Results 41 to 50 of about 2,932,973 (293)

Cities Building Community Wealth [PDF]

, 2015
As cities struggle with rising inequality, widespread economic hardship, and racial disparities, something surprising and hopeful is also stirring.
Majorie Kelly, Sarah McKinley, Violeta Duncan   +2 more
core  

“BIOPOLIS”: Biopolicy for Greener and More Livable Cities

Cadmus, 2013
Urban centers are the engines which must bear the brunt of required changes to meet climate change mitigation goals, whilst continuing to provide social and economic opportunities.
“BIOPOLIS”: Biopolicy for Greener and More Livable Cities
doaj  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Regional hippocampal thinning and gyrification abnormalities and associated cognition in children with prenatal alcohol exposure

Journal of Neurodevelopmental Disorders
Background Prenatal alcohol exposure (PAE) impacts hippocampal structure and function, contributing to deficits in memory and decision-making in affected individuals.
Blake A. Gimbel, Jeffrey R. Wozniak, Bryon A. Mueller, Kent A. Tuominen, Abigail M. Ernst, Mary E. Anthony, Erik de Water, the CIFASD, Donovan J. Roediger   +8 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Smart & sustainable cities [PDF]

, 2013
The University of Strathclyde is creating a new Institute for Future Cities that aims to improve the quality of human life across the world through innovative research that enables cities to be understood in new ways, and innovative approaches to be ...
Bellingham, Richard, Purshouse, Nicholas
core  

Biplanar Anterior Opening Wedge Proximal Tibial Osteotomy to Correct Reverse Tibial Slope

Video Journal of Sports Medicine
Background: Anatomically, native posterior tibial slope (PTS) ranges from 6° to 10° and have significant effects on cruciate ligament stability. PTS
Conner Olson MPH, Luke V. Tollefson BS, Evan P. Shoemaker BA, Nicholas I. Kennedy MD, Robert F. LaPrade MD, PhD   +4 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Fresh Osteochondral Allograft to Medial Femoral Condyle With Proximal Tibial Opening Wedge Osteotomy

Video Journal of Sports Medicine
Background: Contributors to knee degeneration include mechanical axis malalignment, patellar maltracking, meniscal deficiency, and tibiofemoral instability.
Evan P. Shoemaker BA, Luke V. Tollefson BS, Conner Olson MPH, Nicholas I. Kennedy MD, Robert F. LaPrade MD, PhD   +4 more
doaj   +1 more source