Results 51 to 60 of about 2,447 (177)

Improvement of Kidney Function Following Unilateral Nephrectomy in a Patient With Cardiovascular-Kidney-Metabolic (CKM) Syndrome. [PDF]

Cureus
Cardiovascular-kidney-metabolic (CKM) syndrome is a significant contributor to the progressive decline in renal function, often leading to advanced chronic kidney disease. We report a 55-year-old man with a history of obesity, diabetes, and hypertension who was diagnosed with renal cell carcinoma (RCC) and underwent unilateral nephrectomy for his ...
Asopa M, Kamgar M, Wilson J, Emami S, Shuch B, Nobakht N.   +5 more
europepmc   +3 more sources

Cardiovascular‐Kidney‐Metabolic Syndrome: Conceptualising an Approach to Health Economic Modelling

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Cardiovascular‐kidney‐metabolic (CKM) syndrome has developed into a global public health crisis. Although integrated care is increasingly used to treat patients with CKM, current health economic models fail to capture the value of considering the CKM syndrome as a unified condition.
Volker Foos, Jieling Chen, Phil McEwan, Marc Evans, Pardeep S. Jhund, Paul R. Kalra, Hongtu Zhu, David C. Wheeler, Geraint Roberts, Martin R. Cowie, Andrew H. Briggs   +10 more
wiley   +1 more source

Sodium–glucose cotransporter 2 inhibitors for hypertension in cardiovascular–kidney–metabolic syndrome

Experimental Physiology, EarlyView.
Abstract The antihypertensive mechanism of sodium–glucose cotransporter 2 (SGLT2) inhibitors has been traditionally attributed to osmotic diuresis. However, emerging evidence reveals multifaceted mechanisms beyond diuresis, including regulation of the renin–angiotensin–aldosterone system, sympathetic nervous system suppression, ion homeostasis ...
Chunxiang Xu, Xingyu Qiu, Nan Xu, Gensheng Zhang, Enyin Lai, Liang Zhao   +5 more
wiley   +1 more source

Association between systemic inflammation response index and advanced stages in U.S. cardiovascular-kidney-metabolic syndrome patients: a cross-sectional study using NHANES 2015–2020 data

BMC Cardiovascular Disorders
Background The American Heart Association introduced cardiovascular-kidney-metabolic (CKM) syndrome, a highly prevalent multistage comorbidity in the U.S.
Jing Zhang, Dingyuan Tu
doaj   +1 more source

Lifestyle modification in atrial fibrillation: Mechanisms, phenotypes and ablation outcomes

Experimental Physiology, EarlyView.
Abstract Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia and is associated with significant morbidity, mortality and healthcare utilization. Catheter ablation is increasingly used as a rhythm‐control intervention for patients with symptomatic paroxysmal and persistent AF, yet recurrence rates remain suboptimal.
Konstantinos Grigoriou, Paschalis Karakasis, Panagiotis Theofilis, Konstantinos Pamporis, Panayotis K. Vlachakis, Anastasios Apostolos, Nikolaos Ktenopoulos, Barbara Fyntanidou, Efstratios Karagiannidis, Dimitrios Patoulias, Antonios P Antoniadis, Nikolaos Fragakis   +11 more
wiley   +1 more source

Using the American heart association's new 'cardiovascular-kidney-metabolic syndrome' metrics to assess life expectancy in us adults: A life table analysis

American Journal of Preventive Cardiology
Background: Cardiac, kidney, and metabolic diseases are associated with a short life expectancy. However, the potential impact of the cardiovascular-kidney-metabolic (CKM) syndrome, recently introduced by the American Heart Association (AHA), on life ...
Zhendong Cheng, Wenqing Xu, Jianping Luo, Xianghui Zeng, Qingfeng Zeng, Gang Cao, Guosheng Liu, Chunqing Xiao   +7 more
doaj   +1 more source

Hyperaldosteronism in the Pathophysiology and Management of Cardiovascular‐Kidney‐Metabolic Syndrome

Diabetes, Obesity and Metabolism, Volume 28, Issue 7, Page 5463-5475, July 2026.
ABSTRACT Cardiovascular‐kidney‐metabolic (CKM) syndrome is defined by the pathologic interconnections between obesity, diabetes, chronic kidney disease and cardiovascular disease. An important and underrecognized pathophysiologic factor underlying CKM syndrome is obesity‐induced aldosterone excess.
Evan Zeitler, Klara R. Klein, Ildiko Lingvay, Anthony Pick, Liana K. Billings   +4 more
wiley   +1 more source

The association between shift work, occupational physical activity and cardiovascular-kidney-metabolic syndrome: a cohort study in China

Frontiers in Public Health
BackgroundThe relationship between shift work, occupational physical activity (OPA), and CKM syndrome remains unclear. The present study aimed to investigate the independent and joint associations of these two factors with CKM syndrome.MethodsThis study ...
Xiangran Zhang, Wanyu Wang, Haixia Lu, Changxue Huang, Yuxin Jin, Manli Xiang, Cainan Sun, Di Li, Li Chen, Xiujuan Wu, Hongzhan Sun, Yulong Lian, Dajun Zhang   +12 more
doaj   +1 more source

Effects of Vicadrostat/Empagliflozin in People With Chronic Kidney Disease: Metabolic Subgroup Analyses

Diabetes, Obesity and Metabolism, Volume 28, Issue 7, Page 6324-6333, July 2026.
ABSTRACT Aims In a phase 2 trial, the efficacy and safety of the highly selective aldosterone synthase inhibitor vicadrostat, alone or with empagliflozin, were investigated in people with chronic kidney disease (CKD) with or without type 2 diabetes (T2D). Materials and Methods Adults (n = 586) with CKD (estimated glomerular filtration rate [eGFR] 30 to
David Z. I. Cherney, Peter Rossing, Maria Eugenia Canziani, Maria Luiza Caramori, Ricardo Correa‐Rotter, Lisa Cronin, Christian Hugo, Bo Ji, Juliane Meyerhoff, Masaomi Nangaku, Arnold Silva, Dorothea Urbach, Shimoli V. Shah, Dick de Zeeuw, Katherine R. Tuttle   +14 more
wiley   +1 more source

Association of neutrophil/high-density lipoprotein cholesterol ratio with the cardiovascular-kidney-metabolic syndrome and its cardiovascular mortality

Frontiers in Nutrition
BackgroundCardiovascular-kidney-metabolic (CKM) syndrome is a novel multi-system disease defined by the American Heart Association (AHA). This study aims to investigate the associations between the neutrophil/high-density lipoprotein cholesterol ratio ...
Yaying Xu
doaj   +1 more source