Results 41 to 50 of about 1,031,008 (313)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Comparing Postoperative Outcomes of Isolated Anterior Cruciate Ligament Reconstruction and the “Terrible Triad” Anterior Cruciate Ligament Reconstruction With Medial Meniscus Ramp and Lateral Meniscus Root Repairs

Orthopaedic Journal of Sports Medicine
Background: A new “terrible triad” has been reported to be an anterior cruciate ligament (ACL) tear with a concomitant medial meniscus ramp tear and lateral meniscus root tear.
Evan P. Shoemaker BA, Luke V. Tollefson BS, Nicholas I. Kennedy MD, Rebecca Stone McGaver MS, ATC, Morgan Homan DO, Kayla J. Sieffert BA, Ayush D. Shah BA, Corey A. Wulf MD, Christopher M. Larson MD, Brian P. Bjerke MD, Robert F. LaPrade MD, PhD   +10 more
doaj   +1 more source

Excision of Femoral Heterotopic Ossification and Lysis of Adhesions After Medial Collateral Ligament Reconstruction

Arthroscopy Techniques
Heterotopic ossification (HO) and arthrofibrosis are known complications after medial collateral ligament (MCL) reconstruction and other arthroscopic procedures.
Grace Guerin, B.S., Taidhgin Keel, B.S., Luke V. Tollefson, B.S., Evan P. Shoemaker, B.A., Erik L. Slette, M.D., Nathan J. Jacobson, M.D., Robert F. LaPrade, M.D., Ph.D.   +6 more
doaj   +1 more source

Towards cloud based big data analytics for smart future cities [PDF]

, 2015
A large amount of land-use, environment, socio-economic, energy and transport data is generated in cities. An integrated perspective of managing and analysing such big data can answer a number of science, policy, planning, governance and business ...
Anjum, Ashiq, Soomro, Kamran, Tahir, Muhammad, Khan, Zaheer, Tahir, Muhammad Atif, Soomro, Kamran Ahmed   +5 more
core   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Chapter 9 Relational Agency and the Local Governance of Climate Change [PDF]

, 2015
Drawing upon a variety of empirical and theoretical perspectives, The Urban Climate Challenge provides a hands-on perspective about the political and technical challenges now facing cities and transnational urban networks in the global climate regime ...
Aylett, Alexander
core   +1 more source

Regional hippocampal thinning and gyrification abnormalities and associated cognition in children with prenatal alcohol exposure

Journal of Neurodevelopmental Disorders
Background Prenatal alcohol exposure (PAE) impacts hippocampal structure and function, contributing to deficits in memory and decision-making in affected individuals.
Blake A. Gimbel, Jeffrey R. Wozniak, Bryon A. Mueller, Kent A. Tuominen, Abigail M. Ernst, Mary E. Anthony, Erik de Water, the CIFASD, Donovan J. Roediger   +8 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Biplanar Anterior Opening Wedge Proximal Tibial Osteotomy to Correct Reverse Tibial Slope

Video Journal of Sports Medicine
Background: Anatomically, native posterior tibial slope (PTS) ranges from 6° to 10° and have significant effects on cruciate ligament stability. PTS
Conner Olson MPH, Luke V. Tollefson BS, Evan P. Shoemaker BA, Nicholas I. Kennedy MD, Robert F. LaPrade MD, PhD   +4 more
doaj   +1 more source