Results 61 to 70 of about 512,389 (298)

Efficacy of Sildenafil Citrate in Treatment of Primary Premature Ejaculation in Men [PDF]

open access: diamond, 2023
Ahmed Abdel Fattah   +3 more
openalex   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

open access: yesAdvanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley   +12 more
wiley   +1 more source

Hepatic Ketogenesis Induced by Middle Cerebral Artery Occlusion in Mice

open access: yesJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundKetone bodies are known to substitute for glucose as brain fuel when glucose availability is low. Ketogenic diets have been described as neuroprotective. Similar data have been reported for triheptanoin, a fatty oil and anaplerotic compound. In
Konrad Koch   +5 more
doaj   +1 more source

Acid ion modification in a dialysis fluid

open access: yesВестник трансплантологии и искусственных органов, 2020
Apart from its main electrolytes – sodium, potassium, calcium and magnesium – a dialysis fluid (DF) contains a buffer for correction of acidosis. A small amount of acid is added to the DF to prevent calcium and magnesium precipitation.
I. L. Poz, A. G. Strokov
doaj   +1 more source

Unleashing the Power of Machine Learning in Nanomedicine Formulation Development

open access: yesAdvanced Functional Materials, EarlyView.
A random forest machine learning model is able to make predictions on nanoparticle attributes of different nanomedicines (i.e. lipid nanoparticles, liposomes, or PLGA nanoparticles) based on microfluidic formulation parameters. Machine learning models are based on a database of nanoparticle formulations, and models are able to generate unique solutions
Thomas L. Moore   +7 more
wiley   +1 more source

A Role for the Krebs Cycle Intermediate Citrate in Metabolic Reprogramming in Innate Immunity and Inflammation

open access: yesFrontiers in Immunology, 2018
Metabolism in immune cells is no longer thought of as merely a process for adenosine triphosphate (ATP) production, biosynthesis, and catabolism. The reprogramming of metabolic pathways upon activation is also for the production of metabolites that can ...
Niamh C. Williams, Luke A. J. O’Neill
doaj   +1 more source

Tuning the Electronic Structure and Spin State of Fe─N─C Catalysts Using an Axial Oxygen Ligand and Fe Clusters for High‐Efficiency Rechargeable Zinc–Air Batteries

open access: yesAdvanced Functional Materials, EarlyView.
A FeN4─O/Clu@NC‐0.1Ac catalyst containing atomically‐dispersed FeN4─O sites (medium‐spin Fe2+) and Fe clusters delivered a half‐wave potential of 0.89 V for ORR and an overpotential of 330 mV at 10 mA cm−2 for OER in 0.1 m KOH. When the catalyst was used in a rechargeable Zn–air battery, a power density of 284.5 mW cm−2 was achieved with excellent ...
Yongfang Zhou   +8 more
wiley   +1 more source

Controlled Movement of Soft Actuators using Multi‐Responsive Microgel Arrays and Microcirculatory Systems

open access: yesAdvanced Functional Materials, EarlyView.
Microscale hydrogels (microgels) feature improved mass transport characteristics supportive of fast actuation and chemical tunability amenable to programmed stimuli response. A unique soft actuator architecture is realized by encapsulating microgels in soft microcirculatory systems which enable the convenient delivery of liquid stimuli for powering and
Nengjian Huang   +2 more
wiley   +1 more source

Separation of REs from Ca and Mg Ions by Ammonium Bicarbonate Precipitation and the Influence of Fe and Al Ions

open access: yesMetals
The presence of impurities such as Ca, Mg, and Al during the precipitation of rare earths (REs) using ammonium bicarbonate directly affects product purity.
Yanzhu Liu   +5 more
doaj   +1 more source

Crystal structure of caesium dihydrogen citrate from laboratory X-ray powder diffraction data and DFT comparison

open access: yesActa Crystallographica Section E: Crystallographic Communications, 2017
The crystal structure of caesium dihydrogen citrate, Cs+·H2C6H5O7−, has been solved and refined using laboratory X-ray powder diffraction data, and optimized using density functional techniques.
Alagappa Rammohan, James A. Kaduk
doaj   +1 more source

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