Results 111 to 120 of about 343,907 (366)

ACLY‐Driven Metabolic Reprogramming Promotes Histone Acetylation and Inflammation‐Associated Fibrosis in Chronic Kidney Disease

Advanced Science, EarlyView.
This study reveals a citrate–ACLY–H3K27ac metabolic–epigenetic axis driving inflammatory gene activation and kidney fibrosis, highlighting ACLY inhibition as a potential therapeutic strategy for chronic kidney disease (CKD). ABSTRACT The mechanisms by which metabolic stress drives epigenetic dysregulation and fibrosis in chronic kidney disease (CKD ...
Chunxiu Du, Dhanunjay Mukhi, Lingzhi Li, Chenyu Li, Siyu Pan, Bernhard Dumoulin, Eunji Ha, Lakshmi P Kolligundla, Yanjuan Hou, Jonathan Levinsohn, Chaelin Kang, Konstantin Adrian Klötzer, Junnan Wu, Samer Mohandes, Kathryn E Wellen, Katalin Susztak   +15 more
wiley   +1 more source

CKD-5 Predialysis Group-Differences in illness perceptions between participants who choose hospital HD vs other modalities (logistic regression analysis).

, 2016
CKD-5 Predialysis Group-Differences in illness perceptions between participants who choose hospital HD vs other modalities (logistic regression analysis).
Anuradha Jayanti (741138), Philip Foden (741139), Sandip Mitra (741141), Alison Wearden (649276)   +3 more
core   +1 more source

Targeting Endogenous Lipophagy: A Novel Strategy to Enhance MSC Osteogenesis and Mineralization for Senile Osteoporosis Therapy

Advanced Science, EarlyView.
Schematic representation of the role of lipophagy in bone mesenchymal stem cells(MSCs). In healthy MSCs, functional lipophagy efficiently degrades lipid droplets to support oxidative phosphorylation and cellular energy production, thereby facilitating osteogenic differentiation and matrix mineralization.
Chaoqiang Chen, Zhidong Liu, Yanhang Sun, Xiaojun Xu, Zhexiao Lan, Junhao Zhao, Peitao Xu, Guiwen Ye, Jinteng Li   +8 more
wiley   +1 more source

T Cell‐Independent Role of PD‐L1 in Kidney Repair: Mitigation of Tubular DNA Damage via PD‐L1/BRCA1 Interaction Following AKI

Advanced Science, EarlyView.
PD‐L1 is primarily expressed in renal tubules and upregulated in both murine models of AKI and renal biopsy samples from patients with AKI. PD‐L1 can promote adaptive TECs repair through interacting with BRCA1, independent of its canonical immunomodulatory function of T cells, and PD‐L1 supplementation may represent a promising therapeutic strategy for
Wei Jiang, Tao‐Tao Tang, Wei‐Jie Ni, Jin‐Xuan Wei, Liang‐Yun‐Zi Jiang, Qing Yin, Yi‐Lin Zhang, Zuo‐Lin Li, Yi Wen, Xin‐Lu Wang, Jun‐Yuan Shen, Xiao‐Jun Ouyang, Ming‐Zhu Zheng, Jian Xu, Xiaofei An, Lin‐Li Lv, Bi‐Cheng Liu, Bin Wang   +17 more
wiley   +1 more source

Cardiovascular risk in chronic kidney disease (CKD): the CKD-mineral bone disorder (CKD-MBD) [PDF]

Pediatric Nephrology, 2009
Recent advances in our understanding of the excess mortality of chronic kidney disease (CKD) due to cardiovascular complications, obtained through observational studies, demonstrate that vascular calcification and hyperphosphatemia are major cardiovascular risk factors.
Keith A, Hruska, Eric T, Choi, Imran, Memon, T Keefe, Davis, Suresh, Mathew   +4 more
openaire   +2 more sources

Exposure-CKD-clumped selected SNP.

BackgroundChronic Kidney Disease (CKD) represents a global health challenge, with its etiology and underlying mechanisms yet to be fully elucidated.
Yongzheng Hu (17965611), Wei Jiang (14986)   +1 more
core   +1 more source

A collaborative, individual-level analysis compared longitudinal outcomes across the International Network of Chronic Kidney Disease (iNETCKD) cohorts.

, 2019
Rates of chronic kidney disease (CKD) progression, end stage kidney disease (ESKD), all-cause mortality, and cardiovascular (CVD) events among individuals with CKD vary widely across countries.
Djurdjev, Ognjenka, Wendy Hoy, Oh, K-H, Hoy, Wendy, Kook-Hwan Oh, Curie Ahn, Zaimin Wang, Go, Alan, Feldman, Harold I., Oh, Kook-Hwan, Cockwell, P, Sola, Laura, Wang, Zaimin, Lawrence Appel, iNET-CKD Collaborators, Pablo G. Rios, Naohiko Fujii, Mila Tang, Orlandi, Paula F., Anthony Fenton, Vivek Kumar, Vivekanand Jha, Ahn, Curie, Wendy E. Hoy, Fukagawa, Masafumi, Orlandi, Paula F, Levin, A, Jianzhen Zhang, Jha, Vivekanand, Jing Huang, Adeera Levin, Hoy, Wendy E., Huang, Jing, Paula F. Orlandi, Liliana Gadola, Alan Go, Takayuki Hamano, Appel, Lawrence, Han, Seung Hyeok, Hoy, W, Orlandi, PF, Fenton, Anthony, Lisa Nessel, Tang, Mila, Seung Hyeok Han, Helen G. Healy, Dong Wan Chae, Rios, Pablo G., Zhang, Jianzhen, Laura Sola, Ashok Kumar Yadav, Feldman, HI, Paul Cockwell, Harold I. Feldman, Feldman, Harold I, Sola, L, Levin, Adeera, Masafumi Fukagawa, Chae, Dong Wan, Nessel, Lisa, Fukagawa, M, Cockwell, Paul, Huang, J, Takahiro Imaizumi, Healy, Helen G., Ognjenka Djurdjev   +65 more
core   +1 more source

Caveolin‐1 Stabilizes SERCA2 to Counteract Acute Kidney Injury via Suppression of Ca2+‐Dependent Endoplasmic Reticulum Stress in Distal Tubules

Advanced Science, EarlyView.
In AKI, initial kidney injury upregulates the expression of Cav‐1, which subsequently binds to and stabilizes SERCA2 via its scaffolding domain and through deubiquitination, thereby regulating Ca2+ homeostasis and ER stress. Conversely, Cav‐1 deficiency accelerates SERCA2 degradation, triggering Ca2+ overload and ER stress, and ultimately exacerbating ...
Yan Zhang, Xin He, Hao Huang, Rong Lu, Xin Lv, Shenglan Li, Sijue Zou, Jiawei Cheng, Yiwei Xiong, Zhenghao Deng, Qiongjing Yuan, Yanyun Xie, Ling Huang, Jiaxi Pu, Shao Liu, Qianbin Li, Jie Meng, Huixiang Yang, Lijian Tao, Zhangzhe Peng   +19 more
wiley   +1 more source

Combining Spatial Multi‐Omics Data to Decipher Spatial Domains and Elucidate Cell Heterogeneity Based on Self‐Supervised Graph Learning

Advanced Science, EarlyView.
A self‐supervised multi‐view graph fusion framework integrates spatial multi‐omics, excelling in domain identification and denoising. It reconstructs spatial pseudo‐expression, jointly analyzes multi‐omics data, infers RNA velocity, predicts spatial omics features from single‐cell multi‐omics, and detects spatially dark genes and transcription factors,
Yuejing Lu, Rui Qiao, Ying Li, Junhong Li, Nuoya Yue, Jing Ge, Jiao Wang, Luonan Chen, Peiluan Li   +8 more
wiley   +1 more source

POS-469 ENHANCING PATIENT CARE BY PARTNERING WITH PATIENTS IN KIDNEY HEALTH RESEARCH

Kidney International Reports, 2021
L. Getchell, M. Beaucage, D. Hillier, A. MacPhee, H. Vorster, G. Pollock   +5 more
doaj   +1 more source