Results 171 to 180 of about 4,245 (216)
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Citrinin mycotoxicosis in the rabbit
Food and Chemical Toxicology, 1983In three trials, single or multiple doses of citrinin dissolved in 0.5 N-NaOH and adjusted to neutral pH with HCl were given to rabbits by either the oral or intraperitoneal route. The 72-hr LD50 was 50 mg/kg body weight by intraperitoneal administration and 134 mg/kg by the oral route.
C, Hanika, W W, Carlton, J, Tuite
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Citrinin mycotoxicosis in the mouse
Food and Cosmetics Toxicology, 1977Abstract Citrinin was mixed in a purified diet for feeding to mice or was dissolved in sodium hydroxide (NaOH) or in equal parts of dimethylsulphoxide (DMSO) and 50% ethanol (EtOH) for administration by the ip, sc and oral routes. The single-dose LD 50 values determined in male mice at 72 hr for citrinin dissolved in DMSO-50%EtOH were 58, 73 and 112
W H, Jordon, W W, Carlton, G A, Sansing
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Experientia, 1975
Observations from preliminary experiments to discover the phytotoxicity, if any, of the fungal metabolite, citrinin, are presented. There seems to be a positive indication, warranting further investigation.
C. Damodaran +5 more
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Observations from preliminary experiments to discover the phytotoxicity, if any, of the fungal metabolite, citrinin, are presented. There seems to be a positive indication, warranting further investigation.
C. Damodaran +5 more
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Citrinin mycotoxicosis in beagle dogs
Food and Cosmetics Toxicology, 1974Abstract Three trials were completed in which young beagle dogs were either fed a citrinin-containing culture of Penicillium citrinum (Trial I) or were administered pure citrinin either ip (Trial II) or orally (Trial III). Dogs fed the fungal culture and those given 20 or 40 mg pure citrinin/kg body weight developed renal disease.
W W, Carlton +3 more
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Citrinin mycotoxicosis in the guinea-pig
Food and Cosmetics Toxicology, 1977Abstract Citrinin was dissolved in dimethylsulphoxide-ethanol solution and administered daily for 14 days by gastric intubation to young male and female guinea-pigs. Under these conditions, the LD 50 of citrinin was 43 mg/kg/day for both sexes. Loss of body weight was the most consistent clinical feature of citrinin toxicity.
H.L. Thacker, W.W. Carlton, G.A. Sansing
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Citrinin mycotoxicosis in broiler chickens
Food and Cosmetics Toxicology, 1981Citrinin, a mycotoxin, was administered to chickens by crop gavage in dimethylsulphoxide-70% ethanol (3:1, v/v) or mixed with the diet (commercial starter mash) in four separate trials. The single-dose oral LD50 value in 7-day-old male broiler chicks was found to be 95 mg/kg. The administration of seven daily doses of citrinin equal to a half and three-
N A, Mehdi, W W, Carlton, J, Tuite
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Citrinin mycotoxicosis in the syrian hamster
Food and Cosmetics Toxicology, 1978Abstract Citrinin, dissolved in either a solution of equal parts of dimethylsulphoxide (DMSO) and 50% ethanol (EtOH) or 0.5 N -sodium hydroxide (NaOH), was administered by the ip or oral route to weanling Syrian hamsters. The single-dose ip LD 50 for citrinin dissolved in DMSO-50% EtOH, determined 72 hr after injection, was 66 mg/kg: for citrinin ...
W.H. Jordan, W.W. Carlton, G.A. Sansing
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Archives of Toxicology, 2014
Citrinin (CIT) and ochratoxin A (OTA) are mycotoxins produced by several species of the genera Aspergillus, Penicillium and Monascus. Both can be present as contaminants in various food commodities and in animal feed. The occurrence and toxicity of OTA and human exposure have been intensively studied, but for CIT such data are scarce by comparison ...
Wolfram, Föllmann +2 more
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Citrinin (CIT) and ochratoxin A (OTA) are mycotoxins produced by several species of the genera Aspergillus, Penicillium and Monascus. Both can be present as contaminants in various food commodities and in animal feed. The occurrence and toxicity of OTA and human exposure have been intensively studied, but for CIT such data are scarce by comparison ...
Wolfram, Föllmann +2 more
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The structure of citrinin in vivo
Journal of the Chemical Society, Perkin Transactions 1, 19871 H- and 13C-N.m.r. spectroscopy have been used to show that in aqueous solution at physiological pH the antibiotic citrinin exists not as the quinone methide (1) but as a diastereoisomeric mixture of hydrates. The equilibrium between the two diastereoisomers is slow, suggesting that citrinin, which is believed to interact with deoxyribonucleic acid
Jill Barber +3 more
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