited. Some of the reasons for the limitations are: the timing of drug delivery, resistance to the drug, repopulation between cycles of chemotherapy and the lack of complete understanding of the pharmacokinetics and ...
Marcu, L., Bezak, E., Olver, I., Van Doorn, T.   +3 more
openaire   +4 more sources

Molecular mechanisms of cisplatin resistance in cervical cancer

Drug Design, Development and Therapy, 2016
Haiyan Zhu, Hui Luo, Wenwen Zhang, Zhaojun Shen, Xiaoli Hu, Xueqiong Zhu Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China Abstract: Patients with advanced ...
Xueqiong Zhu, Haiyan Zhu, Wenwen Zhang   +2 more
exaly   +1 more source

Cellular landscaping of cisplatin resistance in cervical cancer [PDF]

Biomedicine and Pharmacotherapy, 2022
Publisher Copyright: © 2022 The AuthorsCervical cancer (CC) caused by human papillomavirus (HPV) is one of the largest causes of malignancies in women worldwide.
Mimosa Ghorai, Niraj Kumar Jha, JOSÉ M Pérez De La Lastra   +2 more
exaly   +2 more sources

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Mechanisms of resistance to cisplatin

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2001
The use of cisplatin in cancer chemotherapy is limited by acquired or intrinsic resistance of cells to the drug. Cisplatin enters the cells and its chloride ligands are replaced by water, forming aquated species that react with nucleophilic sites in cellular macromolecules.
M, Kartalou, J M, Essigmann
openaire   +2 more sources

Cisplatin Resistance and Transcription Factors

Current Medicinal Chemistry-Anti-Cancer Agents, 2005
Cisplatin is one of the most potent and widely used anti-cancer agents in the treatment of various solid tumors. However, the development of resistance to cisplatin is a major obstacle in clinical treatment. Several mechanisms are thought to be involved in cisplatin resistance, including decreased intracellular drug accumulation, increased levels of ...
Takayuki, Torigoe, Hiroto, Izumi, Hiroshi, Ishiguchi, Yoichiro, Yoshida, Mizuho, Tanabe, Takeshi, Yoshida, Tomonori, Igarashi, Ichiro, Niina, Tetsuro, Wakasugi, Takuya, Imaizumi, Yasutomo, Momii, Michihiko, Kuwano, Kimitoshi, Kohno   +12 more
openaire   +2 more sources