Results 61 to 70 of about 3,871 (249)

Calcium as a cardiovascular toxin in CKD-MBD [PDF]

Bone, 2017
Disordered calcium balance and homeostasis are common in patients with chronic kidney disease. Such alterations are commonly associated with abnormal bone remodeling, directly and indirectly. Similarly, positive calcium balance may also be a factor in the pathogenesis of extra skeletal soft tissue and arterial calcification. Calcium may directly affect
openaire   +2 more sources

Renal Tubular Epithelial CRLF1 Interacts With ITGB1 to Accelerate Fibrosis During the Transition From AKI to CKD

Advanced Science, EarlyView.
During renal fibrosis, SMAD3 acts as a transcription factor for CRLF1, promoting its expression and secretion. CRLF1 then binds to ITGB1 via an autocrine mechanism, activating the PI3K‐AKT signaling pathway to mediate renal fibrosis. This accelerates the progression from AKI to CKD, highlighting the therapeutic potential of targeting CRLF1 for ...
Chunjie Wang, Yan Zhang, Fang Bai, Shankui Qian, Feng Feng, Fangyi Lu, Jiahui Fan, Kuipeng Yu, Xiangdong Yang   +8 more
wiley   +1 more source

SPARC Drives Podocyte Mitochondrial Damage and Ferroptosis in Diabetic Kidney Disease Following Klotho Deficiency

Advanced Science, EarlyView.
Klotho deficiency promotes podocyte mitochondrial dysfunction and ferroptosis through activation of the PKCα/CUX1/SPARC/TGFβ‐RII axis. SPARC emerges as a key mediator linking Klotho loss to podocyte injury in DKD and other kidney injury models, suggesting broader implications for CKD progression.
Qing Yang, Huimin Jiang, Chenyang Xiong, Xindi Zhou, Qinqin Tan, Han Xiao, Lan Qiu, Chun Gan, Yaxi Chen, Haiping Yang, Wei Jiang, Qiu Li   +11 more
wiley   +1 more source

CKD-MBD - A [PDF]

Nephrology Dialysis Transplantation, 2013
K. Stevens, E. Beattie, C. Delles, A. Jardine, K. Neumann, L. Fang, E. Ritz, M.-L. Gross-Weissmann, G. Kokeny, C. Nakano, T. Hamano, N. Fujii, I. Matsui, S. Mikami, Y. Obi, A. Shimomura, H. Rakugi, Y. Tsubakihara, Y. Isaka, N. Torremade, M. V. Arcidiacono, P. Valcheva, M. Bozic, E. Fernandez, J. M. Valdivielso, S. Rotondi, M. Pasquali, C. Conte, C. Leonangeli, M. L. Muci, G. Pirro, L. Tartaglione, S. Mazzaferro, U. Janssen, S. Naderi, M. Hennies, T. Kruger, V. Brandenburg   +37 more
openaire   +3 more sources

Klotho‐Derived Peptide 1 Protects against Acute Kidney Injury by Directly Targeting Mitochondrial ATAD3A

Advanced Science, EarlyView.
This study uncovers that KP1, a Klotho‐derived peptide, protects the kidney against acute kidney injury, a clinical syndrome with high morbidity and mortality. KP1 enters tubular epithelial cells via endocytosis, directly interacts with the mitochondrial ATAD3A/HIGD2A complex, thereby preventing cytochrome c release, and caspases activation, and ...
Xiaoyao Zhang, Shihui Lin, Tianyu Wu, Zhixin Zhang, Hong Zhou, Xue Hong, Youhua Liu   +6 more
wiley   +1 more source

D4F‐Functionalized Ceria Nanozyme‐CasRx Platform Suppresses STING and Reprograms the Renal Immune Niche in Acute Kidney Injury

Advanced Science, EarlyView.
D4F‐functionalized ceria nanozyme–CasRx nanoparticles preferentially target renal macrophages through SR‐B1‐mediated uptake in ischemia–reperfusion injury. Ceria scavenges excessive ROS, while CasRx silences STING signaling, shifting macrophages toward a less inflammatory, pro‐resolving state and increasing the proportion of regulatory T cells.
Weibo Chen, Ming Li, Xuesheng Wang, Jiajia Sun, Ziyuan Zhang, Yongfeng Gong, Benkang Shi, Nengwang Yu, Yunuo Mao, Shengtian Zhao, Xiulin Zhang, Liqiang Guo   +11 more
wiley   +1 more source

Chronic Kidney Disease–Mineral and Bone Disorder (CKD-MBD): Current Perspectives

International Journal of Nephrology and Renovascular Disease, 2019
Bala Waziri,1,2 Raquel Duarte,1 Saraladevi Naicker1 1Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; 2Department of Medicine, Ibrahim Badamasi Babangida Specialist Hospital, Minna,
Waziri B, Duarte R, Naicker S
doaj  

Evaluation of CaSR rs1801725 and circulating miRNA-21-5p and miRNA-124-3p expression in chronic kidney disease-mineral and bone disorder patients

Egyptian Journal of Medical Human Genetics
Background Chronic kidney disease-mineral and bone disorder (CKD-MBD) has been a prominent consequence of end-stage renal disease (ESRD), increasing cardiovascular risk and skeletal fragility. Emerging research shows that genetic and epigenetic variables
Enas Ahmed Osman, Samia Hassan El-shishtawy, Farida M. Khanany   +2 more
doaj   +1 more source

Cardiovascular Risk Factors and Chronic Kidney Disease—FGF23: A Key Molecule in the Cardiovascular Disease

International Journal of Hypertension, 2014
Patients with chronic kidney disease (CKD) are at increased risk of mortality, mainly from cardiovascular disease. Moreover, abnormal mineral and bone metabolism, the so-called CKD-mineral and bone disorder (MBD), occurs from early stages of CKD.
Rika Jimbo, Tatsuo Shimosawa
doaj   +1 more source

Vitamin D and kidney disease

Bone Reports, 2018
Calcium and phosphorus are essential minerals required for many critical biologic functions including cell signaling, energy metabolism, skeletal growth and integrity. Calcium and phosphate homeostasis are maintained primarily by regulation of epithelial
Lisa Keung, Farzana Perwad
doaj   +1 more source