Results 81 to 90 of about 303,943 (292)

Metabolic profiling of human plasma and urine in chronic kidney disease by hydrophilic interaction liquid chromatography coupled with time-of-flight mass spectrometry : a pilot study [PDF]

, 2017
A typical characteristic of chronic kidney disease (CKD) is the progressive loss in renal function over a period of months or years with the concomitant accumulation of uremic retention solutes in the body.
Boelaert, Jente, Glorieux, Griet, Lynen, Frederic, Neirynck, Nathalie, Schepers, Eva, Vanholder, Raymond   +5 more
core   +1 more source

Insulin Resistance in CKD [PDF]

Clinical Journal of the American Society of Nephrology, 2014
Insulin resistance is typically defined as decreased biologic action of insulin at its target organs ( e.g., liver, skeletal muscles) for any given blood concentration of insulin. Clinically it usually presents with hyperinsulinemia, glucose intolerance, hyperglycemia, and dyslipidemia ...
Sarah, Leyking, Danilo, Fliser
openaire   +2 more sources

Tubule‐Derived IFN‐α Promotes GSDMD‐Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation

Advanced Science, EarlyView.
Mao and colleagues uncover a STAT2/IRF9‐dependent signaling axis through which tubular epithelial cell (TEC)‐derived IFN‐α induces gasdermin D (GSDMD)‐mediated pyroptosis in macrophages. This TEC‐macrophage feedback loop amplifies renal inflammation and fibrosis, providing mechanistic insight into the progression of chronic kidney disease and revealing
Yiping Xu, Yating Wang, Siming Jiang, Yi Li, Guanglan Li, Yuchu Liu, Siyuan Li, Yiming Zhou, Qinghua Liu, Yi Zhou, Wei Chen, Hongyu Li, Haiping Mao   +12 more
wiley   +1 more source

Adapting a Self-Management Tool (My Kidneys My Health) to Meet the Needs of Diverse Canadian Populations: Program Report

Canadian Journal of Kidney Health and Disease
Purpose of Program: Our team co-developed My Kidneys My Health , an online platform designed with patients with non-dialysis-dependent chronic kidney disease and care partners to provide tailored education and self-management support. While My Kidneys My
Maoliosa Donald, Sabrina Jassemi, Shannan Love, Gillian Crysdale, Dwight Sparkes, Maria Delgado, Laurinda Ferreira, Betty Pearson, Nancy Verdin, Kaitlin Ahrenholz, Violet March, Maureena Loth, Sarah Gil, Heather Beanlands, Aminu Bello, Sandra Dumanski, Janine Farragher, Lori Harwood, Allison Jaure, Joanne Kappel, Ellen Novak, Sharon Straus, Catherine Turner, Clare McKeaveney, Brenda R. Hemmelgarn, Meghan J. Elliott   +25 more
doaj   +1 more source

Exploring metabolic dysfunction in chronic kidney disease [PDF]

, 2012
Impaired kidney function and chronic kidney disease (CKD) leading to kidney failure and end-stage renal disease (ESRD) is a serious medical condition associated with increased morbidity, mortality, and in particular cardiovascular disease (CVD) risk ...
Slee, Adrian D.
core   +2 more sources

Cholesterol Metabolism in CKD [PDF]

American Journal of Kidney Diseases, 2015
Patients with chronic kidney disease (CKD) have a substantial risk of developing coronary artery disease. Traditional cardiovascular disease (CVD) risk factors such as hypertension and hyperlipidemia do not adequately explain the high prevalence of CVD in CKD.
Allison B, Reiss, Iryna, Voloshyna, Joshua, De Leon, Nobuyuki, Miyawaki, Joseph, Mattana   +4 more
openaire   +2 more sources

A Novel 10‐Protein Score for Liver Fat Content Predicts Cardiovascular‐Kidney‐Metabolic Disease Risk

Advanced Science, EarlyView.
A novel 10‐protein plasma score precisely quantifies liver fat, outperforming the fatty liver index. It robustly predicts the risk of numerous cardiovascular‐kidney‐metabolic diseases and integrates with genetic data for precision prevention, offering a practical alternative to magnetic resonance imaging (MRI). Abstract Liver fat content (LFC) is a key
Xiaoqin Gan, Yuanxiu Wei, Yiting Wu, Xinyue Su, Gangling Wang, Sisi Yang, Ziliang Ye, Yanjun Zhang, Hao Xiang, Yu Huang, Yiwei Zhang, Yuanyuan Zhang, Xianhui Qin   +12 more
wiley   +1 more source

Characteristics of Xerosis, Pruritus, and Pallor in Stage 5 Chronic Kidney Disease Patients Undergoing Hemodialysis at Dr. Hasan Sadikin General Hospital, Bandung

Clinical, Cosmetic and Investigational Dermatology, 2023
Reiva Farah Dwiyana,1,* Laila Tsaqilah,1,* Lilik Sukesi,2,* Setiawan,3 Erda Avriyanti,1 Kamelia Utami Suhada,1 Nazya Irene Zahira4 1Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran-Dr.
Dwiyana RF, Tsaqilah L, Sukesi L, Setiawan, Avriyanti E, Suhada KU, Zahira NI   +6 more
doaj  

Mechanisms of Aristolochic Acid Resistance in Specialist Butterflies and Evolutionary Insights for Potential Protective Pathways

Advanced Science, EarlyView.
The study provides an extreme example of insect adaptation to highly toxic defenses of host plants, and investigates the complex strategies to resist carcinogenic aristolochic acids, including physical isolation, metabolic detoxification, and DNA repair.
Yang Luan, Yubo Zhang, Jingjing Li, Jianqing Zhu, Yuyang Lei, Yushi Hu, Zhenqiang Xin, Tianpei Xie, Jiang Zheng, Yuanyuan Lin, Jingjing Shen, Yiyi Cao, Xinyue You, Jing Xi, Jiaying Wu, Weiying Liu, Xinyu Zhang, Yuanting Zheng, David J. Lohman, Leming Shi, Wei Zhang   +20 more
wiley   +1 more source

Effectiveness of Pre‐Transplant Dual GLP‐1 Receptor Agonist and SGLT2 Inhibitor Therapy on All‐Cause Mortality in Organ Transplantation Candidates with Obesity and Type 2 Diabetes: a Target‐Trial Emulation

Advanced Science, EarlyView.
This target trial emulation in solid organ transplant candidates with obesity and type 2 diabetes evaluates whether pre‐transplant dual therapy with GLP‐1 receptor agonists plus SGLT2 inhibitors is associated with post‐transplant mortality and kidney graft outcomes compared with monotherapy or usual care, using multinational electronic health records ...
Yu‐Nan Huang, Min‐Yu Tsou, Pin‐Hung Li, Jo‐Ching Chen, Yen‐Liang Liu, Gideon Meyerowitz‐Katz, Tsung‐Hsun Tsai, Pen‐Hua Su   +7 more
wiley   +1 more source