Results 21 to 30 of about 551 (132)

Organoids from colorectal peritoneal metastases as a platform for improving hyperthermic intraperitoneal chemotherapy

open access: yesBJS (British Journal of Surgery), Volume 106, Issue 10, Page 1404-1414, September 2019., 2019
Organoid technology was used to create a preclinical model for evaluation of hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal metastases from colorectal cancer. Current HIPEC regimens were tested and a novel rational treatment combination of mitomycin C with inhibitors of ATR was investigated.
I. Ubink   +13 more
wiley   +1 more source

Modelo de detección de anticuerpos neutralizantes contra IFN-β mediante citometría de flujo

open access: yesBiomédica: revista del Instituto Nacional de Salud, 2012
Introducción. El interferón beta (IFN-β) se usa para tratar la forma recaída-remisión de la esclerosis múltiple. Sin embargo, el uso de proteínas recombinantes como medicamentos puede generar la producción de anticuerpos, disminuyendo así la efectividad ...
Juan Carlos Villa-Camacho   +2 more
doaj   +1 more source

Inhibins regulate peripheral regulatory T cell induction through modulation of dendritic cell function

open access: yesFEBS Open Bio, Volume 9, Issue 1, Page 137-147, January 2019., 2019
Dendritic cells (DCs) play a key role in the induction of peripherally induced regulatory T cells (Tregs) under homeostatic and inflammatory conditions. This study demonstrates that inhibins modulate the induction of Tregs from naïve T cells in the periphery through promoting DC maturation and function.
Marisol de la Fuente‐Granada   +4 more
wiley   +1 more source

Cancer Stem Cells from Tumor Cell Lines Activate the DNA Damage Response Pathway after Ionizing Radiation More Efficiently Than Noncancer Stem Cells

open access: yesStem Cells International, Volume 2019, Issue 1, 2019., 2019
Recently, a subpopulation of tumor cells, called cancer stem cells (CSC), has been characterized, and these have emerged as a major topic in cancer research. CSC are proposed to repair DNA damage more efficiently than the rest of tumor cells, resisting chemotherapy or radiotherapy and causing clinical recurrence and metastasis.
Heriberto Abraham Valencia-González   +4 more
wiley   +1 more source

El sistema genético de Paspalum lilloi (Poaceae), especie endémica de las Cataratas del Iguazú

open access: yesBoletín de la Sociedad Argentina de Botánica, 2021
Introducción y objetivos: Paspalum lilloi (Poaceae) es una especie diploide y endémica de las Cataratas del Iguazú y áreas circundantes, cuya biología reproductiva y área de distribución geográfica actual es desconocida. Los objetivos de este trabajo son
Anna Verena Reutemann   +5 more
doaj   +3 more sources

Engineering Nanocellulose Scaffolds: Property Modification Strategies and Mechanotransduction‐Driven Tissue Outcomes

open access: yesPolymers for Advanced Technologies, Volume 37, Issue 3, March 2026.
ABSTRACT Nanocellulose is being increasingly used in biomedical applications because of its biocompatibility, mechanical robustness, tunable surface chemistry, and adjustable rheology. This review evaluates recent strategies for engineering cellulose nanofibrils, nanocrystals, and bacterial nanocellulose into cell‐instructive scaffolds for skin, bone ...
Aurora Rodríguez Martínez   +6 more
wiley   +1 more source

Genes Involved in the Transcriptional Regulation of Pluripotency Are Expressed in Malignant Tumors of the Uterine Cervix and Can Induce Tumorigenic Capacity in a Nontumorigenic Cell Line

open access: yesStem Cells International, Volume 2019, Issue 1, 2019., 2019
Transcription factors OCT4, SOX2, KLF4, C‐MYC, and NANOG (OSKM‐N) regulate pluripotency and stemness, and their ectopic expression reprograms human and murine fibroblasts that constitute the key of regenerative medicine. To determine their contribution to cell transformation, we analyzed the gene expression profiles of these transcription factors in ...
Graciela Ruiz   +10 more
wiley   +1 more source

Estimación del tamaño del genoma en especies de la tribu Cestreae (Solanaceae) mediante citometría de imagen.

open access: yesBoletín de la Sociedad Argentina de Botánica, 2015
Los géneros Cestrum, Sessea y Vestia pertenecen a la tribu Cestreae y presentan varias características cromosómicas que los diferencian de otras especies de Solanaceae, como el número y tamaño cromosómico.
Aquiles Frossasco   +2 more
doaj   +1 more source

Nanoparticles targeting monocytes and macrophages as diagnostic and therapeutic tools for autoimmune diseases

open access: yesHeliyon, 2023
Autoimmune diseases are chronic conditions that result from an inadequate immune response to self-antigens and affect many people worldwide. Their signs, symptoms, and clinical severity change throughout the course of the disease, therefore the diagnosis
Karen Álvarez, Mauricio Rojas
doaj   +1 more source

Inhibition of RAD51 by siRNA and Resveratrol Sensitizes Cancer Stem Cells Derived from HeLa Cell Cultures to Apoptosis

open access: yesStem Cells International, Volume 2018, Issue 1, 2018., 2018
Cervical cancer is the second most frequent tumor type in women worldwide with cases developing clinical recurrence, metastasis, and chemoresistance. The cancer stem cells (CSC) may be implicated in tumor resistance to therapy. RESveratrol (RES), a natural compound, is an antioxidant with multiple beneficial activities.
Graciela Ruíz   +6 more
wiley   +1 more source

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