Results 131 to 140 of about 166,355 (310)

High Stability of Diketopyrrolopyrrole Polymer Transistors Under Aqueous Condition Toward Biosensing Platform

Advanced Materials Technologies, EarlyView.
We are reporting the first‐time investigation of DPP‐based Organic Field‐Effect Transistor (OFET) devices with high‐stability of signal response in both of ambient and aqueous conditions with PBS solution. ABSTRACT Diketopyrrolopyrrole (DPP)–based conjugated polymers show strong promise for electronic applications, including bioelectronic gas sensors ...
Chattarika Khamhanglit, Yudai Hemmi, Ami Ichikawa, YuanTong Gu, Kuniaki Nagamine, Hiroyuki Matsui, Prashant Sonar   +6 more
wiley   +1 more source

Anti-tubulin drugs conjugated to anti-ErbB antibodies selectively radiosensitize. [PDF]

, 2016
Tumour resistance to radiotherapy remains a barrier to improving cancer patient outcomes. To overcome radioresistance, certain drugs have been found to sensitize cells to ionizing radiation (IR).
Adams, Stephen R, Advani, Sunil J, Aguilera, Joe, Cohen, Ezra EW, Crisp, Jessica L, Jones, Karra A, Lippman, Scott M, Savariar, Elamprakash N, Tsien, Roger Y, Whitney, Michael A, Yang, Howard C   +10 more
core   +1 more source

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

Role of Autophagy in Cisplatin Resistance of Retinoblastoma Y79 Cells and Its Mechanism

Zhongliu Fangzhi Yanjiu, 2018
Objective To investigate the role of autophagy in cisplatin resistance of retinoblastoma Y79 cells and its mechanism. Methods The IC50 of cells was detected by CCK-8 assay. Y79 cells were randomly divided into control group, Cisplatin group and cisplatin
LIU Ying, SU Jie, WANG Linhong
doaj   +1 more source

Original Multivalent Gold (III) and Dual Gold(III)-Copper(II) Conjugated Phosphorus Dendrimers as Potent Antitumoral and Antimicrobial Agents [PDF]

, 2017
Original metallophosphorus dendrimers (generation 3, 48 terminal groups) have been prepared via the complexation of phosphorus dendrimers bearing imino-pyridino end groups with Au(III) or with both Au(III) and Cu(II).
Serge M. Mignani, Nabil El Brahmi, Saïd El Kazzouli, Regis Laurent, Sonia Ladeira, Anne-Marie Caminade, Elzbieta Pedziwiatr-Werbicka, Eligia M. Szewcyk, Maria Bryszewska, Mosto M. Bousmina, Thierry Cresteil, Jean Pierre Majoral   +11 more
core   +2 more sources

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Use of top-down and bottom-up fourier transform ion cyclotron resonance mass spectrometry for mapping calmodulin sites modified by platinum anticancer drugs [PDF]

, 2011
Calmodulin (CaM) is a highly conserved, ubiquitous, calcium-binding protein; it binds to and regulates many different protein targets, thereby functioning as a calcium sensor and signal transducer.
Barrow, Mark P., Li, Huilin, Lin, Tzu-Yung, O’Connor, Peter B., Pizarro, Ana M., Qi, Yulin, Sadler, P. J., Van Orden, Steve L., Zhao, Yao, (Researcher in chemistry)   +8 more
core   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

Mass spectrometry-based proteomic analysis to characterize cisplatin induced early signaling events in head and neck squamous cell carcinoma

Molecular & Cellular Oncology
Cisplatin is the commonly used chemotherapeutic drug in treatment of various cancers. However, development of resistance towards cisplatin results in tumor recurrence.
Ankit P. Jain, Vivek Ghose, Srijon Munshi, Firdous A. Bhat, Gourav Dey, Vishalakshi Nanjappa   +5 more
doaj   +1 more source

Reduced expression of bax in small cell lung cancer cells is not sufficient to induce cisplatin-resistance

European Journal of Medical Research, 2010
Resistance to cisplatin in the course of chemotherapy contributes to the poor prognosis of small cell lung cancer (SCLC). B cell lymphoma-2 is the founding member of a large family of proteins that either promote or inhibit apoptosis.
Biagosch J, Huber RM, Bergner A
doaj   +1 more source