STAT3 Regulation of Citrate Synthase Is Essential during the Initiation of Lymphocyte Cell Growth [PDF]
Cell Reports, 2017 Summary: Citrate is a required carbon precursor for de novo fatty acid and membrane lipid synthesis. However, the pathways regulating intracellular citrate, particularly during the initial transition from a resting state to cell growth, remain unclear ...
Sarah MacPherson +5 more
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Extra-mitochondrial citrate synthase initiates calcium oscillation and suppresses age-dependent sperm dysfunction. [PDF]
Lab Invest, 2020 Men and women become infertile with age, but the mechanism of declining male fertility, more specifically, the decrease in in sperm quality, is not well known.
Kang W +13 more
europepmc +4 more sources
Effect of downregulated citrate synthase on oxidative phosphorylation signaling pathway in HEI-OC1 cells [PDF]
Proteome Science, 2022 Background Citrate Synthase (Cs) gene mutation (locus ahL4) has been found to play an important role in progressive hearing loss of A/J mice. HEI-OC1 cells have been widely used as an in vitro system to study cellular and molecular mechanisms related to ...
Xiaowen Xu +9 more
doaj +4 more sources
Bacterial cell cycle control by citrate synthase independent of enzymatic activity [PDF]
eLife, 2020 Proliferating cells must coordinate central metabolism with the cell cycle. How central energy metabolism regulates bacterial cell cycle functions is not well understood.
Matthieu Bergé +6 more
doaj +3 more sources
The Novel Role of Mitochondrial Citrate Synthase and Citrate in the Pathophysiology of Alzheimer's Disease. [PDF]
J Alzheimers Dis, 2023 Citrate synthase is a key mitochondrial enzyme that utilizes acetyl-CoA and oxaloacetate to form citrate in the mitochondrial membrane, which participates in energy production in the TCA cycle and linked to the electron transport chain.
Chhimpa N, Singh N, Puri N, Kayath HP.
europepmc +2 more sources
Citrate Synthase and OGDH as Potential Biomarkers of Atherosclerosis under Chronic Stress. [PDF]
Oxid Med Cell Longev, 2021 Background Pathological changes of the adrenal gland and the possible underlying molecular mechanisms are currently unclear in the case of atherosclerosis (AS) combined with chronic stress (CS).
Meng LB +9 more
europepmc +2 more sources
Allosteric role of the citrate synthase homology domain of ATP citrate lyase [PDF]
Nature Communications, 2023 ATP citrate lyase (ACLY) is the predominant nucleocytosolic source of acetyl-CoA and is aberrantly regulated in many diseases making it an attractive therapeutic target.
Xuepeng Wei +6 more
doaj +2 more sources
Citrate synthase from Synechocystis is a distinct class of bacterial citrate synthase. [PDF]
Sci Rep, 2019 Citrate synthase (CS, EC 2.3.3.1) catalyses the initial reaction of the tricarboxylic acid (TCA) cycle. Although CSs from heterotrophic bacteria have been extensively studied, cyanobacterial CSs are not well-understood.
Ito S, Koyama N, Osanai T.
europepmc +2 more sources
Production of Esters in Escherichia coli Using Citrate Synthase Variants [PDF]
MicroorganismsAcetate esters comprise a wide range of products including fragrances and industrial solvents. Biosynthesis of esters offers a promising alternative to chemical synthesis because such routes use renewable carbohydrate resources and minimize the ...
Jacoby C. Shipmon +4 more
doaj +2 more sources
Low Citrate Synthase Activity Is Associated with Glucose Intolerance and Lipotoxicity. [PDF]
J Nutr Metab, 2019 Citrate synthase (CS) is a key mitochondrial enzyme. The aim of this study was to test the hypothesis that low CS activity impairs the metabolic health of mice fed a high fat diet (HFD) and promotes palmitate-induced lipotoxicity in muscle cells.
Alhindi Y +10 more
europepmc +2 more sources