Results 51 to 60 of about 1,390,912 (292)

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

Biplanar Anterior Opening Wedge Proximal Tibial Osteotomy to Correct Reverse Tibial Slope

Video Journal of Sports Medicine
Background: Anatomically, native posterior tibial slope (PTS) ranges from 6° to 10° and have significant effects on cruciate ligament stability. PTS
Conner Olson MPH, Luke V. Tollefson BS, Evan P. Shoemaker BA, Nicholas I. Kennedy MD, Robert F. LaPrade MD, PhD   +4 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Shrinking cities in Australia

, 2007
Shrinkage is not a topic of much discussion in most OECD countries where the planning paradigm of growth has dominated the scene for many years. However, the debate has recently intensified in Germany, especially regarding its Eastern cities, posing new ...
Martinez-Fernandez, Cristina, Wu, Chung-Tong   +1 more
core  

Isolated Talonavicular Arthrodesis as Treatment for Flexible Progressive Collapsing Foot Deformity: A Case Series

Foot & Ankle Orthopaedics
Background: For the younger, more active patient with flexible symptomatic progressive collapsing foot deformity (PCFD), joint-sparing procedures may be preferred to preserve functional motion.
Christopher J. Traynor MD, Hui Zhang MD, Bryan D. Den Hartog MD, Jeffrey D. Seybold MD, William M. Engasser MD, Rebecca Stone McGaver MS, ATC, Jacquelyn E. Fritz BS, Kayla J. Seiffert BA, Carissa C. Dock BS, J. Chris Coetzee MD   +9 more
doaj   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Inequality and rising levels of socio-economic segregation : lessons from a pan-European comparative study [PDF]

, 2015
The research leading to these results has received funding from the Estonian Research Council (Institutional Research Grant IUT no. 2–17 on Spatial Population Mobility and Geographical Changes in Urban Regions); the European Research Council under the ...
Musterd, Sako, van Ham, Maarten, Marcińczak, Szymon, Tammaru, Tiit   +3 more
core   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Anatomic Anterolateral Ligament Reconstruction Using the Iliotibial Band Results in Less Internal Rotation Constraint and Lateral Compartment Joint Loading As Compared With the Modified Lemaire Procedure: A Robotic Biomechanical Study

Orthopaedic Journal of Sports Medicine
Background: While current anterolateral complex knee procedures have been demonstrated to reduce anterior cruciate ligament reconstruction (ACLR) graft failures, concerns about potential lateral compartment overload are present.
Luke V. Tollefson BS, Erik L. Slette MD, Evan P. Shoemaker BA, Mitchell R. Carlson MS, Matthew T. Rasmussen MD, Dustin R. Lee MD, Nicholas I. Kennedy MD, Christopher M. LaPrade MD, Robert F. LaPrade MD, PhD   +8 more
doaj   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source