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Mechanisms of resistance to cisplatin and alkylating agents
1989All too often, human solid tumors follow a pattern of initial sensitivity to chemotherapy manifested by a decrease of tumor burden followed by a loss of sensitivity to chemotherapy and by tumor regrowth [1]. This sequence of events is attributed to the presence of a subset of cells in the original tumor that are resistant at the onset of therapy and/or
T C, Hamilton +5 more
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Cross-resistance to cisplatin in cells with acquired resistance to copper
Cancer Chemotherapy and Pharmacology, 2004Cells selected for resistance to cisplatin (DDP) demonstrate cross-resistance to copper (Cu) suggesting one or more common mechanisms of cellular defense. We sought to determine whether cells selected for resistance to Cu are cross-resistant to DDP.Parental HuH7 human hepatoma cells and the CuR27 Cu-resistant subline were compared for sensitivity to Cu
Roohangiz, Safaei +6 more
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Metallothioneins and Cisplatin Resistance
1991Intrinsic and acquired resistance to antineoplastic agents has severely limited our ability to cure solid tumors. Cis-diamminedichloroplatinum (cisplatin) represents one of the most efficacious agents for the treatment of solid tumors especially testicular, ovarian, bladder, and head and neck carcinomas.
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Biochemical and Molecular Mechanisms of Cisplatin Resistance
2002According to the DISCOVERY Anticancer Drug Screen of the National Cancer Institute in the USA, the inorganic antitumor agent cisplatin(cisdiammine-dichloro-platinum(II); Figure 1) and its analogs fall into at least 13 clustered regions, each reflecting a distinct mechanism of action1. Many of these analogs have not been investigated in depth to unravel
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Cisplatin resistance reversal with treatment of Citric acid in cisplatin-resistant cell lines
ABSTRACT Gastric cancer (GC) is a prevalent and aggressive malignancy with significant morbidity and mortality rates, posing a major threat to human health globally. While surgery remains the preferred clinical treatment, chemotherapy continues to be the cornerstone for perioperative care, adjuvant therapy, and palliative treatment for ...Siddhant Chaturvedi, Krishna Venka
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Antibiotic Resistance in the Patient With Cancer: Escalating Challenges and Paths Forward
Ca-A Cancer Journal for Clinicians, 2021Amila K Nanayakkara, David E Greenberg
exaly
Cisplatin resistance and DNA repair
Cancer Treatment Reviews, 1997Crul, M. +3 more
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