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Effects of citicoline on experimental spinal cord injury
Journal of Clinical Neuroscience, 2005 Objective: To investigate the effects of citicoline on experimental spinal cord injury (SCI). Background Citicoline has been successfully used in clinical studies of head injury and cerebral infarction, but there is limited literature regarding its Use ...
Murat Topbaş, Ahmet Alver, Tayfun Cakir
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Experimental Eye Research, 2021 It has been reported that citicoline increases antioxidant activity in some tissues. However, the effect of citicoline on corneal wound-healing has not yet been demonstrated.
Ahmet Öztürk +2 more
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An Overview of Combination Treatment with Citicoline in Dementia
Reviews on Recent Clinical Trials, 2022Introduction: The present article reports an overview of the studies about combination treatment with citicoline of Alzheimer’s (AD) and mixed dementia (MD). Methods: A Medline search was carried out by using the keywords Alzheimer’s dementia, mixed dementia, older people, treatment with citicoline, memantine, and acetylcholinesterase inhibitors ...
Pietro Gareri +2 more
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Citicoline in addictive disorders: a review of the literature [PDF]
American Journal of Drug and Alcohol Abuse, 2014 Citicoline is a dietary supplement that has been used as a neuroprotective agent for neurological disorders such as stroke and dementia. Citicoline influences acetylcholine, dopamine, and glutamate neurotransmitter systems; serves as an intermediate in phospholipid metabolism; and enhances the integrity of neuronal membranes.
Sherwood Brown
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Membrane Stabilizer: Citicoline
Current Medical Research and Opinion, 2002Brain ischaemia leads to a cascade of biochemical events, many of which ultimately cause cell membrane injury. Therefore, measures aimed at protecting neuronal membranes could be useful treatment strategies following stroke. Citicoline (cytidine-5-diphosphocholine; CDP-choline) is a naturally occurring nucleotide derivative that may reduce central ...
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Citicoline Improves Verbal Memory in Aging
Archives of Neurology, 1996To test the verbal memory of older volunteers given citicoline.A randomized, double-blind, placebo-controlled, parallel group design was employed in the initial study. After data analysis, a subgroup was identified whose members had relatively inefficient memories. These subjects were recruited for a second study that used a crossover design.
P A, Spiers +4 more
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Pharmacodynamics of citicoline relevant to the treatment of glaucoma
Journal of Neuroscience Research, 2001AbstractCiticoline (exogenous CDP‐choline) is a nontoxic and well‐tolerated drug used in pharmacotherapy of brain insufficiency and some other neurological disorders, such as stroke, brain trauma, and Parkinson's disease. A few reports indicate that citicoline treatment may also be beneficial in glaucoma.
Pawel, Grieb, Robert, Rejdak
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Efficacy of citicoline as an acute stroke treatment
Expert Opinion on Pharmacotherapy, 2009Citicoline (cytidine-5'-diphosphocholine or CDP-choline) is a precursor essential for the synthesis of phosphatidylcholine, one of the cell membrane components that is degraded during cerebral ischemia to free fatty acids and free radicals. Animal studies suggest that citicoline may protect cell membranes by accelerating resynthesis of phospholipids ...
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