Results 31 to 40 of about 2,932,973 (293)
, 2013 Towns and cities existed throughout Africa’s past. However since the late twentieth century Africans are witnessing a historically unprecedented transition from living mainly in rural areas to residing in cities.
Meier Zu Selhausen, Felix
core
City Festivals and Festival Cities [PDF]
, 2020 This chapter discusses the role of city festivals in shaping and re-imagining urban space. There has been increased interest in festivals among decision-makers and marketers as vehicles for cultural profiling, regeneration, and social inclusion. The chapter views space as inseparable from economic and social structures and practices which govern urban ...
openaire +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
From Smart Cities To Playable Cities. Towards Playful Intelligence In The Urban Environment [PDF]
, 2018 In the last decade, we have seen the rise of urban play as a tool for community building, and city-making and Western society is actively focusing on play/playfulness and intelligent systems as a way to approach complex challenges and emergent situations.
Perna, Valerio
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Collective Impact Partnerships: The Data to Action Hourglass Model
Interdisciplinary Journal of Partnership Studies, 2022 Models are needed to guide positive health care and social transformation using real-world data, particularly in an era of data-driven science and accountability.
Karen Monsen +6 more
doaj +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
A worldwide model for boundaries of urban settlements
, 2018 The shape of urban settlements plays a fundamental role in their sustainable planning. Properly defining the boundaries of cities is challenging and remains an open problem in the Science of Cities.
Andrade Jr., José S. +3 more
core +2 more sources
Using the RE-AIM Framework to Evaluate Disaster Recovery Videos
Journal of Human Sciences and Extension, 2022 Natural disasters both increase and cause financial challenges for survivors. Crisis support reduces negative outcomes such as financial stress, yet survivors are often unaware or unable to access available services. Aiming to innovatively improve access
Sarah Cronin +2 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source