Results 101 to 110 of about 258,864 (309)

SPARC Drives Podocyte Mitochondrial Damage and Ferroptosis in Diabetic Kidney Disease Following Klotho Deficiency

Advanced Science, EarlyView.
Klotho deficiency promotes podocyte mitochondrial dysfunction and ferroptosis through activation of the PKCα/CUX1/SPARC/TGFβ‐RII axis. SPARC emerges as a key mediator linking Klotho loss to podocyte injury in DKD and other kidney injury models, suggesting broader implications for CKD progression.
Qing Yang, Huimin Jiang, Chenyang Xiong, Xindi Zhou, Qinqin Tan, Han Xiao, Lan Qiu, Chun Gan, Yaxi Chen, Haiping Yang, Wei Jiang, Qiu Li   +11 more
wiley   +1 more source

Frag-lose Einsamkeit? Zum Start des CKD-Querschnittsprojektes „Einsamkeit im Alter“ [PDF]

, 2023
Möde, Erwin
core   +1 more source

CKD-5 Predialysis Group-Differences in illness perceptions between participants who choose hospital HD vs other modalities (logistic regression analysis).

, 2016
CKD-5 Predialysis Group-Differences in illness perceptions between participants who choose hospital HD vs other modalities (logistic regression analysis).
Anuradha Jayanti (741138), Philip Foden (741139), Sandip Mitra (741141), Alison Wearden (649276)   +3 more
core   +1 more source

Klotho‐Derived Peptide 1 Protects against Acute Kidney Injury by Directly Targeting Mitochondrial ATAD3A

Advanced Science, EarlyView.
This study uncovers that KP1, a Klotho‐derived peptide, protects the kidney against acute kidney injury, a clinical syndrome with high morbidity and mortality. KP1 enters tubular epithelial cells via endocytosis, directly interacts with the mitochondrial ATAD3A/HIGD2A complex, thereby preventing cytochrome c release, and caspases activation, and ...
Xiaoyao Zhang, Shihui Lin, Tianyu Wu, Zhixin Zhang, Hong Zhou, Xue Hong, Youhua Liu   +6 more
wiley   +1 more source

Diagnosis of oral disorders in patients with chronic kidney disease

Клинический разбор в общей медицине, 2021
Chronic kidney disease results in severe disruptions to metabolic pathways, which contributes to tissue and organ damage, including damage to oral mucosa.
Irina K. Lutskaya
doaj  

Chronic Kidney Disease – Where Next? : Predicting Outcomes And Planning Care Pathways [PDF]

, 2014
Peer ...
Marks, Angharad, Black, Corri, Fluck, Nicholas, Angharad Marks, Nicholas Fluck, Corri Black   +5 more
core   +2 more sources

How to improve drug dosing for patients with renal impairment in primary care - a cluster-randomized controlled trial [PDF]

, 2012
Background: Patients with chronic kidney disease (CKD) are at increased risk for inappropriate or potentially harmful prescribing. The aim of this study was to examine whether a multifaceted intervention including the use of a software programme for the ...
Gerlach, Ferdinand M., Beyer, Martin, Justine Rochon, Kristina Saal, Haefeli, Walter E., Ferdinand M Gerlach, Erler, Antje, Thomas Rath, Walter E Haefeli, Petersen, Juliana, Rochon, Justine, Rath, Thomas, Saal, Kristina, Martin Beyer, Antje Erler, Juliana J Petersen   +15 more
core   +2 more sources

D4F‐Functionalized Ceria Nanozyme‐CasRx Platform Suppresses STING and Reprograms the Renal Immune Niche in Acute Kidney Injury

Advanced Science, EarlyView.
D4F‐functionalized ceria nanozyme–CasRx nanoparticles preferentially target renal macrophages through SR‐B1‐mediated uptake in ischemia–reperfusion injury. Ceria scavenges excessive ROS, while CasRx silences STING signaling, shifting macrophages toward a less inflammatory, pro‐resolving state and increasing the proportion of regulatory T cells.
Weibo Chen, Ming Li, Xuesheng Wang, Jiajia Sun, Ziyuan Zhang, Yongfeng Gong, Benkang Shi, Nengwang Yu, Yunuo Mao, Shengtian Zhao, Xiulin Zhang, Liqiang Guo   +11 more
wiley   +1 more source

The GPX3‐VCAM1 Axis Gates Pro‐Fibrotic Tubule Cell Fate in Hyperuricemic Nephropathy

Advanced Science, EarlyView.
Hyperuricemia induces NLRP3 inflammasome signaling activation and downregulation of GPX3 in proximal tubular epithelial cells, leading to oxidative stress–driven VCAM1 upregulation, emergence of pro‐fibrotic proximal tubule cells, macrophage recruitment, and renal fibrosis.
Yunfei Qi, Qiang Zhao, Yue Lve, Yaming Yuan, Tingting Zhou, Yue Yuan, Dexi Wu, Yifan Tang, Yan Liu, Zhigang Li, Chunping Jiang, Qiurong Ding   +11 more
wiley   +1 more source

POS-828 WABISHKI BIZHIKO SKAANJ: A LEARNING PATHWAY TO FOSTER BETTER INDIGENOUS CULTURAL COMPETENCE WITHIN CANADIAN KIDNEY RESEARCH

Kidney International Reports, 2021
C. Settee, H. Robinson-Settee, A. Desjarlais, C. Turner, M. King   +4 more
doaj   +1 more source