Results 41 to 50 of about 1,328,475 (288)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Techne, 2022 «Today, 600 million people in Africa do not have access to electricity and 900 million lack access to clean cooking facilities» (IEA, 2019). With this premise, the paper will explain the research agenda of the African Off-grid Housing project on how to ...
Paolo Cascone +4 more
doaj +1 more source
Arts in Cities - Cities in Arts
Articulo – revue de sciences humaines, 2017 The presence of cities in art and the presence of art in cities are two fields which have often been studied separately, be it by different disciplines (history, geography, sociology, etc.) or by various approaches within a single discipline (cultural geography or urban geography for example).
Molina, Géraldine, Guinard, Pauline
openaire +3 more sources
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
City Festivals and Festival Cities [PDF]
, 2020 This chapter discusses the role of city festivals in shaping and re-imagining urban space. There has been increased interest in festivals among decision-makers and marketers as vehicles for cultural profiling, regeneration, and social inclusion. The chapter views space as inseparable from economic and social structures and practices which govern urban ...
openaire +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
“BIOPOLIS”: Biopolicy for Greener and More Livable Cities
Cadmus, 2013 Urban centers are the engines which must bear the brunt of required changes to meet climate change mitigation goals, whilst continuing to provide social and economic opportunities.
“BIOPOLIS”: Biopolicy for Greener and More Livable Cities
doaj
Collective Impact Partnerships: The Data to Action Hourglass Model
Interdisciplinary Journal of Partnership Studies, 2022 Models are needed to guide positive health care and social transformation using real-world data, particularly in an era of data-driven science and accountability.
Karen Monsen +6 more
doaj +1 more source