Results 231 to 240 of about 32,011 (309)

Study protocol for a randomized single-center cross-over study: Dapagliflozin treatment in recurring kidney stone patients. [PDF]

PLoS One
Omić H, Eder M, Herkner H, Seitz C, Kikić Ž, Schrag TA.   +5 more
europepmc   +1 more source

Cytokine mRNA Delivery and Local Immunomodulation in the Placenta Using Lipid Nanoparticles

Advanced Therapeutics, EarlyView.
This article evaluates lipid nanoparticles to deliver immunomodulatory mRNA to placental cells and mouse placentas to study and treat the immune underpinnings of placenta‐related diseases. Lipid nanoparticles induce cytokine secretion and macrophage polarization toward an anti‐inflammatory state.
Samuel I. Hofbauer, Luisa A. Fink, Rachel E. Young, Tara Vijayakumar, Katherine M. Nelson, Nia Bellopede, Mohamad‐Gabriel Alameh, Drew Weissman, Jason P. Gleghorn, Rachel S. Riley   +9 more
wiley   +1 more source

SMYD3 Promotes Immune Evasion in Clear Cell Renal Cell Carcinoma via SREBP1‐Mediated Transactivation of CD47

Advanced Science, EarlyView.
Cancer cell‐intrinsic SMYD3 orchestrates an immunosuppressive microenvironment and impairs the response to PD‐1 blockade by reprogramming immune cells landscape in the tumor microenvironment of clear cell renal cell carcinoma (ccRCC). The immunomodulatory function of SMYD3 is mediated via the SREBP1/CD47 pathway.
Zhengfang Liu, Xiumei Zhao, Maolin Zang, Huiyang Yuan, Xin Qin, Xiaofeng Li, Shuo Zhao, Ruirong Tan, Keqiang Yan, Li Liu, Yidong Fan, Ning Zhang, Benkang Shi, Bo Han, Shouzhen Chen   +14 more
wiley   +1 more source

The Citrate Cleavage Enzyme

, 1961
Paul A. Srere
openalex   +1 more source

Lecithin Alleviates Memory Deficits and Muscle Attenuation in Chinese Older Adults and SAMP8 Mice

Advanced Science, EarlyView.
This study opens a new avenue for safeguarding cognition and muscle health, averting disability in older age, and treating age‐related pathologies through lecithin supplementation. It serves as a promising nonpharmacological intervention for the crosstalk of muscle and cognition.
Xianyun Wang, Dajun Li, Xiao Ying Li, Weizhao Lu, Huini Ding, Chengyan Qi, Xuan Wang, Jing Shen, Yafei Chi, Tiantian Li, Michelle M. Dunk, Yu An, Hongmei Huang, Kang Yu, Weili Xu, Rong Xiao, Yuandi Xi   +16 more
wiley   +1 more source

Evaluation of plasma nucleosome concentrations and the effect of pre-analytical variables in healthy cats. [PDF]

BMC Vet Res
Westerback E, Wilson-Robles H, Bougoussa M, Istvan S, Stewart S, Warry E, Heinz J.   +6 more
europepmc   +1 more source

Multivariate Screening and Automated Clustering of Macrophage Immunoreactome to Nanoparticles and Photothermal Therapy

Advanced Science, EarlyView.
Predicting immune responses to treatments, including nanomedicines, with high throughput test is challenging due to the immunoreactome's complexity and plasticity. A predictive screening platform integrating pathway activation and gene profiling in macrophages has been developed as a versatile tool for designing effective immunotherapies.
Sonia Becharef, Léa Jabbour, Nassima Bekaddour, Giulio Avveduto, Nathalie Luciani, Gautier Laurent, Rana Bazzi, Edouard Alphandery, Stéphane Roux, Amanda K. A. Silva, Kelly Aubertin, Jean‐Philippe Herbeuval, Florence Gazeau   +12 more
wiley   +1 more source

Nutritional Risks of Heavy Metals in the Human Diet-Multi-Elemental Analysis of Energy Drinks. [PDF]

Nutrients
Czarnek K, Tatarczak-Michalewska M, Wójcik G, Szopa A, Majerek D, Fila K, Hamitoglu M, Gogacz M, Blicharska E.   +8 more
europepmc   +1 more source

NAD+‐Boosters Improve Mitochondria Quality Control In Parkinson's Disease Models Via Mitochondrial UPR

Advanced Science, EarlyView.
Treatment of MPTP‐incubated cells with NAD+‐boosters increase the UPRmt/mitophagy‐related mitochondria quality control (MQC). Disturbed plasma UPRmt‐mitophagy‐mediated MQC profiles in PD patient samples. NMN inhibits motor deficit and forestalls neuropathology phenotypes of PD mice, which is required the atf4‐medicated UPRmt pathway.
Shuoting Zhou, Xi Xiong, Jialong Hou, Qi Duan, Yi Zheng, Tao Jiang, Jiani Huang, Haijun He, Jiaxue Xu, Keke Chen, Wenwen Wang, Jinlai Cai, Jingjing Qian, Huijun Chen, Weihong Song, XinShi Wang, Chenglong Xie   +16 more
wiley   +1 more source

Glucose Deprivation‐Induced Disulfidptosis via the SLC7A11‐INF2 Axis: Pan‐Cancer Prognostic Exploration and Therapeutic Validation

Advanced Science, EarlyView.
Glucose deprivation or GLUT1 inhibition induces disulfidptosis in SLC7A11high ovarian cancer cells by promoting cystine accumulation, NADPH/ATP depletion, and F‐actin disulfide formation. SLC7A11 interacts with INF2 to further increase H₂O₂ levels and impair mitochondrial fission, suppressing cell migration. Targeting the SLC7A11–INF2 axis represents a
Zhenyu Song, Qiuming Yao, Lina Huang, Dan Cui, Jun Xie, Leilei Wu, Jianfeng Huang, Bo Zhai, Dan Liu, Xiao Xu   +9 more
wiley   +1 more source