Results 81 to 90 of about 490,642 (236)

Leukocyte as an adequate model for studying changes in energy metabolism in heart cells under the influence of cardiocytoprotectors in myocardial ischemia

Acta Biomedica Scientifica
The aim of this study was to determine the possibility of studying the nature of the influence of cardiocytoprotectors on energy metabolism in cardiomyocytes using a model of human peripheral blood leukocytes.Materials and methods. Sixty Wistar rats were
A. L. Khokhlov, O. V. Romashchenko, V. V. Rumbesht, T. I. Yakunchenko, N. I. Zhernakova, L. R. Zakirova, V. G. Kukes   +6 more
doaj   +1 more source

The impact of RNA binding proteins and the associated long non-coding RNAs in the TCA cycle on cancer pathogenesis

RNA Biology, 2023
The tricarboxylic acid (TCA) cycle is a central route for generating cellular energy and precursors for biosynthetic pathways. Emerging evidences have shown that the aberrations of metabolic enzymes which affect the integrity of TCA cycle are implicated ...
Tao Shen, Haiyang Wang, Bin Tang, Guoping Zhu, Xiangting Wang   +4 more
doaj   +1 more source

Transcriptional adaptation of Mycobacterium tuberculosis within macrophages: Insights into the phagosomal environment [PDF]

, 2003
Little is known about the biochemical environment in phagosomes harboring an infectious agent. To assess the state of this organelle we captured the transcriptional responses of Mycobacterium tuberculosis (MTB) in macrophages from wild-type and nitric ...
Butcher, PD, Dolganov, G, Efron, B, Ehrt, S, Liu, Y, Mangan, JA, Monahan, IM, Nathan, C, Schnappinger, D, Schoolnik, GK, Voskuil, MI   +10 more
core   +3 more sources

SbnG, a Citrate Synthase in Staphylococcus aureus

Journal of Biological Chemistry, 2014
Background: Staphylococcus aureus contains a second, iron-regulated citrate synthase. Results: SbnG is a citrate synthase within the phosphoenolpyruvate/pyruvate superfamily.
M. Kobylarz, J. C. Grigg, J. Sheldon, D. Heinrichs, Michael E. P. Murphy   +4 more
semanticscholar   +1 more source

Metabolism Analysis in Mice with Reduced Citrate Synthase Activity

Baltic Journal of Sport and Health Sciences, 2018
Background.  Citrate  synthase  (CS)  plays  an  important  role  in  the  regulation  of  carbohydrate  oxidation. Variation in citrate synthase activity has an influence on metabolic changes.
Andrej Fokin, Petras Minderis, Rasa Žūkienė, Aivaras Ratkevičius   +3 more
doaj   +1 more source

Tricarboxylic acid cycle enzyme activities in a mouse model of methylmalonic aciduria [PDF]

, 2019
Methylmalonic acidemia (MMA) is a propionate pathway disorder caused by dysfunction of the mitochondrial enzyme methylmalonyl-CoA mutase (MMUT). MMUT catalyzes the conversion of methylmalonyl-CoA to succinyl-CoA, an anaplerotic reaction which feeds into ...
Baumgartner, Matthias R, Chapman, Kimberly A, Cunningham, Gary, Forny, Patrick, Pumbo, Elena, Summar, Marshall L, Wongkittichote, Parith   +6 more
core   +1 more source

The effect of autophagy and mitochondrial fission on Harderian gland is greater than apoptosis in male hamsters during different photoperiods.

PLoS ONE, 2020
Photoperiod is an important factor of mammalian seasonal rhythm. Here, we studied morphological differences in the Harderian gland (HG), a vital photosensitive organ, in male striped dwarf hamsters (Cricetulus barabensis) under different photoperiods ...
Jin-Hui Xu, Zhe Wang, Jun-Jie Mou, Xiang-Yu Zhao, Xiao-Cui Geng, Ming Wu, Hui-Liang Xue, Lei Chen, Lai-Xiang Xu   +8 more
doaj   +1 more source

Mitochondrial dysfunction in skeletal muscle contributes to the development of acute insulin resistance in mice

Journal of Cachexia, Sarcopenia and Muscle, 2021
Background Although mounting evidence indicates that insulin resistance (IR) co‐occurs with mitochondrial dysfunction in skeletal muscle, there is no clear causal link between mitochondrial dysfunction and IR pathogenesis.
Hyunjung Lee, Tae Youl Ha, Chang Hwa Jung, Farida Sukma Nirmala, So‐Young Park, Yang Hoon Huh, Jiyun Ahn   +6 more
doaj   +1 more source

Tempol Supplementation Restores Diaphragm Force and Metabolic Enzyme Activities in mdx Mice

Antioxidants, 2017
Duchenne muscular dystrophy (DMD) is characterized by striated muscle weakness, cardiomyopathy, and respiratory failure. Since oxidative stress is recognized as a secondary pathology in DMD, the efficacy of antioxidant intervention, using the superoxide ...
David P. Burns, Izza Ali, Clement Rieux, James Healy, Greg Jasionek, Ken D. O’Halloran   +5 more
doaj   +1 more source

KNR4, a suppressor of Saccharomyces cerevisiae cwh mutants, is involved in the transcriptional control of chitin synthase genes [PDF]

, 1999
The KNR4 gene, originally isolated by complementation of a K9 killer-toxinresistant mutant displaying reduced levels of both 1,3-b-glucan and 1,3-bglucan synthase activity, was recloned from a YCp50 genomic library as a suppressor of Saccharomyces ...
Dagkessamanskaia, Adilia, Dallies, Nathalie, Francois, Jean, Martin, Helene, Satchanska, Galina   +4 more
core   +3 more sources