Results 31 to 40 of about 490,642 (236)

LC-MS proteomics analysis of the iInsulin/IGF-1-deficient Caenorhabditis elegans daf-2(e1370) mutant reveals extensive restructuring of intermediary metabolism [PDF]

, 2014
The insulin/IGF-1 receptor is a major known determinant of dauer formation, stress resistance, longevity, and metabolism in Caenorhabditis elegans. In the past, whole-genome transcript profiling was used extensively to study differential gene expression ...
Braeckman, Bart, Brewer, Heather M, Camp, David G, II, Depuydt, Geert, Petyuk, Vladislav A, Smith, Richard D, Smolders, Arne, Xie, Fang   +7 more
core   +2 more sources

Fatty acid flux suppresses fatty acid synthesis in hamster intestine independently of SREBP-1 expression

Journal of Lipid Research, 2003
Hamsters were fed a control diet or diets containing palm, olive, safflower, or fish oil for 2 weeks. In villus cell populations from duodenum, jejunum, and ileum, rates of intestinal fatty acid and cholesterol synthesis were estimated, as were sterol ...
F. Jeffrey Field, Ella Born, Satya N. Mathur   +2 more
doaj   +1 more source

Inibição da atividade da citrato sintase cerebral em um modelo animal de sepse Inhibition of brain citrate synthase activity in an animal model of sepsis

Revista Brasileira de Terapia Intensiva, 2011
OBJETIVO: Um amplo corpo de evidência oriundo de estudos experimentais indica que a sepse se associa com um aumento da produção de espécies de oxigênio reativo, depleção de antioxidantes, e acúmulo de marcadores de estresse oxidativo.
Giselli Scaini, Natália Rochi, Joana Benedet, Gabriela Kozuchovski Ferreira, Brena Pereira Teodorak, Clarissa Martinelli Comim, Larissa de Souza Constantino, Francieli Vuolo, Leandra Celso Constantino, João Quevedo, Emilio Luiz Streck, Felipe Dal-Pizzol   +11 more
doaj   +1 more source

(-)-Hydroxycitric Acid Reduced Lipid Droplets Accumulation Via Decreasing Acetyl-Coa Supply and Accelerating Energy Metabolism in Cultured Primary Chicken Hepatocytes

Cellular Physiology and Biochemistry, 2017
Background/Aims: (-)-Hydroxycitric acid (HCA) had been shown to suppress fat accumulation in animals and humans, while the underlying biochemical mechanism is not fully understood, especially little information is available on whether (-)-HCA regulates ...
Longlong Li, Mengling Peng, Chongyang Ge, Lei Yu, Haitian Ma   +4 more
doaj   +1 more source

The glycolytic enzyme phosphofructokinase-1 assembles into filaments. [PDF]

, 2017
Despite abundant knowledge of the regulation and biochemistry of glycolytic enzymes, we have limited understanding on how they are spatially organized in the cell.
Albe, Anne M. Dosey, Attanasio, Barry, Beaty, Beckner, Bradley A. Webb, Brüser, Clarke, Cohen, De Bock, Diane L. Barber, Egelman, Egelman, Eisenberg, Foe, Frey, Gunning, Habrian, Ingerson-Mahar, Jang, Jia, Justin M. Kollman, Kemp, Kim, Lander, Li, Liu, Mahboubi, Meredith, Noree, Olsen, O’Connell, Ranjit, Reinhart, Rohou, Scheres, Scheres, Schindelin, Segall, Shaikh, Shen, Sievers, Stehbens, Stehbens, Suloway, Torsten Wittmann, Trujillo, Wang, Webb   +49 more
core   +1 more source

Inhibiting PHGDH with NCT-503 reroutes glucose-derived carbons into the TCA cycle, independently of its on-target effect

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
The small-molecule inhibitor of phosphoglycerate dehydrogenase, NCT-503, reduces incorporation of glucose-derived carbons into serine in vitro.
Birte Arlt, Guido Mastrobuoni, Jasmin Wuenschel, Kathy Astrahantseff, Angelika Eggert, Stefan Kempa, Hedwig E. Deubzer   +6 more
doaj   +1 more source

Minimizing acetate formation in E. coli fermentations [PDF]

, 2007
Escherichia coli remains the best established production organisms in industrial biotechnology. However, during aerobic fermentation runs at high growth rates, considerable amounts of acetate are accumulated as by-product.
De Maeseneire, Sofie, De Mey, Marjan, Soetaert, Wim, Vandamme, Erick   +3 more
core   +2 more sources

Multiscale analysis of enantioselectivity in enzyme-catalysed ‘lethal synthesis’ using projector-based embedding [PDF]

Royal Society Open Science, 2018
The action of fluoroacetate as a broad-spectrum mammalian pesticide depends on the ‘lethal synthesis’ of fluorocitrate by citrate synthase, through a subtle enantioselective enolization of fluoroacetyl-coenzyme A.
Xinglong Zhang, Simon J. Bennie, Marc W. van der Kamp, David R. Glowacki, Frederick R. Manby, Adrian J. Mulholland   +5 more
doaj   +1 more source

Characterization of a sperm factor for egg activation at fertilization of the newt Cynops pyrrhogaster [PDF]

, 2007
Eggs of the newt, Cynops pyrrhogaster, arrested at the second meiotic metaphase are activated by sperm at fertilization and then complete meiosis to initiate development.
Yuichirou Harada, Tamami Matsumoto, Shino Hirahara, Akira Nakashima, Shuichi Ueno, Shoji Oda, Shunichi Miyazaki, Yasuhiro Iwao, Coux, Coward, Coward, Dong, Dumollard, Dumollard, Dumollard, Eisen, Fujimoto, Girard, Glahn, Hajnoczky, Iwao, Iwao, Iwao, Iwao, Iwao, Iwao, Jouaville, Kojima, Kouchi, Kurokawa, Kyozuka, Mahbub Hasan, Mak, Marinos, Matwee, Miyazaki, Mizote, Neufeld, Numata, Numata, Oda, Parrington, Picheral, Picheral, Rizzuto, Rosenkrantz, Sakakibara, Sato, Sato, Sato, Sato, Saunders, Shakespeare, Shilling, Shilling, Stricker, Swann, Swann, Swann, Takeda, Townley, Whitaker, Yamamoto, Yamamoto, Yoda   +64 more
core   +2 more sources

Is acetylation a metabolic rheostat that regulates skeletal muscle insulin action? [PDF]

, 2015
Skeletal muscle insulin resistance, which increases the risk for developing various metabolic diseases, including type 2 diabetes, is a common metabolic disorder in obesity and aging.
LaBarge, Samuel, Migdal, Christopher, Schenk, Simon   +2 more
core   +2 more sources