Results 61 to 70 of about 11,841,025 (403)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

THE CITY AND ITS IMAGE: DISCOURSES OF THEORETICAL UNDERSTANDING

open access: yesRussian Studies in Culture and Society
The article is devoted to understanding the ideas that influence the understanding of the essence of the city and its image in the process of historical development.
Maria E. Kulyan-Kozionova   +2 more
doaj   +1 more source

Le « paysage urbain » en question

open access: yesProjets de Paysage, 2011
The article presents methodological choices of a research about the notion of urban landscape. The first part outlines the issues and problems about this notion (especially through the current debates between landscape professionals and theorists) and ...
Naouel Bchir Jaber
doaj   +1 more source

The Creative Potential of the City in the Context of Digitalization

open access: yesRUDN Journal of Political Science, 2023
Limited resources, multiple crises, socio-political tensions, development imbalances, and other challenges encourage cities to search for new development resources, especially intangible ones, and policies to tap into their potential.
Andrei L. Bardin
doaj   +1 more source

City Festivals and Festival Cities [PDF]

open access: yes, 2020
This chapter discusses the role of city festivals in shaping and re-imagining urban space. There has been increased interest in festivals among decision-makers and marketers as vehicles for cultural profiling, regeneration, and social inclusion. The chapter views space as inseparable from economic and social structures and practices which govern urban ...
openaire   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

Le lombricomposteur d'appartement, les déchets et la terre urbaine

open access: yesRevue d'ethnoécologie, 2015
Swiss authorities are becoming stricter and stricter about imposing the sorting out of domestic waste, the prepaid bin bags as well as the handling of organic leftovers whose organised recycling begins in a closed circuit with the use of worms (Eisenia ...
Jacqueline Milliet
doaj   +1 more source

Security, Privacy and Risks Within Smart Cities: Literature Review and Development of a Smart City Interaction Framework

open access: yesInformation Systems Frontiers, 2020
The complex and interdependent nature of smart cities raises significant political, technical, and socioeconomic challenges for designers, integrators and organisations involved in administrating these new entities.
Elvira Ismagilova   +3 more
semanticscholar   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

open access: yesMolecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern   +7 more
wiley   +1 more source

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