Results 51 to 60 of about 3,871 (249)

Compensatory Mitophagy via NEDD4/HIF‐1α/BNIP3 Pathway Restrains EndMT and Renal Allograft Interstitial Fibrosis Induced by TNFα

Advanced Science, EarlyView.
The role of TNFα in the process of renal allograft interstitial fibrosis is complex and multifaceted. As it can promote renal allograft interstitial fibrosis by inducing mitochondrial dysfunction and EndMT, and also mediating compensatory mitophagy through the NEDD4–HIF‐1α–BNIP3 pathway, which clears damaged mitochondria and inhibits EndMT, thereby ...
Dengyuan Feng, Qinghuan Shen, Junqi Zhang, Jiawen Liu, Zeping Gui, Zijie Wang, Qianguang Han, Shuang Fei, Hao Chen, Li Sun, Jun Tao, Zhijian Han, Xiaobing Ju, Min Gu, Jianjian Zhang, Ruoyun Tan   +15 more
wiley   +1 more source

Augmented Fibroblast Growth Factor-23 Secretion in Bone Locally Contributes to Impaired Bone Mineralization in Chronic Kidney Disease in Mice

Frontiers in Endocrinology, 2018
Chronic kidney disease-mineral and bone disorder (CKD-MBD) is a systemic disorder of mineral and bone metabolism caused by CKD. Impaired bone mineralization together with increased bony secretion of fibroblast growth factor-23 (FGF23) are hallmarks of ...
Olena Andrukhova, Christiane Schüler, Claudia Bergow, Alexandra Petric, Reinhold G. Erben   +4 more
doaj   +1 more source

Multidimensional and Multifunctional Laser‐Induced Graphene (LIG) for Point‐of‐Care and Wearable Biosensing, Theranostics, and Bioactive Interfaces Toward Personalized Healthcare and Regenerative Medicine

Advanced Science, EarlyView.
Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang, Yurou Yuan, Xiaohong Ding, Wing Cheung Mak   +3 more
wiley   +1 more source

CKD-MBD after kidney transplantation

Pediatric Nephrology, 2011
Successful kidney transplantation corrects many of the metabolic abnormalities associated with chronic kidney disease (CKD); however, skeletal and cardiovascular morbidity remain prevalent in pediatric kidney transplant recipients and current recommendations from the Kidney Disease Improving Global Outcomes (KDIGO) working group suggest that bone ...
Wesseling-Perry, Katherine, Bacchetta, Justine   +1 more
openaire   +2 more sources

COSMOS: the dialysis scenario of CKD–MBD in Europe [PDF]

Nephrology Dialysis Transplantation, 2012
Chronic kidney disease-mineral and bone disorders (CKD-MBD) are important complications of CKD5D patients that are associated with mortality.COSMOS is a multicentre, open cohort, prospective, observational 3-year study carried out in haemodialysis patients from 20 European countries during 2005-07. The present article describes the main characteristics
Luis Fernandez-Martin, Jose, Carrero, Juan Jesus, Benedik, Miha, Bos, Willem-Jan, Covic, Adrian, Ferreira, Anibal, Floege, Juergen, Goldsmith, David, Luis Gorriz, Jose, Ketteler, Markus, Kramar, Reinhard, Locatelli, Francesco, London, Gerard, Martin, Pierre-Yves, Memmos, Dimitrios, Nagy, Judit, Naves-Diaz, Manuel, Pavlovic, Drasko, Rodriguez-Garcia, Minerva, Rutkowski, Boleslaw, Teplan, Vladimir, Tielemans, Christian, Verbeelen, Dierik, Wuethrich, Rudolf P., Martinez-Camblor, Pablo, Cabezas-Rodriguez, Ivan, Emilio Sanchez-Alvarez, Jose, Cannata-Andia, Jorge B.   +27 more
openaire   +6 more sources

Miro1 Protects Against Acute Kidney Injury Through Modulating Mitochondrial Homeostasis via Interaction With Sirt6

Advanced Science, EarlyView.
Ischemia‐reperfusion reduces Sirt6 activity, thereby increasing Miro1 acetylation. Hyperacetylated Miro1 exhibits perinuclear distribution and degradation, thereby inducing mitochondrial dysfunction and promoting apoptosis in renal tubular epithelial cells. This pathway reveals a mechanistic link between Sirt6‐mediated deacetylation and Miro1 stability
Lin Wu, Qing Li, Yiyang Xu, Zitao Wang, Hua Shu, Yangfan Wu, Fang Lu, Zhimin Huang, Bo Zhang, Hongwei Liang, Changying Xing, Huijuan Mao, Yanggang Yuan   +12 more
wiley   +1 more source

Association between serum phosphate levels and anemia in non-dialysis patients with chronic kidney disease: a retrospective cross-sectional study from the Fuji City CKD Network

BMC Nephrology, 2023
Background Patients with chronic kidney disease (CKD) present high mortality and morbidity rates despite the availability of various therapies. Although CKD-mineral and bone disorder (MBD) and renal anemia are important factors in patients with CKD, only
Kazuhiko Kato, Akio Nakashima, Ichiro Ohkido, Kenji Kasai, Takashi Yokoo   +4 more
doaj   +1 more source

Gαi1/3 Are Essential for BMP2‐Induced Osteogenesis by Bridging BMP Receptors to the Gab1 Signaling Complex

Advanced Science, EarlyView.
The Gαi1/3 protein is a crucial connecting protein closely related to the signal transduction process of bone formation‐related cytokines such as BMP2. Gαi1/3 mediates downstream signaling pathways such as Smads and MAPK by binding to adaptor proteins like Gab1, thereby promoting the osteogenic effect of BMSCs.
Huajian Shan, Chaowen Bai, Yifei Zhu, Chenyang Xu, Sonngtao Li, Qize Sun, Chang She, Jinyu Bai, Cong Cao, Yitian Yang, Xiaozhong Zhou   +10 more
wiley   +1 more source

Targeting casein kinase 2 and ubiquitin-specific protease 7 to modulate RUNX2-mediated osteogenesis in chronic kidney disease

Molecular Medicine
Objective Chronic Kidney Disease (CKD) frequently leads to Mineral Bone Disorder (MBD), which significantly affects patient quality of life due to bone fragility and metabolic disturbances.
Haifeng Lan, Xiao-Jun Yu, Guangsheng Ling, Yuwei Zeng, Yixi Yang, Meiyang He, Yixiao Yu, Ming Shao   +7 more
doaj   +1 more source

Markers of Mineral Metabolism in Children With CKD Stages 2 to 5D

Kidney International Reports
Introduction: Changes in age- and sex-related markers for chronic kidney disease (CKD)–mineral and bone disorder (MBD) (CKD-MBD) across CKD stages 2 to 5D have not yet been studied in children. Methods: In this cross-sectional study, we investigated age,
Anna Tschirner, Hannah Weber, Katharina Schermuly, Ineke Böckmann, Marko Pekic, Nele Kanzelmeyer, Jens Drube, Dieter Haffner, Maren Leifheit-Nestler   +8 more
doaj   +1 more source